Most associations highlighted here have high colocalization probabilities. See Supplementary Tables 3, 4, and 5. However, visceral fat association shows evidence of non colocalization (probability of independent signals P3 = 0.69 in LDL-C). It is possible that the relevant regulatory activity in visceral adipose tissue was not detected in the GTEx samples for various reasons but it was detected in tibial nerve. Thus by looking into all tissues’ results we increase the window of opportunities where we can detect the association.
