However, alcohol challenges are expensive and time-consuming to carry out, characteristics that preclude large scale studies of LR. In response to this problem, our group developed a 12-item retrospective self-report measure of LR, the Self-Report of the Effects of Alcohol (SRE) questionnaire, where a person records the number of standard (10–12 ounces of ethanol) drinks required across four possible effects as measured across three timeframes (Schuckit et al., 2018). The effects evaluated include the number of drinks to first feel any effect of alcohol, drinks required to actually experience slurring speech, unsteady gait, and unwanted falling asleep. The three timeframes evaluated are the approximate first five times of ad lib drinking, the period of heaviest alcohol consumption, and the most recent 3 months. The SRE instrument can be found in PhenX.