range of p value thresholds (P ≤ 1 × 10−7, 1 × 10−6, 1 × 10−5, 1 × 10−4, 1 × 10−3, 0.01, 0.05, 0.5, 1.0). PRS were standardized with mean = 0 and SD = 1. Logistic regression was used to test for association with AUDIT-C and AUD phenotypes, with PRS as the independent variable and AUDIT-C or AUD as the dependent variable, with age, sex, and the first five PCs as covariates.
