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Chunk #25 — 3. Results — 3.1. CRHBP — 3.1.2. Gene–environment (G × E) interactions

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Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior.
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For rs7728378 and rs10474485 the major homozygote interacted with total CTQ score to predict suicide attempt. In order to illustrate the direction of this interactive effect on suicide attempt the dichotomous total CTQ score was used, the derivation of which was described earlier. Since the MAF was high (0.39) for rs10474485 we were able to identify the direction of effect of all three genotypes. The prevalence of suicide attempt in carriers of the major homozygote, heterozygote and minor homozygote was as follows: high trauma: 0.54, 0.27, 0.32; low trauma: 0.17, 0.20, 0.17.