Chunk #51 — Results — Agnostic scanning across GTEx tissues improves discovery

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Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.

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PCSK9 yields colocalized signals for LDL-C levels in Tibial Nerve, Lung, and Whole blood. SORT1 shows colocalization with LDL-C in liver (P4 ≈ 1) and pancreas (P4 = 0.90). C4A is colocalized with schizophrenia risk for the majority of the tissues (29/40) with a median colocalization probability of 0.82.