In conclusion, all these observations emphasize that a deficiency in the cellular housekeeping can trigger the inflammatory danger sensor NLRP3, and also NLRP1 in some tissues like brain [60], and by this means stimulate inflammatory reactions in sensitive tissues. In this respect, the effective function of autophagic uptake and lysosomal degradation of dysfunctional mitochondria and aggregated proteins is a crucial element in maintaining tissue homeostasis. There are indications that autophagic capacity is compromised in certain diseases [61,62], e.g. in Alzheimer×s disease [63]. On the other hand, there is growing evidence implying that inflammasomes are activated in many pathological conditions [64,65] and thus a deficiency in autophagic housekeeping could trigger an inflammatory component and aggravate their pathogenesis.
