We sought to investigate all 17 loci associated with FG/HOMA-B or FI/HOMA-IR at genome-wide significance for their effects on other continuous glycemic traits. While most of the 16 loci associated with FG are also strongly associated with HOMA-B (Tables 1 and 2), the associations between FG loci and FI were at best weak; GCKR is the only locus reaching genome-wide significant associations for both FG/HOMA-B and FI/HOMA-IR, with the glucose-raising C allele being associated with increased FI (global P=3.6×10−20) and HOMA-IR (global P=3.0×10−24). These patterns are consistent with the gross trait correlations obtained in Framingham for FG and HOMA-B (r=−0.43) and for FG and FI (r=0.25).
