Figure 2 shows the adjusted ORs of admissions for alcohol-related acute events associated with days using OUD medications vs nonmedication days. A full listing of point estimates and 95% CIs is enumerated in eTable 2 (unadjusted models) and eTable 3 (adjusted models) in the Supplement, with the association between OUD medication and alcohol-related acute events unchanged between unadjusted and adjusted analyses. Covariate adjustment had little impact on the other parameters in the model. Among agonist medications, buprenorphine was associated with a 43% reduction (OR, 0.57; 95% CI, 0.52-0.61) and methadone was associated a 66% reduction (OR, 0.34; 95% CI, 0.26-0.45) in adjusted odds of alcohol-related acute events. Among antagonist medication, oral naltrexone was associated with a 37% reduction (OR, 0.63; 95% CI, 0.52-0.76) and extended-release naltrexone was associated with a 16% reduction (OR, 0.84; 95% CI, 0.76-0.93) in the adjusted odds of such events.
