Chunk #42 — RESULTS — Hyperexcitability is reversed by chronic Li treatment of LR DG-like neurons but not of NR neurons, and Li treatment reduces cell capacitance in both LR and NR neurons
in voltage clamp mode of sodium and potassium currents are shown in Supplementary Figure 3a (LR), 3b (LR Li), 3 h (NR) and 3i (NR Li). The sodium current at −20 mV is shown in the inset of each figure. The sodium currents were reduced in LR neurons after Li treatment by ~ 10% (P = 0.03, two-way analysis of variance) but not in NR neurons (Figure 6c and k). Although the average across sodium currents in all holding potentials was reduced in LR neuron in response to Li treatment, the spike height was not expected to change, as at −60 to −20 mV there was no change to the sodium currents, and these are the potentials that influence mostly the spike height. The fast potassium currents were reduced by ~ 13% (P = 0.0078) and by ~ 6% in NR neurons (P = 0.005) (Figure 6d and l). The slow potassium currents did not change (Figure 6e and m).
