Chunk #43 — RESULTS — Hyperexcitability is reversed by chronic Li treatment of LR DG-like neurons but not of NR neurons, and Li treatment reduces cell capacitance in both LR and NR neurons
Analysis of the action potential shape revealed that chronic Li treatment also changed the action potential characteristics. Representative traces of an action potential acquired in current clamp mode are shown in Figure 6f (red, LR), 6 g (orange, LR lithium), 6n (purple, NR) and 6o (pink, NR lithium). Following chronic Li treatment, the spike amplitude did not change in either LR or NR DG-like neurons, although there was some reduction in the sodium currents of LR neurons, but this reduction was not very large in the − 60 to − 20 mV range, which is the range that affects the spike amplitude (Supplementary Figures 3c and j). The fast AHP amplitude decreased in both LR (−30%, P = 0.029) and NR neurons (−40%, P = 0.02) (Supplementary Figures 3d and k). The spike width broadened in the LR neurons (36%, P = 0.03), with an effect in the same direction in NR neurons (Supplementary Figures 3e and l), and the threshold for firing decreased in the NR neurons (3 mV less depolarized, P = 0.04) with an effect in the
