There are several limitations in our research protocol. The subjects were all university students, predominantly Caucasian, and demonstrated no current substance use disorder or major psychiatric condition. The evaluation of emotional faces was carried out with only a single protocol, the Hariri task, and it is not clear whether similar results would be observed with alternative paradigms. The alcohol challenge involved a modest ethanol dose (peak BAC ~.06 mg/dl), and it would be interesting to determine the fMRI correlates of the LR group differential if higher alcohol doses had been administered. In addition, the alcohol was given as an oral beverage, and did not include approaches such as the intravenous alcohol clamp that might generate additional interesting data [56]. Furthermore, in order to diminish spurious findings, we limited the analyses to brain regions with known effects for this task, and it is possible additional regions would have been identified in a whole brain analyses. Also, our focus on expanding our understanding of mechanisms contributing to the lower feelings of intoxication in low LR subjects, along with restrictions in both finances
