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Chunk #73 — Online Methods — eQTL analysis

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A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.
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For conditional analysis, we performed analysis for SPI1 (probe: ILMN_1696463) against all SNPs within ±2Mb from the closest transcript end, by including the following SNPs effective allele copy numbers as covariates in the linear regression model, one at a time: rs1057233, rs10838698, rs7928163, rs10838699, rs10838725, rs1377416. Significance was again assessed with a two-sided Wald test on the OLS estimator of the coefficient β.