The WTCCC [2007] identified six chromosomal regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27 associated with T1D at P < 5×10−7. Todd et al. [2007] genotyped 11 SNPs that had shown association with P < 1.64 × 10−5 from 11 chromosome regions not previously associated with T1D. They genotyped samples from 4,000 affected individuals and 5,000 controls that were independent of the WTCCC study [Todd et al. 2007]. We performed the bias correction methods on the 12 selected SNPs imposing the selection criteria P < 1.64 × 10−5 (Table 6). Six SNPs showed evidence for associations in the follow up study with P < 1.82×10−6 and effects in the same direction as in WTCCC. Their corrected OR estimates are similar or slightly less than the uncorrected OR estimates. The selection adjusted CIs for these SNPs are similar to the unadjusted CIs. Three SNPs showed evidence for associations in the follow-up study with p-values between 0.02 and 0.05. Their corrected OR estimates are less than the uncorrected OR estimates. The selection adjusted CIs are wider than the unadjusted CIs. However, the
