risk score in the population (top 5.6% vs bottom 2.9%) is of clinical relevance, as it represents a shift of approximately 25 centile points in the distribution of FG. Prospective evidence has shown that a difference of this magnitude in FG is associated with a relative risk of 1.54–1.73 for future T2D, accounting for other risk factors28. The impact of individual SNPs on FG in the combined discovery and replication samples is shown in Supplementary Figure 3a–p.
