Analysis of group data was based on contrasts to specifically test the principle a priori questions of the study: Lean versus Obese (obesity effect) and Tesaglitazar versus Obese (treatment effect). Analysis of Study 3 was based on detection of the above between group difference in the basal state and the responses to insulin (ClampL-Basal). The latter was interpreted as a measure of metabolic flexibility. Statistical significance of the contrasts were evaluated on the basis of F-tests using the program SPSS (SPSS Inc., Chicago, IL). Results are reported as means ± SE. P < 0.05 was considered statistically significant.
