Chunk #24 — 3. Results — 3.1. CRHBP — 3.1.2. Gene–environment (G × E) interactions

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Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior.

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All the interactive analyses shown in Table 2 were performed with the total CTQ score, a continuous variable. There were nominally significant G × E interactive effects for rs7728378, rs10474485 and rs6453267 but after FDR correction, only the results for rs7728378 remained significant.