The logistic regression analyses were repeated in the substance dependent individuals (N = 303). Even though the sample size was smaller than the total sample (N = 474) similar G × E results were obtained for the CRHBP SNPs. Substance dependent vs total sample: rs1500: p = 0.026 vs 0.078; rs10474485: p = 0.038 vs 0.032; rs7728378: p = 0.054 vs 0.0098. The main effect of rs6453267 remained significant: p = 0.037 (uncorrected).
