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Chunk #11 — RESULTS — Effect size estimates for genome-wide significant loci

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
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We also analyzed data from 1,602 white European children aged 5.9–17.2 from two studies. Though directionally consistent with observations in adults, some effect size estimates were of smaller magnitude (data not shown). As in adults, the largest effect sizes were observed for risk alleles in GCK (beta=0.085; P=1.2×10−5; N=1,602), G6PC2 (beta=0.062; P=1.9×10−4; N=1,582) and MTNR1B (beta=0.033; P=0.058; N=1,309).