In the stratified analysis, buprenorphine’s protective associations against alcohol-related acute events were more pronounced among patients with OUD with recent AUD claims (OR, 0.41; 95% CI, 0.36-0.46) than among peers without such claims (OR, 0.74; 95% CI, 0.66-0.83). In comparison, methadone exhibited similar protective associations in patients with OUD with (OR, 0.30; 95% CI, 0.20-0.45) and without (OR, 0.36; 95% CI, 0.25-0.53) recent AUD claims. The protective associations of extended-release naltrexone (OR, 0.56; 95% CI, 0.45-0.70) and oral naltrexone (OR, 0.79; 95% CI, 0.70-0.88) were significant only among patients with OUD with AUD, as opposed to peers without claims; however, differences in adjusted ORs by AUD status were not significant because of wide 95% CIs among patients with AUD. Across all analyses, the 2 forms of naltrexone did not significantly differ from one another in their association with alcohol-related acute events.
