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Chunk #23 — 3. Results — 3.1. CRHBP — 3.1.2. Gene–environment (G × E) interactions

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Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior.
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These analyses were conducted on the 474 participants who had both CTQ data and DNA (Fig. 1). From Table 2 it can be seen that within the whole logistic regression model there was a main effect of rs6453267. This variant allele, unique to individuals of African ancestry (Table 1), was more common in non-suicide (0.23 vs 0.19, p = 0.007). The result remained of trend significance after FDR correction (p = 0.0504).