Inflammaging: disturbed interplay between autophagy and inflammasomes.

paper Cited Public

Authors: Salminen, Antero; Kaarniranta, Kai; Kauppinen, Anu
Year: 2012
Journal: Aging
PMID: 22411934
DOI: 10.18632/aging.100444
PMCID: PMC3348477

#	Section	Preview
0	Inflammaging	In 2000, Franceschi et al. [1] coined the term “inflammaging” in order to refer to a low-grade…
1	Inflammaging	It is known that systemic inflammation linked to inflammaging aggravates e.g. the vascular pathology…
2	Inflammasomes: molecular platforms for danger signal recognition	The aging process jeopardizes the maintenance of cellular homeostasis leading to the activation of a…
3	Inflammasomes: molecular platforms for danger signal recognition	inactive precursors of two proinflammatory cytokines, i.e. IL-1β and IL-18, into their mature forms…
4	Inflammasomes: molecular platforms for danger signal recognition	Infections and tissue injuries can trigger an inflammatory reaction as a physiological host defence…
5	Inflammasomes: molecular platforms for danger signal recognition	[26,27]. Furthermore, several studies have indicated that the release of cathepsin B after lysosomal…
6	Inflammasomes: molecular platforms for danger signal recognition	Recently, Wen et al. [32] demonstrated in macrophages that palmitate, a saturated fatty acid, could…
7	Inflammasomes: molecular platforms for danger signal recognition	Recently, Zhou et al. [37] demonstrated that mitochondria were crucially involved in the activation…
8	Autophagy: master of housekeeping prevents inflammasome activation	Autophagy is an ancient housekeeping mechanism which controls the cellular homeostasis by…
9	Autophagy: master of housekeeping prevents inflammasome activation	Several studies have clearly indicated that autophagy can suppress inflammatory reactions…
10	Autophagy: master of housekeeping prevents inflammasome activation	AMP-activated protein kinase (AMPK), can reduce inflammation and tissue pathology in several…
11	Autophagy: master of housekeeping prevents inflammasome activation	Mitochondria have a crucial role in the regulation of innate immunity responses [54,55]. In addition…
12	Autophagy: master of housekeeping prevents inflammasome activation	IL-18. They also observed that NLRP3 mediates the release of mtDNA which seems to function as a…
13	Autophagy: master of housekeeping prevents inflammasome activation	In conclusion, all these observations emphasize that a deficiency in the cellular housekeeping can…
14	Autophagy declines with aging enhancing the inflammaging process	The aging process involves a progressive decline in cellular and organismal function. The major…
15	Autophagy declines with aging enhancing the inflammaging process	Many studies have indicated that the inhibition of autophagy by genetic manipulation provokes…
16	Autophagy declines with aging enhancing the inflammaging process	Caloric restriction (CR) is the most common anti-aging intervention which can extend lifespan in…
17	Autophagy declines with aging enhancing the inflammaging process	There are several regulatory mechanisms which could augment the appearance of inflammaging phenotype…
18	Autophagy declines with aging enhancing the inflammaging process	In conclusion, the decline in autophagy during aging creates problems in cellular housekeeping…
19	Activators of autophagy: promising drugs for inflammaging and related diseases	As Cuervo [67] outlined, the role of autophagy is to “keep that old broom working” with aging.…

Name	Type
adrenal gland	anatomy
age-related cognitive impairment local	phenotype
Age-related cognitive impairment local	phenotype
age-related diseases	phenotype
age-related pathological changes local	phenotype
aging	phenotype
AICAR	drug
altered metabolic profile local	phenotype
Alzheimer's disease	phenotype
AMPK	gene
AMPK activators local	drug
Amyloid-beta peptide	drug
Anti-inflammaging local	phenotype
apoptosis	phenotype
ASC local	gene
ATG16L1 local	gene
ATG7 local	gene
atherosclerosis	phenotype
Autophagy	drug
Autophagy deficiency local	phenotype
Beclin 1 local	gene
Berberine local	drug
bone resorption	phenotype
brain	anatomy
Brain atrophy	phenotype
Caenorhabditis elegans	cohort
caloric restriction	phenotype
cancer	phenotype
cancer-prone mice local	cohort
cardiovascular disease	phenotype
CASP1	gene
CASP12 local	gene
CASP4	gene
CASP5 local	gene
cathepsin B local	gene
Chemotherapeutic drug treatment local	drug
cholesterol crystals local	drug
Cholesterol crystals local	drug
cortisol	drug
Crohn's disease	phenotype
CTSB local	gene
Curcumin local	drug
cytokines	drug
DAMPs	drug
decreased LAMP-2A expression local	phenotype
Degenerative disease	phenotype
diabetes	phenotype
Drosophila melanogaster	cohort
endoplasmic reticulum	anatomy
Everolimus local	drug
female mice	cohort
formyl peptides local	drug
FoxO3a	gene
frailty	phenotype
glucocorticoids	drug
Healthy old age local	phenotype
high-fat diet	drug
HPA axis	anatomy
Hutchinson-Gilford progeria cells local	phenotype
hypothalamus	anatomy
IAPP local	gene
IKBKB	gene
IKKα local	gene
IKKβ	gene
IL-18 local	drug
IL18 local	drug
IL18	gene
IL1B local	drug
IL1B	gene
IL-1β	drug
IL6	gene
immunosenescence local	phenotype
impaired chaperone-mediated autophagy local	phenotype
improved liver function local	phenotype
increased ROS production local	phenotype
inflammaging local	phenotype
Inflammaging local	phenotype
inflammasome local	phenotype
Inflammasome local	phenotype
inflammasome activation local	phenotype
Inflammasome activation local	phenotype
Inflammasomes local	phenotype
inflammation	phenotype
inflammatory bowel disease	phenotype
inflammatory response	phenotype
Innate immunity local	phenotype
insulin resistance	phenotype
insulin sensitivity	phenotype
IRGM	gene
LAMP2A local	gene
lifespan	phenotype
Lipid droplets local	drug
Lipofuscin	drug
longevity	phenotype
Lysosomal degradation local	phenotype
Lysosomal system local	drug
Metformin	drug
mice	cohort
Mitochondria	phenotype
mitochondrial disturbances local	phenotype
monkeys	cohort
mtDNA	drug
mTOR	gene
mTORC1 local	drug
mTOR inhibitors local	drug
NADPH oxidase	drug
NFKB local	drug
NFKB1	gene
NF-κB	gene
NIK local	gene
NLRP1 local	gene
NLRP3	gene
NLRX1 local	gene
Obese humans local	cohort
obesity	phenotype
Old rats local	cohort
Oleate local	drug
oxidative stress	phenotype
p62 local	gene
palmitate	drug
para-inflammation local	phenotype
pituitary gland	anatomy
potassium	drug
Premature aging phenotype local	phenotype
pro-inflammatory phenotype local	phenotype
Pro-inflammatory phenotype local	phenotype
Protein aggregates local	phenotype
Protein catabolism local	phenotype
Proteostasis local	phenotype
PYCARD local	gene
Quercetin local	drug
rapamycin	drug
Raptor local	gene
rats	cohort
reactive oxygen species	drug
reduced damaged proteins level local	phenotype
RIG-1-like receptor local	gene
ROS	drug
spatial learning and memory performance local	phenotype
SQSTM1 local	gene
Starvation local	drug
stroke	phenotype
Systemic inflammation local	phenotype
Temsirolimus local	drug
tissue injuries local	phenotype
tissue pathology local	phenotype
TNF	gene
TNF-α	drug
TRX local	gene
TSC2 local	gene
Tumor cell death local	phenotype
TXN local	gene
TXNIP	gene
type 2 diabetes	phenotype
ULK1 local	gene
Vascular pathology local	phenotype
VDAC2 local	gene
young mice	cohort

Citation	PMID	DOI	Status
Adler, AS et al., Genes Dev, 2007, Motif module map reveals enforcement of aging by continual NF-κB activity	18055696	10.1101/gad.1588507	Cited
Anisimov, VN et al., Am. J. Pathol, 2010, Rapamycin extends maximal lifespan in cancer-prone mice	20363920	10.2353/ajpath.2010.091050	Cited
Anisimov, VN et al., Cell Cycle, 2011, Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice	22107964	10.4161/cc.10.24.18486	Cited
Arnoult, D et al., EMBO Rep, 2011, Mitochondria in innate immunity	21799518	10.1038/embor.2011.157	Cited
Bauernfeind, F et al., Cell. Mol. Life Sci, 2011, Inflammasomes: current understanding and open questions	21072676	10.1007/s00018-010-0567-4	Cited
Bauernfeind, FG et al., J. Immunol, 2009, Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression	19570822	10.4049/jimmunol.0901363	Cited
Benjamin, D et al., Nat. Rev. Drug Discov, 2011, Rapamycin passes the torch: a new generation of mTOR inhibitors	22037041	10.1038/nrd3531	Cited
Bergamini, E et al., Ann. N.Y. Acad. Sci, 2007, The role of autophagy in aging: its essential part in the anti-aging mechanism of caloric restriction	17934054	10.1196/annals.1396.020	Cited
Bishop, NA et al., Nat. Rev. Genet, 2007, Genetic links between diet and lifespan: shared mechanisms from yeast to humans	17909538	10.1038/nrg2188	Cited
Bjorkoy, G et al., Autophagy, 2006, p62/SQSTM1: a missing link between protein aggregates and the autophagy machinery	16874037	10.4161/auto.2.2.2405	Cited
Blagosklonny, MV, Cell Cycle, 2008, Aging. ROS or TOR	18971624	10.4161/cc.7.21.6965	Cited
Blagosklonny, MV, Cell Cycle, 2010, Calorie restriction. Decelerating mTOR-driven aging from cells to organisms (including humans)	20139716	10.4161/cc.9.4.10766	Cited
Blagosklonny, MV, Cell Cycle, Rapamycin and quasi-programmed aging. Four years later	20436272	10.4161/cc.9.10.11872	Cited
Brunk, UT et al., Eur. J. Biochem, 2002, The mitochondrial-lysosomal axis theory of aging. Accumulation of damaged mitochondria as a result of imperfect autophagocytosis	11985575	10.1046/j.1432-1033.2002.02869.x	Cited
Busillo, JM et al., J. Biol. Chem, 2011, Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome	21940629	10.1074/jbc.M111.275370	Cited
Cao, K et al., Sci. Transl. Med, 2011, Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells	21715679	10.1126/scitranslmed.3002346	Cited
Cevenini, E et al., Curr. Pharm. Des, 2010, Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches	20388071	10.2174/138161210790883840	Cited
Chen, G et al., Annu. Rev. Pathol. Mech. Dis, 2009, NOD-like receptors: role in innate immunity and inflammatory disease	18928408	10.1146/annurev.pathol.4.110807.092239	Cited
Choi, AJS et al., Int. J. Cell Biol, 2011, Autophagy in inflammatory diseases	22190939	10.1155/2011/732798	Cited
Colman, TJ et al., Science, 2009, Caloric restriction delays disease onset and mortality in rhesus monkeys	19590001	10.1126/science.1173635	Cited
Cruz, CM et al., J. Biol. Chem, 2007, ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages	17132626	10.1074/jbc.M608083200	Cited
Csiszar, A et al., 2003, Aging-induced proinflammatory shift in cytokine expression profile in rat coronary arteries	12709402	10.1096/fj.02-1049fje	Cited
Cuervo, AM et al., J. Biol. Chem, 2000, Age-related decline in chaperone-mediated autophagy	10806201	10.1074/jbc.M002102200	Cited
Cuervo, AM, Trends Genet, 2008, Autophagy and aging: keeping that old broom working	18992957	10.1016/j.tig.2008.10.002	Cited
Davis, BK et al., Annu. Rev. Immunol, 2011, The inflammasome NLRs in immunity, inflammation, and associated diseases	21219188	10.1146/annurev-immunol-031210-101405	Cited
de Magalhaes, JP et al., Bioinformatics, 2009, Meta-analysis of age-related gene expression profiles identifies common signatures of aging	19189975	10.1093/bioinformatics/btp073	Cited
de Rivero Vaccari, JP et al., J. Cereb. Blood Flow Metab, 2009, Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after brain injury	19401709	10.1038/jcbfm.2009.46	Cited
Deretic, V, Cell Biol, 2010, Autophagy in infection. Curr. Opin	20116986	10.1016/j.ceb.2009.12.009	Cited
Deretic, V, Curr. Opin. Immunol, 2009, Multiple regulatory and effector roles of autophagy in immunity	19269148	10.1016/j.coi.2009.02.002	Cited
Djavaheri-Mergny, M et al., J. Biol. Chem, 2006, NF-κB activation represses tumor necrosis factor-α-induced autophagy	16857678	10.1074/jbc.M602097200	Cited
Dong, H et al., Metab, 2011, Regulation of lipid droplets by autophagy. Trends Endocrinol	21419642	10.1016/j.tem.2011.02.003	Cited
Egan, DF et al., Science, 2011, Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy	21205641	10.1126/science.1196371	Cited
Fesus, L et al., Redox Signal, 2011, Autophagy shapes inflammation. Antioxid	20812858	10.1089/ars.2010.3485	Cited
Fogarty, S et al., Biochim. Biophys. Acta, 2010, Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer	19778642	10.1016/j.bbapap.2009.09.012	Cited
Franceschi, C et al., Ann. NY. Acad. Sci, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence	10911963	10.1111/j.1749-6632.2000.tb06651.x	Cited
Franceschi, C et al., Mech. Age. Dev, 2007, Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans	17116321	10.1016/j.mad.2006.11.016	Cited
Giunta, G, Inflamm. Res, 2008, Exploring the complex relations between inflammation and aging (inflamm-aging): anti-inflamm-aging remodelling of inflamm-aging, from robustness to frailty	19109735	10.1007/s00011-008-7243-2	Cited
Gloire, G et al., Biochem. Pharmacol, 2006, NF-κB activation by reactive oxygen species: fifteen years later	16723122	10.1016/j.bcp.2006.04.011	Cited
Green, DR et al., Science, 2011, Mitochondria and the autophagy-inflammation-cell death axis in organismal aging	21868666	10.1126/science.1201940	Cited
Gross, O et al., Immunol. Rev, 2011, The inflammasome: an integrated view	21884173	10.1111/j.1600-065X.2011.01046.x	Cited
Hagopian, K et al., J. Bioenerg. Biomembr, 2011, Caloric restriction influences hydrogen peroxide generation in mitochondrial sub-populations from mouse liver	21505800	10.1007/s10863-011-9353-8	Cited
Halle, A et al., Nature Immunol, 2008, The NALP3 inflammasome is involved in the innate immune response to amyloid-ß	18604209	10.1038/ni.1636	Cited
Harrison, DE et al., Nature, 2009, Rapamycin fed late in life extends lifespan in genetically heterogeneous mice	19587680	10.1038/nature08221	Cited
He, C et al., Annu. Rev. Genet, 2009, Regulation mechanisms and signaling pathways of autophagy	19653858	10.1146/annurev-genet-102808-114910	Cited
Helenius, M et al., Biochem. J, 1996, Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB	8809053	10.1042/bj3180603	Cited
Holloszy, JO et al., Exp. Gerontol, 2007, Caloric restriction in humans	17482403	10.1016/j.exger.2007.03.009	Cited
Hsieh, CH et al., Ann. Surg, 2011, Complete induction of autophagy is essential for cardioprotection in sepsis	21412148	10.1097/SLA.0b013e318214b67e	Cited
Jia, K et al., Autophagy, 2007, Autophagy is required for dietary restriction-mediated life span extension in C. elegans	17912023	10.4161/auto.4989	Cited
Jo, EK et al., Microbes Infect, 2012, Autophagy: cellular defence to excessive inflammation	21924374	10.1016/j.micinf.2011.08.014	Cited
Johansen, T et al., Autophagy, 2011, Selective autophagy mediated by autophagic adapter proteins	21189453	10.4161/auto.7.3.14487	Cited
Kapahi, P et al., Cell Metab, 2010, With TOR, Less is more: a key role for the conserved nutrient-sensing TOR pathway in Aging	20519118	10.1016/j.cmet.2010.05.001	Cited
Kersse, K et al., Cytokine Growth Factor Rev, 2011, NOD-like receptors and the innate immune system: coping with danger, damage and death	21996492	10.1016/j.cytogfr.2011.09.003	Cited
Kovacs, EJ et al., Trends Immunol, 2009, Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors	19541536	10.1016/j.it.2009.03.012	Cited
Krabbe, KS et al., Exp. Gerontol, 2004, Inflammatory mediators in the elderly	15130663	10.1016/j.exger.2004.01.009	Cited
Kroemer, G et al., Nat. Rev. Mol. Cell Biol, 2008, Autophagic cell death: the story of a misnomer	18971948	10.1038/nrm2527	Cited
Krysko, DV et al., Trends Immunol, 2011, Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation	21334975	10.1016/j.it.2011.01.005	Cited
Lamkanfi, M et al., Immunol. Rev, 2011, Deregulated inflammasome signaling in disease	21884175	10.1111/j.1600-065X.2011.01042.x	Cited
Larbi, A et al., Physiology, 2008, Aging of the immune system as a prognostic factor for human longevity	18400689	10.1152/physiol.00040.2007	Cited
Lee, HM et al., J. Immunol, 2011, Autophagy negatively regulates keratinocytes inflammatory responses via scaffolding protein p62/SQSTM1	21160040	10.4049/jimmunol.1001954	Cited
Lee, JW et al., PLoS One, 2010, The association of AMPK with ULK1 regulates autophagy	21072212	10.1371/journal.pone.0015394	Cited
Levine, B et al., Cell, 2008, Autophagy in the pathogenesis of disease	18191218	10.1016/j.cell.2007.12.018	Cited
Levine, B et al., Nature, 2011, Autophagy in immunity and inflammation	21248839	10.1038/nature09782	Cited
Liu, F et al., Age (Dordr), 2012, Age-related changes in AMP-activated protein kinase after stroke	21360073	10.1007/s11357-011-9214-8	Cited
Madeo, F et al., Nat. Cell Biol, 2010, Can autophagy promote longevity?	20811357	10.1038/ncb0910-842	Cited
Majumder, S et al., Aging Cell, 2012, Life-long rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and NMDA signaling	22212527	10.1111/j.1474-9726.2011.00791.x	Cited
Martinez-Vicente, M et al., Lancet Neurol, 2007, Autophagy and neurodegeneration: when the cleaning crew goes on strike	17362839	10.1016/S1474-4422(07)70076-5	Cited
Martinon, F et al., Cell Death Differ, 2007, Inflammatory caspases and inflammasomes: master switches of inflammation	16977329	10.1038/sj.cdd.4402038	Cited
Masters, SL et al., Trends Mol. Med, 2011, Disease-associated amyloid and misfolded protein aggregates activate the inflammasome	21376667	10.1016/j.molmed.2011.01.005	Cited
Mawhinney, LJ et al., BMC Neurosci, 2011, Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats	22133203	10.1186/1471-2202-12-123	Cited
Medzhitov, R, Nature, 2008, Origin and physiological roles of inflammation	18650913	10.1038/nature07201	Cited
Meng, Q et al., J. Biol. Chem, 2011, Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IκB kinase β (IKKβ)/NF-κB pathway	21784844	10.1074/jbc.M111.254417	Cited
Mihaylova, MM et al., Nat. Cell Biol, 2011, The AMPK signalling pathway coordinates cell growth, autophagy and metabolism	21892142	10.1038/ncb2329	Cited
Morgan, MJ et al., Cell Res, 2011, Crosstalk of reactive oxygen species and NF-κB signaling	21187859	10.1038/cr.2010.178	Cited
Morgan, TE et al., Interdiscip. Top. Gerontol, 2007, Anti-inflammatory mechanisms of dietary restriction in slowing aging processes	17063034	10.1159/000096557	Cited
Moscat, J et al., Trends Biochem. Sci, 2007, Signal integration and diversification through the p62 scaffold protein	17174552	10.1016/j.tibs.2006.12.002	Cited
Nakahira, K et al., Nat. Immunol, 2011, Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome	21151103	10.1038/ni.1980	Cited
Niemi, K et al., J. Immunol, 2011, Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and cathepsin B-sensitive pathway	21508263	10.4049/jimmunol.1002843	Cited
Niida, M et al., Mol. Immunol, 2010, Downregulation of active IKKβ by Ro52-mediated autophagy	20627395	10.1016/j.molimm.2010.05.004	Cited
Nixon, RA et al., Neurobiol. Dis, 2011, Autophagy failure in Alzheimer's disease - locating the primary defect	21296668	10.1016/j.nbd.2011.01.021	Cited
Notte, A et al., Biochem. Pharmacol, 2011, Autophagy as a mediator of chemotherapy-induced cell death in cancer	21704023	10.1016/j.bcp.2011.06.015	Cited
Page, MM et al., Mech. Ageing Dev, 2010, Mitochondrial redox metabolism: aging, longevity and dietary effects	20219522	10.1016/j.mad.2010.02.005	Cited
Pantano, C et al., Antioxid. Redox Signal, 2006, Redox-sensitive kinases of the nuclear factor-κB signaling pathway	16987032	10.1089/ars.2006.8.1791	Cited
Petrilli, V et al., Cell Death Differ, 2007, Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration	17599094	10.1038/sj.cdd.4402195	Cited
Piva, R et al., Redox Signal, 2006, NF-κB: a stress-regulated switch for cell survival. Antioxid	16677091	10.1089/ars.2006.8.478	Cited
Qing, G et al., Cell Res, 2006, Hsp90 inhibition results in autophagy-mediated proteasomes-independent degradation of IκB kinase (IKK)	17088896	10.1038/sj.cr.7310109	Cited
Qing, G et al., Cell Res, 2007, Hsp90 regulates processing of NF-κB2 p100 involving protection of NF-κB-inducing kinase (NIK) from autophagy-mediated degradation	17563756	10.1038/cr.2007.47	Cited
Rajamäki, K et al., PLoS One, 2010, Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation	20668705	10.1371/journal.pone.0011765	Cited
Rajawat, YS et al., Ageing Res. Rev, 2009, Aging: Central role for autophagy and the lysosomal degradative system	19427410	10.1016/j.arr.2009.05.001	Cited
Ravikumar, B et al., Physiol. Rev, 2010, Regulation of mammalian autophagy in physiology and pathophysiology	20959619	10.1152/physrev.00030.2009	Cited
Reznick, RM et al., Cell. Metab, 2007, Aging-associated reductions in AMPK-activated protein kinase activity and mitochondrial biogenesis	17276357	10.1016/j.cmet.2007.01.008	Cited
Rezzani, R et al., Ageing Res. Rev, 2012, Morphological and biochemical studies on aging and autophagy	21939784	10.1016/j.arr.2011.09.001	Cited
Rubinsztein, DC et al., Cell, 2011, Autophagy and aging	21884931	10.1016/j.cell.2011.07.030	Cited
Saitoh, T et al., Nature, 2008, Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production	18849965	10.1038/nature07383	Cited
Salminen, A et al., Ageing Res. Rev, 2008, Activation of innate immunity system during aging: NF-κB signaling is the culprit of inflamm-aging	17964225	10.1016/j.arr.2007.09.002	Cited
Salminen, A et al., Ageing Res. Rev, 2012, AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network	22186033	10.1016/j.arr.2011.12.005	Cited
Salminen, A et al., J. Mol. Med. (Berl.), 2011, AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan	21431325	10.1007/s00109-011-0748-0	Cited
Salminen, A et al., Trends Mol. Med, 2009, Regulation of the aging process by autophagy	19380253	10.1016/j.molmed.2009.03.004	Cited
Sanchez, AM et al., J. Cell. Biochem, 2012, AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1	22006269	10.1002/jcb.23399	Cited
Scherz-Shouval, R et al., Trends Biochem. Sci, 2011, Regulation of autophagy by ROS: physiology and pathology	20728362	10.1016/j.tibs.2010.07.007	Cited
Schroder, K et al., Cell, 2010, The inflammasomes	20303873	10.1016/j.cell.2010.01.040	Cited
Schroder, K et al., Science, 2010, The NLRP3 inflammasome: a sensor for metabolic danger?	20075245	10.1126/science.1184003	Cited
Seo, AY et al., J. Cell Sci, 2010, New insights into the role of mitochondria in aging: mitochondrial dynamics and more	20940129	10.1242/jcs.070490	Cited
Shi, CS et al., Nat. Immunol, 2012, Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction	22286270	10.1038/ni.2215	Cited
Shimizu, S et al., Oncogene, 2010, Involvement of JNK in the regulation of autophagic cell death	20101227	10.1038/onc.2009.487	Cited
Simonsen, A et al., Autophagy, 2008, Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila	18059160	10.4161/auto.5269	Cited
Singh, R et al., Cell Metab, 2011, Autophagy in the cellular energetic balance	21531332	10.1016/j.cmet.2011.04.004	Cited
Singh, T et al., Ageing Res. Rev, 2010, Inflammatory markers in population studies of aging	21145432	10.1016/j.arr.2010.11.002	Cited
Steinberg, GR et al., Physiol. Rev, 2009, AMPK in health and disease	19584320	10.1152/physrev.00011.2008	Cited
Stienstra, R et al., Proc. Natl. Acad. Sci. USA, 2011, Inflammasome is a central player in the induction of obesity and insulin resistance	21876127	10.1073/pnas.1100255108	Cited
Swindell, WR, BMC Genomics, 2009, Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse	19968875	10.1186/1471-2164-10-585	Cited
Toth, ML et al., Autophagy, 2008, Lonevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans	18219227	10.4161/auto.5618	Cited
Trifunovic, A et al., Nature, 2004, Premature ageing in mice expressing defective mitochondrial DNA polymerase	15164064	10.1038/nature02517	Cited
Tsang, CK et al., Drug Discov. Today, 2007, Targeting mammalian target of rapamycin (mTOR) for health and diseases	17275731	10.1016/j.drudis.2006.12.008	Cited
Tschopp, J et al., Nat. Rev. Immunol, 2010, NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?	20168318	10.1038/nri2725	Cited
Vandanmagsar, B et al., Nat. Med, 2011, The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance	21217695	10.1038/nm.2279	Cited
Vingtdeux, V et al., FASEB J, 2011, Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation	20852062	10.1096/fj.10-167361	Cited
Weber, TA et al., Exp. Gerontol, 2010, Impaired quality control of mitochondria: aging from a new perspective	20451598	10.1016/j.exger.2010.03.018	Cited
Wen, H et al., Nat. Immunol, 2011, Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling	21478880	10.1038/ni.2022	Cited
West, AP et al., Nat. Rev. Immunol, 2011, Mitochondria in innate immune responses	21597473	10.1038/nri2975	Cited
Wu, JJ et al., Aging (Albany NY), 2009, Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy	20157526	10.18632/aging.100038	Cited
Xiang, M et al., J. Immunol, 2011, Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells	21940680	10.4049/jimmunol.1102093	Cited
Yang, L et al., Cell Metab, 2010, Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance	20519119	10.1016/j.cmet.2010.04.005	Cited
Yazdi, AS et al., J. Innate Immun, 2010, Inflammatory caspases in innate immunity and inflammation	20375549	10.1159/000283688	Cited
Yoshizaki, T et al., Biochem. Biophys. Res. Commun, 2012, Autophagy regulates inflammation in adipocytes	22155234	10.1016/j.bbrc.2011.11.114	Cited
Zhang, C et al., Nat. Med, 2008, Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function	18690243	10.1038/nm.1851	Cited
Zhou, R et al., Nat. Immunol, 2010, Thioredoxin-interacting protein links oxidative stress to inflammasome activation	20023662	10.1038/ni.1831	Cited
Zhou, R et al., Nature, 2011, A role for mitochondria in NLRP3 inflammasome activation	21124315	10.1038/nature09663	Cited
Zoncu, R et al., Cell Biol, 2011, mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol	21157483	10.1038/nrm3025	Cited

In this knowledge base

Title	Year	PMID
Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook.	2019	30087005
Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells.	2016	27160314

External

Title	Authors	Journal	Year	Link
Aging at the Crossroads of Cuproptosis and Ferroptosis: From Molecular Pathways to Age-Related Pathologies and Therapeutic Perspectives.	Gromadzka G et al.	—	2026	→
CD8<sup>+</sup> T cell aging, senescence, and related disease.	He Z et al.	—	2026	→
Inflammageing and clonal haematopoiesis interplay and their impact on human disease.	Hajishengallis G et al.	—	2026	→
NAD⁺ as a central metabolic hub Regulating the hallmarks of aging: Mechanisms and therapeutic implications.	Pei Z et al.	—	2026	→
NLRP3 inflammasome dysregulation by endocrine-disrupting chemicals and heavy metals: Developmental programming, sex differences, and inflammaging across the lifespan.	Karpuzoglu E et al.	—	2026	→
Age-related differences in long-term memory performance and astrocyte morphology in rat hippocampus.	Martins YA et al.	—	2025	→
Anthraquinones and Aloe Vera Extracts as Potential Modulators of Inflammaging Mechanisms: A Translational Approach from Autoimmune to Onco-Hematological Diseases.	Cordiano R et al.	—	2025	→
ANXA2 regulates mitochondrial function and cellular senescence of PDLCs via AKT/eNOS signaling pathway under high glucose conditions.	Huang Y et al.	—	2025	→
Circadian Rhythms and Lung Cancer in the Context of Aging: A Review of Current Evidence.	Xu W et al.	—	2025	→
Effects of Long-term low-dose intermittent rapamycin administration on glucose metabolism and immune system of SAMP8 and SAMR1 mice.	Queiroz LAD et al.	—	2025	→
Emerging role of ferroptosis in ultraviolet radiation-driven skin photoaging: a narrative review.	Teng Y et al.	—	2025	→
Exploring the Regulatory Effect of Hydroxytyrosol on Ovarian Inflammaging Through Autophagy-Targeted Mechanisms: A Bioinformatics Approach.	An X et al.	—	2025	→
From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction.	De Luca F et al.	—	2025	→
Germinal center immune dynamics: challenges for effective vaccination in the elderly.	Brenna C et al.	—	2025	→
Hyperfunctional Neutrophils in Aged Mice Are Linked to Enhanced Bone Loss in Ligature-Induced Periodontitis.	Magne A et al.	—	2025	→
Impact of Areca Catechu Kombucha on Inflammatory Markers and Gut Microbiota - a Review.	Ariestine DA et al.	—	2025	→
Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle-serving nerves and spinal cord.	Drosen ME et al.	—	2025	→
Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial.	Gaudilliere B et al.	—	2025	→
Mechanotransduction for therapeutic approaches: Cellular aging and rejuvenation.	Han HM et al.	—	2025	→
Metformin Exhibits Anti-Inflammatory Effects by Regulating microRNA-451/CXCL16 and B Cell Leukemia/Lymphoma 2 in Patients With Osteoarthritis.	Alimoradi N et al.	—	2025	→
Molecular and Environmental Modulators of Aging: Interplay Between Inflammation, Epigenetics, and RNA Stability.	Dragoumani K et al.	—	2025	→
Molecular Aspects of Geriatric Pharmacotherapy.	Rzeczycki P et al.	—	2025	→
Possible Anti-Aging and Anti-Stress Effects of Long-Term Transcendental Meditation Practice: Differences in Gene Expression, EEG Correlates of Cognitive Function, and Hair Steroids.	Wenuganen S et al.	—	2025	→
Programmed Cell Death of Chondrocytes, Synovial Cells, Osteoclasts, and Subchondral Bone Cells in Osteoarthritis.	Huang J et al.	—	2025	→
Protein hydrolysate from Atlantic salmon (Salmo salar) improves aging-associated neuroinflammation and cognitive decline in rats by reshaping the gut microbiota and Th17/Treg balance.	Guan MQ et al.	—	2025	→
Reading the immune clock: a machine learning model predicts mouse immune age from cellular patterns.	Sim HB et al.	—	2025	→
RNA G-quadruplex (rG4) exacerbates cellular senescence by mediating ribosome pausing.	Zhou H et al.	—	2025	→
The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan.	Gkioni L et al.	—	2025	→
The Role of Ginseng and Its Bioactive Compounds in Aging: Cells and Animal Studies.	Lee DY et al.	—	2025	→
Transcription Factor EB SUMOylation in Airway Epithelial Cells Impairs Lysosomal Biogenesis to Promote Asthma Development.	Yu Q et al.	—	2025	→
Transcriptomic evidence from peripheral blood reveals nonlinear gene expression trajectories of aging in female rhesus macaques.	Weng CJ et al.	—	2025	→
Vital Role of Visceral Adipose Tissue in Maintaining Cognitive Functions.	Shirafuji R et al.	—	2025	→
A Perfect Storm: The Convergence of Aging, Human Immunodeficiency Virus Infection, and Inflammasome Dysregulation.	Thirugnanam S et al.	—	2024	→
Chemokine CXCL9, a marker of inflammaging, is associated with changes of muscle strength and mortality in older men.	Seo DH et al.	—	2024	→
Color Doppler Imaging, Endothelin-1, Corneal Biomechanics and Scleral Rigidity in Asymmetric Age-Related Macular Degeneration.	Finzi A et al.	—	2024	→
Deoxynivalenol induces cell senescence in RAW264.7 macrophages via HIF-1α-mediated activation of the p53/p21 pathway.	Li J et al.	—	2024	→
DYSREGULATION OF AUTOPHAGY IN PERIPHERAL BLOOD LEUCOCYTES IS A FACTOR IN THE DEVELOPMENT OF INFLAMMAGING IN IMMUNOCOMPROMISED PERSONS ON THE EXAMPLE OF THE SERVICEMEN OF THE DEFENSE FORCES OF UKRAINE AND CLEAN-UP WORKERS OF THE CHORNOBYL ACCIDENT.	Zvarych LM et al.	—	2024	→
Effects of low-dose rapamycin on lymphoid organs of mice prone and resistant to accelerated senescence.	Barros RDS et al.	—	2024	→
Exploratory Review of the Takotsubo Syndrome and the Possible Role of the Psychosocial Stress Response and Inflammaging.	Frank N et al.	—	2024	→
Exploring the role of autophagy in psoriasis pathogenesis: Insights into sustained inflammation and dysfunctional keratinocyte differentiation.	Wu X et al.	—	2024	→
From premature birth to premature kidney disease: does accelerated aging play a role?	Sanderson KR et al.	—	2024	→
Georgian Medicinal Plants as Rich Natural Sources of Antioxidant Derivatives: A Review on the Current Knowledge and Future Perspectives.	Pirtskhalava M et al.	—	2024	→
Immunosenescence and inflammaging: Mechanisms and role in diseases.	Ajoolabady A et al.	—	2024	→
Involvement of Melatonin, Oxidative Stress, and Inflammation in the Protective Mechanism of the Carotid Artery over the Torpor-Arousal Cycle of Ground Squirrels.	Hao Z et al.	—	2024	→
Miao medicine Gu Yan Xiao tincture inhibits mTOR to stimulate chondrocyte autophagy in a rabbit model of osteoarthritis.	Cai H et al.	—	2024	→
Mitochondrial dysfunction and NLRP3 inflammasome: key players in kidney stone formation.	Su B et al.	—	2024	→
Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease Implications.	Lin J et al.	—	2024	→
Naringenin, a flavanone constituent from Sea buckthorn pulp extract, prevents ultraviolet (UV)-B radiation-induced skin damage via alleviation of impaired mitochondrial dynamics mediated inflammation in human dermal fibroblasts and Balb/c mice models.	Sajeeda A et al.	—	2024	→
Non-coding RNAs as regulators of autophagy in chondrocytes: Mechanisms and implications for osteoarthritis.	Zhu C et al.	—	2024	→
Pathological mechanisms of kidney disease in ageing.	Yamamoto T et al.	—	2024	→
Potential application of traditional Chinese medicine in age-related macular degeneration-focusing on mitophagy.	Yu Y et al.	—	2024	→
Recent advances in anti-inflammation via AMPK activation.	Xu Y et al.	—	2024	→
The Impact of Aging on Neurological Diseases in the Elderly: Molecular Mechanisms and Therapeutic Perspectives.	Zhou D et al.	—	2024	→
The role of oxygen tension in cell fate and regenerative medicine: implications of hypoxia/hyperoxia and free radicals.	Rasouli M et al.	—	2024	→
Age-associated inflammation and implications for skeletal muscle responses to exercise.	Kunz HE et al.	—	2023	→
Anti-ageing effects of FDA-approved medicines: a focused review.	Thanapairoje K et al.	—	2023	→
Applications of mesenchymal stem cells in ocular surface diseases: sources and routes of delivery.	Soleimani M et al.	—	2023	→
Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view.	Raee P et al.	—	2023	→
Biomarkers of aging.	Aging Biomarker Consortium et al.	—	2023	→
Can accelerated ageing models inform us on age-related tauopathies?	Han ZZ et al.	—	2023	→
COVID-19: A Comprehensive Review on Cardiovascular Alterations, Immunity, and Therapeutics in Older Adults.	Rivera-Torres J et al.	—	2023	→
Dysfunction of the aging female mouse urethra is associated with striated muscle loss and increased fibrosis: an initial report.	Sadeghi Z et al.	—	2023	→
Epigenetic Modifications of MiRNAs in Osteoarthritis: A Systematic Review on Their Methylation Levels and Effects on Chondrocytes, Extracellular Matrix and Joint Inflammation.	Veronesi F et al.	—	2023	→
Evolutionary and genomic perspectives of brain aging and neurodegenerative diseases.	Rigby Dames BA et al.	—	2023	→
From Youthful Vigor to Aging Decline: Unravelling the Intrinsic and Extrinsic Determinants of Hippocampal Neural Stem Cell Aging.	Jiménez Peinado P et al.	—	2023	→
Hydroxytyrosol Interference with Inflammaging via Modulation of Inflammation and Autophagy.	Velotti F et al.	—	2023	→
Mechanistic role and potential of Ayurvedic herbs as anti-aging therapies.	Raina K et al.	—	2023	→
Mechanistic role and potential of Ayurvedic herbs as anti-aging therapies.	Raina K et al.	—	2023	→
Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory.	Meng G et al.	—	2023	→
Microbiota-immune-brain interactions: A lifespan perspective.	Ratsika A et al.	—	2023	→
Morphofunctional Investigation in a Transgenic Mouse Model of Alzheimer's Disease: Non-Reactive Astrocytes Are Involved in Aβ Load and Reactive Astrocytes in Plaque Build-Up.	Lana D et al.	—	2023	→
P2X7Rs: new therapeutic targets for osteoporosis.	Huang H et al.	—	2023	→
Perinatal Obesity Sensitizes for Premature Kidney Aging Signaling.	Selle J et al.	—	2023	→
Protocatechuic Aldehyde Alleviates d -Galactose-Induced Cardiomyocyte Senescence by Regulating the TCF3/ATG5 Axis.	Wang P et al.	—	2023	→
Regulation of autophagy by circular RNAs in rheumatoid arthritis: Potential targets of action.	Hu Y et al.	—	2023	→
Sedentary behavior and the biological hallmarks of aging.	Raffin J et al.	—	2023	→
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection.	Polcz VE et al.	—	2023	→
The impact of age-related syndromes on ICU process and outcomes in very old patients.	Vallet H et al.	—	2023	→
The multifactorial nature of healthy brain ageing: Brain changes, functional decline and protective factors.	Turrini S et al.	—	2023	→
The role of autophagy protein Atg5 in multiple sclerosis.	Baeva ME et al.	—	2023	→
The rosetta stone of successful ageing: does oral health have a role?	Poser M et al.	—	2023	→
Tranexamic acid improves psoriasis-like skin inflammation: Evidence from in vivo and in vitro studies.	Hseu JH et al.	—	2023	→
Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans.	Roberts AL et al.	—	2022	→
Age acquired skewed X Chromosome Inactivation is associated with adverse health outcomes in humans	Roberts AL et al.	—	2022	—
Age-Related Changes in the Fibroblastic Differon of the Dermis: Role in Skin Aging.	Zorina A et al.	—	2022	→
A Systematic Review and Meta-analysis Examining the Impact of Age on Perioperative Inflammatory Biomarkers.	Patel A et al.	—	2022	→
Autophagy in aging-related oral diseases.	Peña-Oyarzún D et al.	—	2022	→
Biomarkers of ageing and frailty may predict COVID-19 severity.	Wanhella KJ et al.	—	2022	→
Biomarkers of aging in real life: three questions on aging and the comprehensive geriatric assessment.	Zampino M et al.	—	2022	→
Cellular senescence is a key mediator of lung aging and susceptibility to infection.	Torrance BL et al.	—	2022	→
Cochlear Immune Response in Presbyacusis: a Focus on Dysregulation of Macrophage Activity.	Noble K et al.	—	2022	→
Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice.	Shyu YC et al.	—	2022	→
Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer's disease.	Shao L et al.	—	2022	→
HIV and cardiovascular disease: the role of inflammation.	Dirajlal-Fargo S et al.	—	2022	→
Identification of Four Biomarkers of Human Skin Aging by Comprehensive Single Cell Transcriptome, Transcriptome, and Proteomics.	Mao R et al.	—	2022	→
Immunohistochemical Expression of p62 in Feline Mammary Carcinoma and Non-Neoplastic Mammary Tissue.	Magi GE et al.	—	2022	→
Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction.	Rasa SMM et al.	—	2022	→
Interplay between Inflammaging, Frailty and Nutrition in Covid-19: Preventive and Adjuvant Treatment Perspectives.	Padilha de Lima A et al.	—	2022	→
Meals That Differ in Nutrient Composition and Inflammatory Potential Do Not Differentially Impact Postprandial Circulating Cytokines in Older Adults above a Healthy Weight.	Cowan S et al.	—	2022	→
Mechanisms Involved in Gut Microbiota Regulation of Skeletal Muscle.	Li G et al.	—	2022	→
Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control.	Dantas WS et al.	—	2022	→
Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice.	Britton R et al.	—	2022	→
Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes.	He Y et al.	—	2022	→
Remodeling Osteoarthritic Articular Cartilage under Hypoxic Conditions.	Mohd Yunus MH et al.	—	2022	→
Role of ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis.	Liu Y et al.	—	2022	→
Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses.	Frasca D	—	2022	→
Somatic Mutations of Hematopoietic Cells Are an Additional Mechanism of Body Aging, Conducive to Comorbidity and Increasing Chronification of Inflammation.	Yegorov YE et al.	—	2022	→
Stem Cell-Based Therapeutic Strategies for Premature Ovarian Insufficiency and Infertility: A Focus on Aging.	Ali I et al.	—	2022	→
Synthetic high-density lipoprotein nanoparticles delivering rapamycin for the treatment of age-related macular degeneration.	Mei L et al.	—	2022	→
Targeting senescent cells for vascular aging and related diseases.	Ding YN et al.	—	2022	→
The Implications of Bone Marrow Adipose Tissue on Inflammaging.	Aaron N et al.	—	2022	→
Theories and Molecular Basis of Vascular Aging: A Review of the Literature from VascAgeNet Group on Pathophysiological Mechanisms of Vascular Aging.	Gkaliagkousi E et al.	—	2022	→
Acer Truncatum Seed Oil Alleviates Learning and Memory Impairments of Aging Mice.	Li X et al.	—	2021	→
Activation of Autophagy Through the NLRP3/mTOR Pathway: A Potential Mechanism for Alleviation of Pneumonia by QingFei Yin.	Sun X et al.	—	2021	→
Acute TBK1/IKK-ε Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury.	Rehman R et al.	—	2021	→
ADAM10 Site-Dependent Biology: Keeping Control of a Pervasive Protease.	Tosetti F et al.	—	2021	→
Aging and age-related diseases: from mechanisms to therapeutic strategies.	Li Z et al.	—	2021	→
Anti-Inflammatory Properties of Diet: Role in Healthy Aging.	Stromsnes K et al.	—	2021	→
Bcl-2-dependent autophagy disruption during aging impairs amino acid utilization that is restored by hochuekkito.	Nahata M et al.	—	2021	→
Beneficial Effects of Exogenous Ketogenic Supplements on Aging Processes and Age-Related Neurodegenerative Diseases.	Kovács Z et al.	—	2021	→
Biomarker Identification in Membranous Nephropathy Using a Long Non-coding RNA-Mediated Competitive Endogenous RNA Network.	Zhou G et al.	—	2021	→
Cell Interplay in Osteoarthritis.	Li Z et al.	—	2021	→
Cell Senescence, DNA Damage, and Metabolism.	Shmulevich R et al.	—	2021	→
Cellular Senescence and Inflammaging in the Skin Microenvironment.	Lee YI et al.	—	2021	→
Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions.	Bazard P et al.	—	2021	→
Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging.	Wang Q et al.	—	2021	→
Effects of exercise on cellular and tissue aging.	Carapeto PV et al.	—	2021	→
Glioblastoma as an age-related neurological disorder in adults.	Kim M et al.	—	2021	→
Hallmarks of environmental insults.	Peters A et al.	—	2021	→
High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges.	Nikolaou C et al.	—	2021	→
Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation.	Zhang P et al.	—	2021	→
Hypothalamic gene transfer of BDNF promotes healthy aging.	Cao L et al.	—	2021	→
IL-6 regulates the bone metabolism and inflammatory microenvironment in aging mice by inhibiting Setd7.	Wang J et al.	—	2021	→
Impact of aging on gene expression response to x-ray irradiation using mouse blood.	Broustas CG et al.	—	2021	→
Inflammation, Nitro-Oxidative Stress, Impaired Autophagy, and Insulin Resistance as a Mechanistic Convergence Between Arterial Stiffness and Alzheimer's Disease.	Hendrickx JO et al.	—	2021	→
Ionizing Radiation-Induced Brain Cell Aging and the Potential Underlying Molecular Mechanisms.	Wang QQ et al.	—	2021	→
Kynurenine induces an age-related phenotype in bone marrow stromal cells.	Patel D et al.	—	2021	→
Lipoxin A4 promotes autophagy and inhibits overactivation of macrophage inflammasome activity induced by Pg LPS.	Zhao J et al.	—	2021	→
Mitochondrial quality control protects photoreceptors against oxidative stress in the H<sub>2</sub>O<sub>2</sub>-induced models of retinal degeneration diseases.	Zhou B et al.	—	2021	→
Modeling transcriptomic age using knowledge-primed artificial neural networks.	Holzscheck N et al.	—	2021	→
Neuroinflammation in Alzheimer's Disease.	Onyango IG et al.	—	2021	→
Neuroinflammation: Integrated Nervous Tissue Response through Intercellular Interactions at the "Whole System" Scale.	Nosi D et al.	—	2021	→
Role of Aberrantly Activated Lysophosphatidic Acid Receptor 1 Signaling Mediated Inflammation in Renal Aging.	Jin Y et al.	—	2021	→
Sarcopenia and perioperative management of elderly surgical patients.	Shi Y et al.	—	2021	→
Telomere Shortening and Psychiatric Disorders: A Systematic Review.	Pousa PA et al.	—	2021	→
The Alteration of Chloride Homeostasis/GABAergic Signaling in Brain Disorders: Could Oxidative Stress Play a Role?	Abruzzo PM et al.	—	2021	→
The associations of butyrate-producing bacteria of the gut microbiome with diet quality and muscle health.	Davis JA et al.	—	2021	→
The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice.	Yan X et al.	—	2021	→
The Impact of Ageing on the CNS Immune Response in Alzheimer's Disease.	Chee SEJ et al.	—	2021	→
The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage.	Sayed RKA et al.	—	2021	→
The potential role of mesenchymal stem cells in modulating antiageing process.	Govindasamy V et al.	—	2021	→
The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis.	Zheng L et al.	—	2021	→
The role of microglia in prion diseases and possible therapeutic targets: a literature review.	de Melo ASLF et al.	—	2021	→
The Subtle Role of Para-inflammation in Modulating the Progression of Dry Eye Disease.	Rolando M et al.	—	2021	→
Tumorigenic Aspects of MSC Senescence-Implication in Cancer Development and Therapy.	Mojsilović S et al.	—	2021	→
Warm, Sweetened Milk at the Twilight of Immunity - Alzheimer's Disease - Inflammaging, Insulin Resistance, <i>M. paratuberculosis</i> and Immunosenescence.	Dow CT	—	2021	→
Activation of immunosuppressive network in the aging process.	Salminen A	—	2020	→
Aging reduces succinate dehydrogenase activity in rat type IIx/IIb diaphragm muscle fibers.	Fogarty MJ et al.	—	2020	→
Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains.	De Biase D et al.	—	2020	→
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses.	Alsaleh G et al.	—	2020	→
Calorie Restriction and Aging in Humans.	Flanagan EW et al.	—	2020	→
Combined C-Reactive Protein and Novel Inflammatory Parameters as a Predictor in Cancer-What Can We Learn from the Hematological Experience?	Bruserud Ø et al.	—	2020	→
Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and PGC1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link.	Ryu JY et al.	—	2020	→
Effects of Interleukin-1β Inhibition on Incident Anemia: Exploratory Analyses From a Randomized Trial.	Vallurupalli M et al.	—	2020	→
Emerging molecular mediators and targets for age-related skeletal muscle atrophy.	Brown LA et al.	—	2020	→
Experimental Study Using Multiple Strains of Prion Disease in Cattle Reveals an Inverse Relationship between Incubation Time and Misfolded Prion Accumulation, Neuroinflammation, and Autophagy.	Mammadova N et al.	—	2020	→
First evidence for STING SNP R293Q being protective regarding obesity-associated cardiovascular disease in age-advanced subjects - a cohort study.	Hamann L et al.	—	2020	→
Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon.	Zambusi A et al.	—	2020	→
Impact of mesenchymal stem cell senescence on inflammaging.	Lee BC et al.	—	2020	→
Insights Into the Role of Mitochondrial Ion Channels in Inflammatory Response.	Ponnalagu D et al.	—	2020	→
Interplay between reactive oxygen species and autophagy in the course of age-related macular degeneration.	Nita M et al.	—	2020	→
Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration.	Kaarniranta K et al.	—	2020	→
Multi-omics network analysis reveals distinct stages in the human aging progression in epidermal tissue.	Holzscheck N et al.	—	2020	→
NLRP3 Inflammasome and Inflammatory Diseases.	Wang Z et al.	—	2020	→
NLRP inflammasomes and induced skin inflammation, barrier recovery and extended skin hydration.	Gruber JV et al.	—	2020	→
Possible Role of Mitochondrial DNA Mutations in Chronification of Inflammation: Focus on Atherosclerosis.	Orekhov AN et al.	—	2020	→
Sex hormone replacement therapy in periodontology-A systematic review.	Chaves JDP et al.	—	2020	→
Space-Dependent Glia-Neuron Interplay in the Hippocampus of Transgenic Models of β-Amyloid Deposition.	Lana D et al.	—	2020	→
Systemic long-term inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 ameliorates aging-induced changes in mice without affecting their life span.	Laitakari A et al.	—	2020	→
The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging".	Meftahi GH et al.	—	2020	→
Trans-10-hydroxy-2-decenoic acid protects against LPS-induced neuroinflammation through FOXO1-mediated activation of autophagy.	You M et al.	—	2020	→
Zebrafish <i>pten</i> Genes Play Relevant but Distinct Roles in Antiviral Immunity.	Pereiro P et al.	—	2020	→
Accelerated lung aging and chronic obstructive pulmonary disease.	Yoon YS et al.	—	2019	→
Age- and disease-specific changes of the kynurenine pathway in Parkinson's and Alzheimer's disease.	Sorgdrager FJH et al.	—	2019	→
Age-related schwannomatosis with potential exosome-mediated contribution to prostate hyperplasia: a case report and mini-review.	Chignon-Sicard B et al.	—	2019	→
[Aging of the immune system: From fundamental to clinical data].	Vallet H et al.	—	2019	→
An expanding GSK3 network: implications for aging research.	Souder DC et al.	—	2019	→
Autoinflammatory Disorders: A Review and Update on Pathogenesis and Treatment.	Havnaer A et al.	—	2019	→
Autophagy and Inflammasome Activation in Dilated Cardiomyopathy.	Caragnano A et al.	—	2019	→
COPD as a Disease of Immunosenescence.	Cho WK et al.	—	2019	→
Defective proteostasis in celiac disease as a new therapeutic target.	Maiuri L et al.	—	2019	→
Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy.	Fernandes R et al.	—	2019	→
Dicarbonyl Stress at the Crossroads of Healthy and Unhealthy Aging.	Nigro C et al.	—	2019	→
DNA damage responses in ageing.	da Silva PFL et al.	—	2019	→
Genistein antagonizes gliadin-induced CFTR malfunction in models of celiac disease.	Esposito S et al.	—	2019	→
Inflamm-Aging: A New Mechanism Affecting Premature Ovarian Insufficiency.	Huang Y et al.	—	2019	→
Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin.	Sayed RKA et al.	—	2019	→
lncRNA-Triggered Macrophage Inflammaging Deteriorates Age-Related Diseases.	Nie L et al.	—	2019	→
Loss of ferritin-positive microglia relates to increased iron, RNA oxidation, and dystrophic microglia in the brains of aged male marmosets.	Rodríguez-Callejas JD et al.	—	2019	→
Mesenchymal stem cell-macrophage crosstalk and bone healing.	Pajarinen J et al.	—	2019	→
Microglial distribution, branching, and clearance activity in aged rat hippocampus are affected by astrocyte meshwork integrity: evidence of a novel cell-cell interglial interaction.	Lana D et al.	—	2019	→
Molecular footprint of Medawar's mutation accumulation process in mammalian aging.	Turan ZG et al.	—	2019	→
Nutrient Sensing and Redox Balance: GCN2 as a New Integrator in Aging.	Falcón P et al.	—	2019	→
Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice.	Kakae M et al.	—	2019	→
Protective effects of autophagy against blue light-induced retinal degeneration in aged mice.	Xia H et al.	—	2019	→
Purple sweet potato color attenuated NLRP3 inflammasome by inducing autophagy to delay endothelial senescence.	Sun C et al.	—	2019	→
Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey.	Wang H et al.	—	2019	→
Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept.	Chung HY et al.	—	2019	→
Role of physical exercise in the regulation of epigenetic mechanisms in inflammation, cancer, neurodegenerative diseases, and aging process.	Ferioli M et al.	—	2019	→
Targeting Cell Senescence for the Treatment of Age-Related Bone Loss.	Pignolo RJ et al.	—	2019	→
The cannabinoid receptor 2 agonist, β-caryophyllene, improves working memory and reduces circulating levels of specific proinflammatory cytokines in aged male mice.	Lindsey LP et al.	—	2019	→
The Effects of Acute and Chronic Aerobic Activity on the Signaling Pathway of the Inflammasome NLRP3 Complex in Young Men.	Khakroo Abkenar I et al.	—	2019	→
The <i>vivo</i> antioxidant activity of self-made aged garlic extract on the d-galactose-induced mice and its mechanism research <i>via</i> gene chip analysis.	Wang X et al.	—	2019	→
The Link Between Inflammaging and Degenerative Joint Diseases.	Rezuș E et al.	—	2019	→
The Relation of Inflammaging With Skeletal Muscle Properties in Elderly Men.	Zembron-Lacny A et al.	—	2019	→
The Signaling of Cellular Senescence in Diabetic Nephropathy.	Xiong Y et al.	—	2019	→
TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson's diseases in vivo model.	Campolo M et al.	—	2019	→
Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook.	Scarnati MS et al.	—	2019	→
Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis.	Calabrese V et al.	—	2018	→
Aging Hallmarks: The Benefits of Physical Exercise.	Rebelo-Marques A et al.	—	2018	→
Aging, inflammation and the environment.	Bektas A et al.	—	2018	→
Ayurveda and the science of aging.	Rao RV	—	2018	→
Bat Biology, Genomes, and the Bat1K Project: To Generate Chromosome-Level Genomes for All Living Bat Species.	Teeling EC et al.	—	2018	→
Beyond ROS clearance: Peroxiredoxins in stress signaling and aging.	Detienne G et al.	—	2018	→
Bone Marrow Fat and Hematopoiesis.	Wang H et al.	—	2018	→
GIT2-A keystone in ageing and age-related disease.	van Gastel J et al.	—	2018	→
GRK5 - A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders.	Hendrickx JO et al.	—	2018	→
Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.	Yen K et al.	—	2018	→
Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer's Disease.	Mishra A et al.	—	2018	→
Macrophages in the Aging Liver and Age-Related Liver Disease.	Stahl EC et al.	—	2018	→
Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases.	Dela Cruz CS et al.	—	2018	→
Mitochondrial quality control in AMD: does mitophagy play a pivotal role?	Hyttinen JMT et al.	—	2018	→
Nutrition and Ageing.	Malcomson FC et al.	—	2018	→
Protective Role of Autophagy in Nlrp3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries.	Yuan X et al.	—	2018	→
Reactive Oxygen Species: the Dual Role in Physiological and Pathological Conditions of the Human Body.	Bardaweel SK et al.	—	2018	→
Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis.	Vinatier C et al.	—	2018	→
Searching for Clinically Relevant Biomarkers in Geriatric Oncology.	Katsila T et al.	—	2018	→
Telomeres, Telomerase and Ageing.	Saretzki G	—	2018	→
The association between obstructive sleep apnea and shortened telomere length: a systematic review and meta-analysis.	Huang P et al.	—	2018	→
The biological age linked to oxidative stress modifies breast cancer aggressiveness.	Sáez-Freire MDM et al.	—	2018	→
The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia.	Lai M et al.	—	2018	→
The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes.	Sayed RKA et al.	—	2018	→
The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process.	Salminen A et al.	—	2018	→
Understanding How Dogs Age: Longitudinal Analysis of Markers of Inflammation, Immune Function, and Oxidative Stress.	Alexander JE et al.	—	2018	→
Aging and immortality in unicellular species.	Florea M	—	2017	→
Alterations in the Interplay between Neurons, Astrocytes and Microglia in the Rat Dentate Gyrus in Experimental Models of Neurodegeneration.	Lana D et al.	—	2017	→
A reverse genetics cell-based evaluation of genes linked to healthy human tissue age.	Crossland H et al.	—	2017	→
Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88.	Into T et al.	—	2017	→
Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes.	Rhinn H et al.	—	2017	→
Endogenous Stem Cells in Homeostasis and Aging.	Lim JE et al.	—	2017	→
Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition.	Kim SH et al.	—	2017	→
Functional relevance of miRNAs in premature ageing.	Caravia XM et al.	—	2017	→
Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects.	Mejías-Peña Y et al.	—	2017	→
Inflammation and premature aging in advanced chronic kidney disease.	Kooman JP et al.	—	2017	→
Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs).	Kinnunen K et al.	—	2017	→
Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?	Korolchuk VI et al.	—	2017	→
Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System.	Bollaerts I et al.	—	2017	→
NF-κB Immunity in the Brain Determines Fly Lifespan in Healthy Aging and Age-Related Neurodegeneration.	Kounatidis I et al.	—	2017	→
Promising Links between Meditation and Reduced (Brain) Aging: An Attempt to Bridge Some Gaps between the Alleged Fountain of Youth and the Youth of the Field.	Kurth F et al.	—	2017	→
Small molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.	Zhao Y et al.	—	2017	→
The association between post-traumatic stress disorder and shorter telomere length: A systematic review and meta-analysis.	Li X et al.	—	2017	→
The role of metabolism in the pathogenesis of osteoarthritis.	Mobasheri A et al.	—	2017	→
Triggering of inflammasome by impaired autophagy in response to acute experimental Parkinson's disease: involvement of the PI3K/Akt/mTOR pathway.	Giacoppo S et al.	—	2017	→
VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy.	Papadopoulos C et al.	—	2017	→
Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis.	Berridge MJ	—	2017	→
'Adipaging': ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue.	Pérez LM et al.	—	2016	→
Ageing and the telomere connection: An intimate relationship with inflammation.	Zhang J et al.	—	2016	→
An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment.	Xia S et al.	—	2016	→
A Systematic Investigation into Aging Related Genes in Brain and Their Relationship with Alzheimer's Disease.	Meng G et al.	—	2016	→
Autophagy: a new target for nonalcoholic fatty liver disease therapy.	Mao Y et al.	—	2016	→
Autophagy in osteoarthritis.	Li YS et al.	—	2016	→
Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation.	Ribeiro M et al.	—	2016	→
Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells.	De Filippis L et al.	—	2016	→
Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells.	Carrero D et al.	—	2016	→
Impaired mitochondrial degradation by autophagy in the skeletal muscle of the aged female interleukin 10 null mouse.	Ko F et al.	—	2016	→
Innate immunity in diabetes and diabetic nephropathy.	Wada J et al.	—	2016	→
Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages.	Aflaki E et al.	—	2016	→
Mediterranean nutraceutical foods: Strategy to improve vascular ageing.	Accardi G et al.	—	2016	→
Mouse <i>Tmem135</i> mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies.	Lee WH et al.	—	2016	→
RNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney.	Park D et al.	—	2016	→
Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.	Volt H et al.	—	2016	→
Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females.	Ribas V et al.	—	2016	→
The aging population: demographics and the biology of aging.	Kanasi E et al.	—	2016	→
The ins and outs of muscle stem cell aging.	Brack AS et al.	—	2016	→
The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus.	Kim SJ et al.	—	2016	→
The neuron-astrocyte-microglia triad involvement in neuroinflammaging mechanisms in the CA3 hippocampus of memory-impaired aged rats.	Lana D et al.	—	2016	→
The role of hydrogen sulfide in aging and age-related pathologies.	Perridon BW et al.	—	2016	→
Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing.	Ahn M et al.	—	2016	→
β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation.	Bae HR et al.	—	2016	→
Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a.	Smith EJ et al.	—	2015	→
Aging without Apolipoprotein D: Molecular and cellular modifications in the hippocampus and cortex.	Sanchez D et al.	—	2015	→
Anti-inflammatory effect of resveratrol in old mice liver.	Tung BT et al.	—	2015	→
Autophagy Controls Acquisition of Aging Features in Macrophages.	Stranks AJ et al.	—	2015	→
B cells modulate systemic responses to Pneumocystis murina lung infection and protect on-demand hematopoiesis via T cell-independent innate mechanisms when type I interferon signaling is absent.	Hoyt TR et al.	—	2015	→
Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis.	Musumeci G et al.	—	2015	→
Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults.	Tyrrell DJ et al.	—	2015	→
Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis.	Mobasheri A et al.	—	2015	→
Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes.	Prattichizzo F et al.	—	2015	→
Essential role for autophagy in life span extension.	Madeo F et al.	—	2015	→
Exercise attenuates the major hallmarks of aging.	Garatachea N et al.	—	2015	→
Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age.	Wu X et al.	—	2015	→
Impact of the circadian clock on the aging process.	Fonseca Costa SS et al.	—	2015	→
Increased expression of IL-18 in the serum and islets of type 1 diabetics.	Harms RZ et al.	—	2015	→
Influence of non-steroidal anti-inflammatory drugs on Drosophila melanogaster longevity.	Danilov A et al.	—	2015	→
Inhibition of B Lymphopoiesis by Adipocytes and IL-1-Producing Myeloid-Derived Suppressor Cells.	Kennedy DE et al.	—	2015	→
Innate immune perturbations, accumulating DAMPs and inflammasome dysregulation: A ticking time bomb in ageing.	Kapetanovic R et al.	—	2015	→
Lipid-Laden Multilocular Cells in the Aging Thymus Are Phenotypically Heterogeneous.	Langhi LG et al.	—	2015	→
NLR family pyrin domain containing 3 (NLRP3) inflammasome gene polymorphism rs7512998 (C>T) predicts aging-related increase of blood pressure, the TAMRISK study.	Kunnas T et al.	—	2015	→
Old, new and emerging functions of caspases.	Shalini S et al.	—	2015	→
Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent.	Sabbieti MG et al.	—	2015	→
Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic stem cells in aged C57BL/6 J mice.	Porto ML et al.	—	2015	→
SIRT1: role in cardiovascular biology.	Ma L et al.	—	2015	→
The role of autophagy in vascular biology.	Nussenzweig SC et al.	—	2015	→
The zebrafish as a gerontology model in nervous system aging, disease, and repair.	Van Houcke J et al.	—	2015	→
Ageing and the border between health and disease.	MacNee W et al.	—	2014	→
Ageing gender-specific "Biomarkers of Homeostasis", to protect ourselves against the diseases of the old age.	Berghella AM et al.	—	2014	→
Amelioration of mitochondrial dysfunction-induced insulin resistance in differentiated 3T3-L1 adipocytes via inhibition of NF-κB pathways.	Bakar MH et al.	—	2014	→
An update on autoinflammatory diseases.	Ciccarelli F et al.	—	2014	→
Can enhanced autophagy be associated with human longevity? Serum levels of the autophagy biomarker beclin-1 are increased in healthy centenarians.	Emanuele E et al.	—	2014	→
Chronic kidney disease and premature ageing.	Kooman JP et al.	—	2014	→
Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging.	Grammatikakis I et al.	—	2014	→
Loss of TRPML1 promotes production of reactive oxygen species: is oxidative damage a factor in mucolipidosis type IV?	Coblentz J et al.	—	2014	→
Natural compounds and aging: between autophagy and inflammasome.	Chuang SY et al.	—	2014	→
Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review.	Salminen LE et al.	—	2014	→
Purple sweet potato color ameliorates kidney damage via inhibiting oxidative stress mediated NLRP3 inflammasome activation in high fat diet mice.	Shan Q et al.	—	2014	→
Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats.	Zhang QY et al.	—	2014	→
Surveillance, phagocytosis, and inflammation: how never-resting microglia influence adult hippocampal neurogenesis.	Sierra A et al.	—	2014	→
The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach.	Calçada D et al.	—	2014	→
Age-dependent dysregulation of innate immunity.	Shaw AC et al.	—	2013	→
Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration.	Kaarniranta K et al.	—	2013	→
Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury.	Maejima I et al.	—	2013	→
Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process.	Salminen A et al.	—	2013	→
Blood CD33(+)HLA-DR(-) myeloid-derived suppressor cells are increased with age and a history of cancer.	Verschoor CP et al.	—	2013	→
Cellular and molecular mechanisms of age-related macular degeneration: from impaired autophagy to neovascularization.	Klettner A et al.	—	2013	→
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process.	Salminen A et al.	—	2013	→
Immunosuppressants in cancer prevention and therapy.	Blagosklonny MV	—	2013	→
Is immunesenescence a contributing factor for periodontal diseases?	Rajendran M et al.	—	2013	→
MicroRNAs linking inflamm-aging, cellular senescence and cancer.	Olivieri F et al.	—	2013	→
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials.	Marzetti E et al.	—	2013	→
M(o)TOR of aging: MTOR as a universal molecular hypothalamus.	Blagosklonny MV	—	2013	→
NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies.	Balistreri CR et al.	—	2013	→
p53 regulates the transcription of the anti-inflammatory molecule developmental endothelial locus-1 (Del-1).	Kim H et al.	—	2013	→
Rat retinal transcriptome: effects of aging and AMD-like retinopathy.	Kozhevnikova OS et al.	—	2013	→
Selective anti-cancer agents as anti-aging drugs.	Blagosklonny MV	—	2013	→
The hallmarks of aging.	López-Otín C et al.	—	2013	→
TIPE2 deficiency accelerates neointima formation by downregulating smooth muscle cell differentiation.	Zhang G et al.	—	2013	→
TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.	Blagosklonny MV	—	2013	→
Type 2 diabetes mellitus: a metabolic autoinflammatory disease.	Mandrup-Poulsen T	—	2013	→
Understanding how we age: insights into inflammaging.	Baylis D et al.	—	2013	→
β-Cell inflammation in human type 2 diabetes and the role of autophagy.	Marselli L et al.	—	2013	→
Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process.	Salminen A et al.	—	2012	→
IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'bystander senescence'.	Hubackova S et al.	—	2012	→
Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion.	Choi YJ et al.	—	2012	→
Management of anemia of inflammation in the elderly.	Macciò A et al.	—	2012	→
Reactive oxygen species in health and disease.	Alfadda AA et al.	—	2012	→