it is possible additional regions would have been identified in a whole brain analyses. Also, our focus on expanding our understanding of mechanisms contributing to the lower feelings of intoxication in low LR subjects, along with restrictions in both finances and testing time, resulted in the absence of more biologically-based hormone and EEG measures. While subjects were blind to the alcohol versus placebo fMRI beverage, it is possible participants could tell the difference between the two conditions. Future work will evaluate whether such imaging characteristics themselves predict future alcohol problems, if the fMRI results add significantly to the LR measures in predicting outcomes, and if they might help identify young subjects early in their drinking careers who might be more amenable to earlier education and prevention efforts [57].
