Our study shows that OUD treatment days were associated with reductions in overall odds of admissions for alcohol-related acute events (ie, falls, injuries, and poisonings). We observed risk reductions of 43% for buprenorphine and 66% for methadone treatment days. Extended-release and oral naltrexone treatment days were associated with 37% and 16% reductions, respectively. Naltrexone use was more prevalent among patients with OUD with existing AUD claims than their peers without such claims, consistent with naltrexone’s dual FDA indications of naltrexone for both AUD and OUD treatment. However, naltrexone and buprenorphine showed similar overall protective outcomes against alcohol-related acute events.
