In the phenome-wide association studies (PheWAS) using PsycheMERGE data, 58 phenotypes were significantly associated with the PAU PRS in EUR (Supplementary Table 17 and Extended Data Fig. 3). In AFR, AUD (odds ratio (OR) 1.25, s.e. 0.04 and P = 2.62 × 10−7), alcohol-related disorders (OR 1.21, s.e. 0.04 and P = 4.11 × 10−7) and tobacco use disorder (OR 1.09, s.e. 0.02 and P = 6.98 × 10−6) were significantly associated with AUD PRS (Supplementary Table 18 and Extended Data Fig. 4).
