Three groups of age matched animals were studied: vehicle treated lean (Lean) and obese Zucker (Obese) controls and obese Zuckers treated with tesaglitazar, 3 μmol/kg/day for 3 weeks (Tesaglitazar). During the treatment period body weight gain was greater in Obese compared to Lean, 4.5 ± 0.3 versus 2.3 ± 0.1 g/day, respectively; P < 0.001 and was further increased in Tesaglitazar to 8.3 ± 0.8 g/day (P < 0.01 versus Obese). Following the 3-week treatment period whole body glucose turnover was studied under basal fasting and ClampL conditions of physiological hyperinsulinemia (see Section 2). Body weights at the time of study as well as steady state glucose levels and GIRs are summarized in Table 2. This data confirms a large tesaglitazar induced increase in whole body insulin action consistent with earlier work [16].
