Our results provide further robust data supporting an association between two gene regions (PITX2 and ZFHX3) and cardioembolic stroke, and a further two (HDAC9 and 9p21) with large-vessel stroke although the 9p21 locus did not reach genome-wide significance. In all cases, these associations were present in the dataset as a whole, and also when those samples used in the original discovery cohorts that identified associations with ischaemic stroke were excluded.
