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Chunk #73 — ONLINE METHODS — GWAS of Cognitive Performance, Math Ability and Highest Math.

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Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
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For Cognitive Performance, we conducted a sample-size-weighted meta-analysis (N = 257,841), imposing a minimum-sample-size filter of 100,000. We similarly applied minimum-sample-size filters to the Math Ability (N > 500,000) and Highest Math (N > 350,000) results. We adjusted the test statistics using the estimated intercepts from LD Score regressions (1.073 for Math Ability, 1.105 for Highest Math, and 1.046 for Cognitive Performance). The summary statistics underwent quality control using the same procedures applied to the EduYears results files.