MDD subjects showed statistically significantly greater connection strength CE (higher overall median coherence across all edges) than controls in each of the four frequency bands, but most notably in the beta band (Kruskal Wallis p = 0.000035) (Figure 2). The topography of individual connections (edges) showing significantly greater strength CE in MDD subjects is displayed by frequency band in Figures 3A–D. In the delta and theta bands, relatively few highly significant differences in connection strength were found after applying Bonferroni correction. The most significant differences in CE in the delta band (17 edges) and theta band (42 edges) were seen between the frontopolar and temporal regions. In the theta band, highly significant edges also were found between the frontopolar and parietooccipital regions, and between the temporal regions bilaterally (Figures 3A–B). The alpha band contained the greatest number of significantly different connections (141 edges) and these linked brain regions that were more widely separated, including connections between the frontopolar or DLPFC and the temporal or parietooccipital regions bilaterally (Figure 3C). The beta band also contained a large number of significantly different
