Chunk #22 — 3. Results — 3.1. CRHBP — 3.1.1. Main effects of CRHBP SNPs

Source: Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior.
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Using the whole dataset of genotyped individuals (N = 830) and including the dichotomous ‘substance dependence diagnosis’ as a covariate, there was no main effect of any of the CRHBP SNPs on suicidal behavior.