Thioredoxin-interacting protein links oxidative stress to inflammasome activation.
paper
Cited
Public
Unavailable
- Authors
- Zhou, Rongbin; Tardivel, Aubry; Thorens, Bernard; Choi, Inpyo; Tschopp, JΓΌrg
- Year
- 2010
- Journal
- Nature immunology
- PMID
- 20023662
- DOI
- 10.1038/ni.1831
The NLRP3 inflammasome has a major role in regulating innate immunity. Deregulated inflammasome activity is associated with several inflammatory diseases, yet little is known about the signaling pathways that lead to its activation. Here we show that NLRP3 interacted with thioredoxin (TRX)-interacting protein (TXNIP), a protein linked to insulin resistance. Inflammasome activators such as uric acid crystals induced the dissociation of TXNIP from thioredoxin in a reactive oxygen species (ROS)-sensitive manner and allowed it to bind NLRP3. TXNIP deficiency impaired activation of the NLRP3 inflammasome and subsequent secretion of interleukin 1beta (IL-1beta). Akin to Txnip(-/-) mice, Nlrp3(-/-) mice showed improved glucose tolerance and insulin sensitivity. The participation of TXNIP in the NLRP3 inflammasome activation may provide a mechanistic link to the observed involvement of IL-1beta in the pathogenesis of type 2 diabetes.
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| Tanshinone IIA suppresses endoplasmic reticulum stress-mediated IRE1Ξ±/TXNIP/NLRP3 pathway to mitigate pyroptosis in type 2 diabetic osteoporosis. | Jiang Z et al. | β | 2025 | β |
| Target Discovery to Diabetes Therapy-TXNIP From Bench to Bedside With NIDDK. | Shalev A | β | 2025 | β |
| Targeting neurodegeneration and inflammation with thioredoxin-mimetic peptides. | Atlas D | β | 2025 | β |
| Targeting NLRP3 inflammasome with curcumin: mechanisms and therapeutic promise in chronic inflammation. | Pandey SN et al. | β | 2025 | β |
| Targeting oxidative stress-mediated regulated cell death as a vulnerability in cancer. | Chen D et al. | β | 2025 | β |
| Targeting pyroptosis: A novel strategy of ginseng for the treatment of diabetes and its chronic complications. | Li K et al. | β | 2025 | β |
| Targeting the NLRP3 inflammasome-IL-1Ξ² pathway in type 2 diabetes and obesity. | Meier DT et al. | β | 2025 | β |
| Targeting TXNIP With Saroglitazar Mitigates Acute Hepatic Injury in Rats Challenged With Thioacetamide: A Multistep Computational and Experimental Approach. | Elnaghy F et al. | β | 2025 | β |
| Targeting Ubiquitin-Proteasome system (UPS) in treating osteoarthritis. | Wong PF et al. | β | 2025 | β |
| Tetrandrine improves oxidative stress and pyroptosis of podocytes in diabetic kidney disease by regulating TXNIP/NLRP3/GSDMD signaling pathway. | Tang L et al. | β | 2025 | β |
| The endoplasmic reticulum-mitochondrial crosstalk involved in nanoplastics and di(2-ethylhexyl) phthalate co-exposure induced the damage to mouse mammary epithelial cells. | Wang C et al. | β | 2025 | β |
| The Impact of Liraglutide, a GLP-1 Receptor Agonist, on High Glucose-Induced Inflammation, Apoptosis, Oxidative Stress, and NLRP3 Signaling. | Gokce M et al. | β | 2025 | β |
| The Interplay Between Oxidative Stress and Lipid Composition in Obesity-Induced Inflammation: Antioxidants as Therapeutic Agents in Metabolic Diseases. | Olivares-Vicente M et al. | β | 2025 | β |
| The potential mitigating effect of febuxostat alone or with donepezil on scopolamine-induced Alzheimer's disease in rats: The role of TXNIP/NLRP3 inflammasome signaling pathway. | Taha DE et al. | β | 2025 | β |
| The Potential of Nanotechnology in Anti-cancer Drug to Regulate Nrf2 Signaling for Cancer Therapeutic Purposes. | Yari A et al. | β | 2025 | β |
| The Protective Efficacy of Total Alkaloids from Nelumbinis Plumula on Irradiation-Induced Oxidative Stress Damage in Human Umbilical Vein Endothelial Cells. | Bu J et al. | β | 2025 | β |
| Therapeutic approaches for liver fibrosis/cirrhosis by targeting pyroptosis. | Qiao G et al. | β | 2025 | β |
| The relationship between neurodevelopmental disorders (NDDs) and NLRP3 inflammasome. | Shahi A et al. | β | 2025 | β |
| The Role of Insulin Resistance in Cardiorenal Metabolic Syndrome. | Xiao J et al. | β | 2025 | β |
| The Role of Mitochondrial Energy Metabolism in the Mechanism of Exercise Improving Depression. | Liu Y et al. | β | 2025 | β |
| The Role of Reactive Oxygen Species (ROS) in Periodontitis: A Potential Therapeutic Target. | Yang S et al. | β | 2025 | β |
| The TXNIP-mTOR-Autophagy axis in diabetic kidney disease: mechanistic insights and therapeutic implications. | Zhu Q et al. | β | 2025 | β |
| The Ubiquitin-Proteasome System in Brain Disorders: Pathogenic Pathways, Post-Translational Tweaks, and Therapeutic Frontiers. | Gupta R et al. | β | 2025 | β |
| Thioredoxin-Interacting Protein (TXNIP) in Gestational Diabetes Mellitus. | Kokkinopoulou I et al. | β | 2025 | β |
| Topical Instillation of N-Acetylcysteine and N-Acetylcysteine Amide Impedes Age-Related Lens Opacity in Mice. | Ishida H et al. | β | 2025 | β |
| Transcriptional regulation of Rankl by Txnip-Ecd in aging and diabetic related osteoporosis. | Cao X et al. | β | 2025 | β |
| Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health. | Caradonna E et al. | β | 2025 | β |
| TXM-CB13 Improves the Intestinal Mucosal Barrier and Alleviates Colitis by Inhibiting the ROS/TXNIP/TRX/NLRP3 and TLR4/MyD88/NF-ΞΊB/NLRP3 Pathways. | Cao R et al. | β | 2025 | β |
| Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice. | Zou M et al. | β | 2025 | β |
| TXNIP in cancer: Unlocking biological insights and tackling clinical challenges. | Del Console P et al. | β | 2025 | β |
| TXNIP knockdown ameliorates hepatic ischemia/reperfusion injury by inhibiting apoptosis and improving mitochondrial dysfunction via HIF-1Ξ±. | Zhang Y et al. | β | 2025 | β |
| TXNIP mediates ferroptosis in a bronchopulmonary dysplasia mouse model by regulating the SLC7A11/GPX4 pathway. | Chen D et al. | β | 2025 | β |
| TXNIP promotes viral replication by disrupting MAVS-mediated antiviral signaling and serves as a therapeutic target for antiviral therapy. | Chen R et al. | β | 2025 | β |
| TXNIP Suppresses Lung Cancer Progression by Inhibiting TRAF6-Mediated NF-ΞΊB Activation and Autophagy. | Kim JY et al. | β | 2025 | β |
| UCP2 inhibition exaggerates diabetic cardiomyopathy by facilitating the activation of NLRP3 and pyroptosis. | Zhang L et al. | β | 2025 | β |
| Unraveling the ROS-Inflammation-Immune Balance: A New Perspective on Aging and Disease. | Fang S et al. | β | 2025 | β |
| Unveiling the therapeutic benefits of black chokeberry (<i>Aronia melanocarpa</i>) in alleviating hyperuricemia in mice. | Liu CY et al. | β | 2025 | β |
| Updated insights into the molecular networks for NLRP3 inflammasome activation. | Paik S et al. | β | 2025 | β |
| Verapamil inhibits TXNIP-dependent NLRP3 Inflammasome activation in an ulcerative colitis rat model: A new evolving role of the calcium channel blocker. | Shawky A et al. | β | 2025 | β |
| Ξ±-Tocopherol Ameliorates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation by Promoting Nrf2 Nuclear Translocation. | Fang R et al. | β | 2025 | β |
| 5'AMP-activated protein kinase: an emerging target of phytochemicals to treat chronic inflammatory diseases. | Abdul Khaliq H et al. | β | 2024 | β |
| Activation of the ROS/TXNIP/NLRP3 pathway disrupts insulin-dependent glucose uptake in skeletal muscle of insulin-resistant obese mice. | Russell-GuzmΓ‘n J et al. | β | 2024 | β |
| Albumin-fused thioredoxin ameliorates high-fat diet-induced non-alcoholic steatohepatitis. | Murata R et al. | β | 2024 | β |
| Ameliorative action of "daitongxiao" against hyperuricemia includes the "uric acid transporter group". | Zheng L et al. | β | 2024 | β |
| Ameliorative impacts of Sinapic acid against monosodium urate crystal-induced gouty arthritis and inflammation through different signaling pathways. | Ishaq M et al. | β | 2024 | β |
| Aminoadipic acid aggravates atherosclerotic vascular inflammation through ROS/TXNIP/NLRP3 pathway, a harmful microbial metabolite reduced by paeonol. | Wang T et al. | β | 2024 | β |
| Analysis of prognostic biomarker models of TXNIP/NLRP3/IL1B inflammasome pathway in patients with acute myeloid leukemia. | Chen J et al. | β | 2024 | β |
| A Review of Medicinal Plants and Phytochemicals for the Management of Gout. | Frazaei MH et al. | β | 2024 | β |
| Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy. | Hu Z et al. | β | 2024 | β |
| Astragalus polysaccharides ameliorate osteoarthritis via inhibiting apoptosis by regulating ROS-mediated ASK1/p38 MAPK signaling pathway targeting on TXN. | Xu J et al. | β | 2024 | β |
| Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner. | Wang Y et al. | β | 2024 | β |
| Beyond insulin: Unraveling the complex interplay of ER stress, oxidative damage, and CFTR modulation in CFRD. | Umashankar B et al. | β | 2024 | β |
| Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes. | Qi B et al. | β | 2024 | β |
| Bone marrow mesenchymal stem cells-derived exosomes promote spinal cord injury repair through the miR-497-5p/TXNIP/NLRP3 axis. | Xu J et al. | β | 2024 | β |
| Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy. | Zhong H et al. | β | 2024 | β |
| Cardioprotective properties of OMT-28, a synthetic analog of omega-3 epoxyeicosanoids. | Kranrod J et al. | β | 2024 | β |
| ChREBP plays a pivotal role in the nutrient-mediated regulation of metabolic gene expression in brown adipose tissue. | Baek S et al. | β | 2024 | β |
| Color-Flu Fluorescent Reporter Influenza A Viruses Allow for In Vivo Studies of Innate Immune Function in Zebrafish. | Soos BL et al. | β | 2024 | β |
| Combination therapy enhances efficacy and overcomes toxicity of metal-based anti-diabetic agent. | Shang B et al. | β | 2024 | β |
| Comparative interactome analysis of Ξ±-arrestin families in human and <i>Drosophila</i>. | Lee KT et al. | β | 2024 | β |
| Copper oxide nanoparticles exacerbate chronic obstructive pulmonary disease by activating the TXNIP-NLRP3 signaling pathway. | Kim WI et al. | β | 2024 | β |
| Correlation between abnormal cellular immune and changes of magnetic resonance spectroscopy in patients with Alzheimer's disease. | Zeng H et al. | β | 2024 | β |
| Co-Treatment with Phlorotannin and Extracellular Vesicles from <i>Ecklonia cava</i> Inhibits UV-Induced Melanogenesis. | Byun KA et al. | β | 2024 | β |
| Crosstalk between Nrf2 signaling pathway and inflammation in ischemic stroke: Mechanisms of action and therapeutic implications. | Khassafi N et al. | β | 2024 | β |
| Crosstalk between Oxidative Stress and Inflammation Caused by Noise and Air Pollution-Implications for Neurodegenerative Diseases. | KuntiΔ M et al. | β | 2024 | β |
| Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy. | KejΓk Z et al. | β | 2024 | β |
| Cyclin-dependent kinase inhibitor 1A inhibits pyroptosis to enhance human lung adenocarcinoma cell radioresistance by promoting DNA repair. | Li J et al. | β | 2024 | β |
| Decreased expression of <i>TXNIP</i> is associated with poor prognosis and immune infiltration in kidney renal clear cell carcinoma. | Liu W et al. | β | 2024 | β |
| Diabetes, Diabetic Retinopathy, and Inflammatory Disorders. | Sheemar A et al. | β | 2024 | β |
| Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease. | Zha Z et al. | β | 2024 | β |
| Exocarpium Citri Grandis ameliorates LPS-induced acute lung injury by suppressing inflammation, NLRP3 inflammasome, and ferroptosis. | Xu Z et al. | β | 2024 | β |
| Exosomal OIP5-AS1 attenuates cerebral ischemia-reperfusion injury by negatively regulating TXNIP protein stability and inhibiting neuronal pyroptosis. | Li Z et al. | β | 2024 | β |
| Exploring the correlation between innate immune activation of inflammasome and regulation of pyroptosis after intracerebral hemorrhage: From mechanism to treatment. | Jin Z et al. | β | 2024 | β |
| Exploring the role of NLRP3 infalmmasome in diabetes: a literature review and bibliometric analysis. | Tan Y et al. | β | 2024 | β |
| Exploring the role of purinergic receptor P2RY1 in type 2 diabetes risk and pathophysiology: Insights from human functional genomics. | Dance A et al. | β | 2024 | β |
| Ezetimibe ameliorates cisplatin-induced nephrotoxicity: A novel therapeutic approach via modulating AMPK/Nrf2/TXNIP signaling. | Fathy N et al. | β | 2024 | β |
| Fantastic voyage: The journey of NLRP3 inflammasome activation. | Que X et al. | β | 2024 | β |
| FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation. | Xu J et al. | β | 2024 | β |
| Forever chemicals don't make hero mutant ninja turtles: Elevated PFAS levels linked to unusual scute development in newly emerged freshwater turtle hatchlings (Emydura macquarii macquarii) and a reduction in turtle populations. | Beale DJ et al. | β | 2024 | β |
| FoxO6-Mediated TXNIP Induces Lipid Accumulation in the Liver through NLRP3 Inflammasome Activation. | Kim ME et al. | β | 2024 | β |
| From inflammatory signaling to neuronal damage: Exploring NLR inflammasomes in ageing neurological disorders. | Zhang J et al. | β | 2024 | β |
| FTO Deficiency Alleviates LPS-induced Acute Lung Injury by TXNIP/NLRP3-mediated Alveolar Epithelial Cell Pyroptosis. | Xie WM et al. | β | 2024 | β |
| Gamma-aminobutyric acid enhances miR-21-5p loading into adipose-derived stem cell extracellular vesicles to alleviate myocardial ischemia-reperfusion injury <i>via</i> TXNIP regulation. | Wang FD et al. | β | 2024 | β |
| Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis. | Jia L et al. | β | 2024 | β |
| Glucose fluctuations aggravate cardiomyocyte apoptosis by enhancing the interaction between Txnip and Akt. | Zhang ZY et al. | β | 2024 | β |
| Gut microbiota interventions in type 2 diabetes mellitus: An umbrella review of glycemic indices. | Keivanlou MH et al. | β | 2024 | β |
| Gypenoside XLIX alleviates intestinal injury by inhibiting sepsis-induced inflammation, oxidative stress, apoptosis, and autophagy. | Ping K et al. | β | 2024 | β |
| Heterogeneity of <i>Salmonella enterica</i> lipopolysaccharide counteracts macrophage and antimicrobial peptide defenses. | Heffernan LM et al. | β | 2024 | β |
| Hydrogen Attenuates Cognitive Impairment in Rat Models of Vascular Dementia by Inhibiting Oxidative Stress and NLRP3 Inflammasome Activation. | Yang C et al. | β | 2024 | β |
| Identification of a covalent NEK7 inhibitor to alleviate NLRP3 inflammasome-driven metainflammation. | Jin X et al. | β | 2024 | β |
| Impact of fasting & ketogenic interventions on the NLRP3 inflammasome: A narrative review. | Neudorf H et al. | β | 2024 | β |
| Inducers and Inhibitors of Pyroptotic Death of Granulosa Cells in Models of Premature Ovarian Insufficiency and Polycystic Ovary Syndrome. | Berkel C | β | 2024 | β |
| Inflammasome activation in response to aberrations of cellular homeostasis in epithelial cells from human cornea and retina. | Korhonen E | β | 2024 | β |
| Inhibition of calpain reduces oxidative stress and attenuates pyroptosis and ferroptosis in Clostridium perfringens Beta-1 toxin-induced macrophages. | Zhang S et al. | β | 2024 | β |
| Inhibition of IRE1Ξ±/XBP1 axis alleviates LPS-induced acute lung injury by suppressing TXNIP/NLRP3 inflammasome activation and ERK/p65 signaling pathway. | Wang S et al. | β | 2024 | β |
| Inhibition of NLRP3 inflammasome-A potential mechanistic therapeutic for treatment of polycystic ovary syndrome? | Chamanara S et al. | β | 2024 | β |
| Inhibitors of NLRP3 Inflammasome Formation: A Cardioprotective Role for the Gasotransmitters Carbon Monoxide, Nitric Oxide, and Hydrogen Sulphide in Acute Myocardial Infarction. | Payne FM et al. | β | 2024 | β |
| Intestinal metabolite UroB alleviates cerebral ischemia/reperfusion injury by promoting competition between TRIM65 and TXNIP for binding to NLRP3 inflammasome in response to neuroinflammation. | Luo J et al. | β | 2024 | β |
| Intracellular acidification and glycolysis modulate inflammatory pathway in senescent cells. | Kawakami S et al. | β | 2024 | β |
| Investigating the effect of verapamil on preservation of beta-cell function in adults with newly diagnosed type 1 diabetes mellitus (Ver-A-T1D): protocol for a randomised, double-blind, placebo-controlled, parallel-group, multicentre trial. | Wych J et al. | β | 2024 | β |
| LncRNA/CircRNA-miRNA-mRNA Axis in Atherosclerotic Inflammation: Research Progress. | Lv N et al. | β | 2024 | β |
| Long-chain fatty acids - The turning point between 'mild' and 'severe' acute pancreatitis. | Liu Q et al. | β | 2024 | β |
| Luteolin, apigenin, and chrysin inhibit lipotoxicity-induced NLRP3 inflammasome activation and autophagy damage in macrophages by suppressing endoplasmic reticulum stress. | Lo CW et al. | β | 2024 | β |
| Magnesium hydride protects against acetaminophen-induced acute kidney injury by inhibiting TXNIP/NLRP3/nf-ΞΊb pathway. | Si Y et al. | β | 2024 | β |
| Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer's disease. | Jha D et al. | β | 2024 | β |
| Metabolite-derived damage-associated molecular patterns in immunological diseases. | Kang N et al. | β | 2024 | β |
| Metabolomic Profiling and In Vivo Antiepileptic Effect of <i>Zygophyllum album</i> Aerial Parts and Roots Crude Extracts against Pentylenetetrazole-Induced Kindling in Mice. | Abdel-Hamed AR et al. | β | 2024 | β |
| METTL14 drives growth and metastasis of non-small cell lung cancer by regulating pri-miR-93-5p maturation and TXNIP expression. | Qian S et al. | β | 2024 | β |
| METTL3 Modulates TXNIP Expression to Affect the Activation of NLRP3 Inflammasome in Hepatic Cells Under Oxygen-Glucose Deprivation/Reperfusion Injury. | Zhang Y et al. | β | 2024 | β |
| Microglia-induced neuroinflammation in hippocampal neurogenesis following traumatic brain injury. | Navabi SP et al. | β | 2024 | β |
| MicroRNA Regulation for Inflammasomes in High Glucose-Treated ARPE-19 Cells. | Kim JH et al. | β | 2024 | β |
| Mitochondrial damage and clearance in retinal pigment epithelial cells. | Gurubaran IS | β | 2024 | β |
| Mitochondrial dysfunction and NLRP3 inflammasome: key players in kidney stone formation. | Su B et al. | β | 2024 | β |
| Mitochondrial dysfunction in sepsis: mechanisms and therapeutic perspectives. | Hu D et al. | β | 2024 | β |
| Modified 5-aminolevulinic acid photodynamic therapy induces cutaneous squamous cell carcinoma cell pyroptosis via the JNK signaling pathway. | Chen D et al. | β | 2024 | β |
| Molecular Activation of NLRP3 Inflammasome by Particles and Crystals: A Continuing Challenge of Immunology and Toxicology. | Ma Q et al. | β | 2024 | β |
| Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammationβmediating treatment options (Review). | Varra FN et al. | β | 2024 | β |
| Molecular Mechanisms in Pathophysiology of Mucopolysaccharidosis and Prospects for Innovative Therapy. | Ago Y et al. | β | 2024 | β |
| Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis. | Lemche E et al. | β | 2024 | β |
| Molecular Regulation of Transforming Growth Factor-Ξ²1-induced Thioredoxin-interacting Protein Ubiquitination and Proteasomal Degradation in Lung Fibroblasts: Implication in Pulmonary Fibrosis. | Taleb SJ et al. | β | 2024 | β |
| Multitarget Effects of Nrf2 Signalling in the Brain: Common and Specific Functions in Different Cell Types. | Navarro E et al. | β | 2024 | β |
| NADPH oxidase 4 in mouse Ξ² cells participates in inflammation on chronic nutrient overload. | HolendovΓ‘ B et al. | β | 2024 | β |
| Nanomaterials Enhance Pyroptosis-Based Tumor Immunotherapy. | Ji F et al. | β | 2024 | β |
| Nanoβselenium alleviates the pyroptosis of cardiovascular endothelial cells in chicken induced by decabromodiphenyl ether through ERS-TXNIP-NLRP3 pathway. | Jiang Y et al. | β | 2024 | β |
| Narirutin Attenuates Cerebral Ischemia-Reperfusion Injury by Suppressing the TXNIP/NLRP3 Pathway. | Luo L et al. | β | 2024 | β |
| NCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillance. | Li L et al. | β | 2024 | β |
| NEMO-Binding Domain/IKKΞ³ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase-Induced Lysosome Membrane Permeabilization. | Geng Y et al. | β | 2024 | β |
| Neuroinflammation in Age-Related Neurodegenerative Diseases: Role of Mitochondrial Oxidative Stress. | Abadin X et al. | β | 2024 | β |
| New horizon of the combined BCG vaccine with probiotic and liraglutide in augmenting beta cell survival <i>via</i> suppression of TXNIP/NLRP3 pyroptosis signaling in Streptozocin-Induced diabetes mellitestype-1 in rats. | Khalifa AK et al. | β | 2024 | β |
| New insights into the interplay between autophagy, gut microbiota and insulin resistance in metabolic syndrome. | Zhao J et al. | β | 2024 | β |
| New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation. | Kodi T et al. | β | 2024 | β |
| NLRP3 and autophagy in retinal ganglion cell inflammation in age-related macular degeneration: potential therapeutic implications. | Wang XL et al. | β | 2024 | β |
| NLRP3 Inflammasome: A central player in renal pathologies and nephropathy. | Henedak NT et al. | β | 2024 | β |
| NLRP3 inflammasome and pyroptosis in cardiovascular diseases and exercise intervention. | Ding P et al. | β | 2024 | β |
| Non-coding RNAs and angiogenesis in cardiovascular diseases: a comprehensive review. | Zhang J | β | 2024 | β |
| Not So Rare: Diseases Based on Mutant Proteins Controlling Endoplasmic Reticulum-Mitochondria Contact (MERC) Tethering. | Makio T et al. | β | 2024 | β |
| Obeticholic Acid Inhibit Mitochondria Dysfunction Via Regulating ERK1/2-DRP Pathway to Exert Protective Effect on Lipopolysaccharide-Induced Myocardial Injury. | Miao H et al. | β | 2024 | β |
| Obstructive Sleep Apnea-Associated Intermittent Hypoxia-Induced Immune Responses in Males, Pregnancies, and Offspring. | Song R et al. | β | 2024 | β |
| Oxidative stress and antioxidants in cataract development. | Lee B et al. | β | 2024 | β |
| Oxidative Stress and Bio-Regulation. | Yoshikawa T et al. | β | 2024 | β |
| Pepsin-mediated inflammation in laryngopharyngeal reflux via the ROS/NLRP3/IL-1Ξ² signaling pathway. | Tan JJ et al. | β | 2024 | β |
| Periodontal disease as a model to study chronic inflammation in aging. | Bertolini M et al. | β | 2024 | β |
| Piperlongumine inhibits esophageal squamous cell carcinoma in vitro and in vivo by triggering NRF2/ROS/TXNIP/NLRP3-dependent pyroptosis. | Cui Y et al. | β | 2024 | β |
| Potential mechanisms of ischemic stroke induced by heat exposure. | Zhou X et al. | β | 2024 | β |
| Prevention and alleviation of allergic rhinitis by oral administration of <i>Lacticaseibacillus paracasei</i> GOLDGUT-Lpc969. | Zhou X et al. | β | 2024 | β |
| Progress in the Correlation Between Inflammasome NLRP3 and Liver Fibrosis. | Sun M et al. | β | 2024 | β |
| Protective effects of scutellaria-coptis herb couple against non-alcoholic steatohepatitis via activating NRF2 and FXR pathways in vivo and in vitro. | Xue Y et al. | β | 2024 | β |
| Pyroptosis in Diabetic Peripheral Neuropathy and its Therapeutic Regulation. | Al Mamun A et al. | β | 2024 | β |
| Reactive Oxygen Species Mechanisms that Regulate Protein-Protein Interactions in Cancer. | Iliadis S et al. | β | 2024 | β |
| Recent advances in the treatment of gout with NLRP3 inflammasome inhibitors. | Tian Y et al. | β | 2024 | β |
| Redoxisome Update: TRX and TXNIP/TBP2-Dependent Regulation of NLRP-1/NLRP-3 Inflammasome. | Yoshihara E et al. | β | 2024 | β |
| Redox regulation of macrophages. | Tran N et al. | β | 2024 | β |
| Regulatory mechanism of the six-method massage antipyretic process on lipopolysaccharide-induced fever in juvenile rabbits: A targeted metabolomics approach. | Liu D et al. | β | 2024 | β |
| Research Progress of Pyroptosis in Diabetic Kidney Disease. | Fan Q et al. | β | 2024 | β |
| SGLT2 inhibitors and NLRP3 inflammasome: potential target in diabetic kidney disease. | Machado JΓΊnior PAB et al. | β | 2024 | β |
| S-glutathionylation in hepatocytes is involved in arsenic-induced liver fibrosis through activation of the NLRP3 inflammasome, an effect alleviated by NAC. | Li Z et al. | β | 2024 | β |
| Shexiang Tongxin dropping pills protect against ischemic stroke-induced cerebral microvascular dysfunction via suppressing TXNIP/NLRP3 signaling pathway. | Zhu L et al. | β | 2024 | β |
| Sulforaphane Inhibits Oxidative Stress and May Exert Anti-Pyroptotic Effects by Modulating NRF2/NLRP3 Signaling Pathway in <i>Mycobacterium tuberculosis</i>-Infected Macrophages. | Chen G et al. | β | 2024 | β |
| Tamping Down the Fire: Taming Pyroptosis through RNA Methylation in Acute Lung Injury. | Shin KWD et al. | β | 2024 | β |
| Targeting TXNIP in endothelial progenitors mitigates IL-8-induced neutrophil recruitment under metabolic stress. | Jolibois J et al. | β | 2024 | β |
| The absence of thioredoxin-interacting protein in alveolar cells exacerbates asthma during obesity. | Jeong JS et al. | β | 2024 | β |
| The Ameliorative Role of Lico A on Aflatoxin B<sub>1</sub>-Triggered Hepatotoxicity Partially by Activating Nrf2 Signal Pathway. | Lv H et al. | β | 2024 | β |
| The downregulation of SCGN induced by lipotoxicity promotes NLRP3-mediated Ξ²-cell pyroptosis. | Ouyang S et al. | β | 2024 | β |
| The effect and mechanism of freeze-dried powder of <i>Poecilobdella manillensis</i> on improving inflammatory injury of rat glomerular mesangial cells through TXNIP / NLRP3 pathway. | Sun X et al. | β | 2024 | β |
| The function of carnosic acid in lipopolysaccharides-induced hepatic and intestinal inflammation in poultry. | Wan SS et al. | β | 2024 | β |
| The Fungicide Ipconazole Can Activate Mediators of Cellular Damage in Rat Brain Regions. | VillaorduΓ±a C et al. | β | 2024 | β |
| The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome. | Stanton C et al. | β | 2024 | β |
| The Mechanism of Pyroptosis and Its Application Prospect in Diabetic Wound Healing. | Al Mamun A et al. | β | 2024 | β |
| The MondoA-dependent TXNIP/GDF15 axis predicts oxaliplatin response in colorectal adenocarcinomas. | Deng J et al. | β | 2024 | β |
| The role of endoplasmic reticulum-mitochondria-associated membranes in diabetic kidney disease. | Elwakiel A et al. | β | 2024 | β |
| The role of GΞ±q in regulating NLRP3 inflammasome activation. | Kong R et al. | β | 2024 | β |
| The role of NLRP3 and NLRP12 inflammasomes in glioblastoma. | Rajkhowa S et al. | β | 2024 | β |
| The ROS/TXNIP/NLRP3 pathway mediates LPS-induced microglial inflammatory response. | Zhao Q et al. | β | 2024 | β |
| The size-dependence and reversibility of polystyrene nanoplastics-induced hepatic pyroptosis in mice through TXNIP/NLRP3/GSDMD pathway. | Lu YY et al. | β | 2024 | β |
| Treponema pallidum recombinant protein Tp47 activates NOD-like receptor family protein 3 inflammasomes in macrophages via glycolysis. | Zheng XQ et al. | β | 2024 | β |
| TXNIP/NLRP3 aggravates global cerebral ischemia-reperfusion injury-induced cognitive decline in mice. | Yang C et al. | β | 2024 | β |
| Unraveling the role of NLRP3 inflammasome in allergic inflammation: implications for novel therapies. | Lu HF et al. | β | 2024 | β |
| Unraveling Verapamil's Multidimensional Role in Diabetes Therapy: From Ξ²-Cell Regeneration to Cholecystokinin Induction in Zebrafish and MIN6 Cell-Line Models. | Arefanian H et al. | β | 2024 | β |
| Unveiling the hidden pathways: Exploring astrocytes as a key target for depression therapy. | Liu Y et al. | β | 2024 | β |
| Vaccarin alleviates septic cardiomyopathy by potentiating NLRP3 palmitoylation and inactivation. | Zhu XX et al. | β | 2024 | β |
| Visit to visit transition in TXNIP gene methylation and the risk of type 2 diabetes mellitus: a nested case-control study. | Wu Y et al. | β | 2024 | β |
| Well-defined alginate oligosaccharides ameliorate joint pain and inflammation in a mouse model of gouty arthritis. | Yin C et al. | β | 2024 | β |
| Ξ²-cell neogenesis: A rising star to rescue diabetes mellitus. | Niu F et al. | β | 2024 | β |
| 3,4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury. | Zhang H et al. | β | 2023 | β |
| Activation of pyroptosis by specific organelle-targeting photodynamic therapy to amplify immunogenic cell death for anti-tumor immunotherapy. | Zeng S et al. | β | 2023 | β |
| A detailed molecular network map and model of the NLRP3 inflammasome. | Krantz M et al. | β | 2023 | β |
| Adiponectin inhibits LPS-induced nucleus pulposus cell pyroptosis through the miR-135a-5p/TXNIP signaling pathway. | Wu S et al. | β | 2023 | β |
| Advances in Understanding the Role of NRF2 in Liver Pathophysiology and Its Relationship with Hepatic-Specific Cyclooxygenase-2 Expression. | Fuertes-Agudo M et al. | β | 2023 | β |
| A high throughput screen for pharmacological inhibitors of the carbohydrate response element. | You S et al. | β | 2023 | β |
| A Supportive Role of Mesenchymal Stem Cells on Insulin-Producing Langerhans Islets with a Specific Emphasis on The Secretome. | Sionov RV et al. | β | 2023 | β |
| ATF5 is a regulator of ER stress and Ξ²-cell apoptosis in different mouse models of genetic- and diet-induced obesity and diabetes mellitus. | Ma J et al. | β | 2023 | β |
| A wild rice-derived peptide R14 ameliorates monosodium urate crystals-induced IL-1Ξ² secretion through inhibition of NF-ΞΊB signaling and NLRP3 inflammasome activation. | Charoenwutthikun S et al. | β | 2023 | β |
| Beyond Glucose: The Dual Assault of Oxidative and ER Stress in Diabetic Disorders. | Roohi TF et al. | β | 2023 | β |
| Bibliometric evaluation of publications on inflammasomes in atherosclerosis from 2002 to 2022. | Tan Y et al. | β | 2023 | β |
| Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis. | Bradfield CJ et al. | β | 2023 | β |
| Canonical and non-canonical functions of NLRP3. | Accogli T et al. | β | 2023 | β |
| Ca<sup>2+</sup>-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In Vitro. | Mu-U-Min RBA et al. | β | 2023 | β |
| Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway. | Jiang X et al. | β | 2023 | β |
| Cell Replacement Therapy for Type 1 Diabetes Patients: Potential Mechanisms Leading to Stem-Cell-Derived Pancreatic Ξ²-Cell Loss upon Transplant. | Shilleh AH et al. | β | 2023 | β |
| Characterisation of macrophage infiltration and polarisation based on integrated transcriptomic and histological analyses in Primary SjΓΆgren's syndrome. | Zong Y et al. | β | 2023 | β |
| Characterization of IMG Microglial Cell Line as a Valuable In Vitro Tool for NLRP3 Inflammasome Studies. | Viil J et al. | β | 2023 | β |
| Characterization of Inflammasomes and Their Regulation in the Red Fox. | Ahn H et al. | β | 2023 | β |
| CHIP Haploinsufficiency Exacerbates Hepatic Steatosis via Enhanced TXNIP Expression and Endoplasmic Reticulum Stress Responses. | Han JH et al. | β | 2023 | β |
| Chronic cold stress-induced myocardial injury: effects on oxidative stress, inflammation and pyroptosis. | Lv H et al. | β | 2023 | β |
| CIRC_0001818 TARGETS MIR-136-5P TO INCREASE LIPOPOLYSACCHARIDE-INDUCED HK2 CELL INJURIES BY ACTIVATING TXNIP/NLRP3 INFLAMMASOME PATHWAY. | Kuang F et al. | β | 2023 | β |
| Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells. | BΓ©quignon OJM et al. | β | 2023 | β |
| Common Pathogenetic Pathways of Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus. | Giannopoulos CK et al. | β | 2023 | β |
| Convergence of Fructose-Induced NLRP3 Activation with Oxidative Stress and ER Stress Leading to Hepatic Steatosis. | Singh S et al. | β | 2023 | β |
| Curcumin ameliorates chronic <i>Toxoplasma gondii</i> infection-induced affective disorders through modulation of proinflammatory cytokines and oxidative stress. | Moradi F et al. | β | 2023 | β |
| Danger signals released during cold ischemia storage activate NLRP3 inflammasome in myeloid cells and influence early allograft function in liver transplantation. | Lucas-Ruiz F et al. | β | 2023 | β |
| Diesel Exhaust Particle (DEP)-induced glucose intolerance is driven by an intestinal innate immune response and NLRP3 activation in mice. | Bosch AJT et al. | β | 2023 | β |
| Diet's Role in Modifying Risk of Alzheimer's Disease: History and Present Understanding. | Grant WB et al. | β | 2023 | β |
| Down regulation of NDUFS1 is involved in the progression of parenteral-nutrition-associated liver disease by increasing Oxidative stress. | Wan S et al. | β | 2023 | β |
| Dual Role of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 in Inflammasome and Pancreatic Ξ²-Cell Function. | Saeed R et al. | β | 2023 | β |
| Effectiveness of targeting the NLRP3 inflammasome by using natural polyphenols: A systematic review of implications on health effects. | Wang T et al. | β | 2023 | β |
| Effects of dexmedetomidine on A549 non-small cell lung cancer growth in a clinically relevant surgical xenograft model. | Jun JH et al. | β | 2023 | β |
| Effects of polyunsaturated fatty acid supplementation on plasma and follicular fluid resolvin D1 concentration and mRNA abundance in granulosa cells in ewes. | Carranza-Martin AC et al. | β | 2023 | β |
| Efficacy of traditional Chinese medicine on diabetic cardiomyopathy in animal models: a systematic review and meta-analysis. | Hu L et al. | β | 2023 | β |
| Electroacupuncture improves gout arthritis pain via attenuating ROS-mediated NLRP3 inflammasome overactivation. | Wei H et al. | β | 2023 | β |
| Entrectinib inhibits NLRP3 inflammasome and inflammatory diseases by directly targeting NEK7. | Jin X et al. | β | 2023 | β |
| Exercise suppresses neuroinflammation for alleviating Alzheimer's disease. | Wang M et al. | β | 2023 | β |
| Exercise training-attenuated insulin resistance and liver injury in elderly pre-diabetic patients correlates with NLRP3 inflammasome. | Zhang T et al. | β | 2023 | β |
| Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications. | Li N et al. | β | 2023 | β |
| Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives. | Sun K et al. | β | 2023 | β |
| Formulation strategies to provide oxygen-release to contrast local hypoxia for transplanted islets. | Wang Z et al. | β | 2023 | β |
| FoxO1/NLRP3 Inflammasome Promotes Age-Related Alveolar Bone Resorption. | Wang Z et al. | β | 2023 | β |
| From Innate Immunity to Metabolic Disorder: A Review of the NLRP3 Inflammasome in Diabetes Mellitus. | NiΘulescu IM et al. | β | 2023 | β |
| Fundamental Neurochemistry Review: Microglial immunometabolism in traumatic brain injury. | Strogulski NR et al. | β | 2023 | β |
| Golgi Apparatus-Targeted Photodynamic Therapy for Enhancing Tumor Immunogenicity by Eliciting NLRP3 Protein-Dependent Pyroptosis. | Hu ZC et al. | β | 2023 | β |
| Gossypetin Prevents the Progression of Nonalcoholic Steatohepatitis by Regulating Oxidative Stress and AMP-Activated Protein Kinase. | Oh E et al. | β | 2023 | β |
| Heme oxygenase-1 ameliorates endotoxin-induced acute lung injury by modulating macrophage polarization via inhibiting TXNIP/NLRP3 inflammasome activation. | Wu X et al. | β | 2023 | β |
| Hesperetin attenuates cognitive dysfunction via SIRT6/NLRP3 pathway in scopolamine-induced mice. | Jing S et al. | β | 2023 | β |
| Homocysteine promotes atherosclerosis through macrophage pyroptosis via endoplasmic reticulum stress and calcium disorder. | Zhang S et al. | β | 2023 | β |
| Identification and analysis of hub genes of hypoxia-immunity in type 2 diabetes mellitus. | Li J et al. | β | 2023 | β |
| <i>Hyptis obtusiflora</i> C. Presl ex Benth Methanolic Extract Exhibits Anti-Inflammatory and Anti-Gastritis Activities via Suppressing AKT/NF-ΞΊB Pathway. | Oh J et al. | β | 2023 | β |
| Immune Mechanisms in Epileptogenesis: Update on Diagnosis and Treatment of Autoimmune Epilepsy Syndromes. | Flammer J et al. | β | 2023 | β |
| <i>Mycobacterium tuberculosis</i> Central Metabolism Is Key Regulator of Macrophage Pyroptosis and Host Immunity. | Maxson ME et al. | β | 2023 | β |
| Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming. | Chen LC et al. | β | 2023 | β |
| Increased serum extracellular vesicle miR-144-3p and miR-486a-3p in a mouse model of adipose tissue regeneration promote hepatocyte proliferation by targeting Txnip. | Niitsu Y et al. | β | 2023 | β |
| Inflammasome activation by viral infection: mechanisms of activation and regulation. | Shi W et al. | β | 2023 | β |
| Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: A comprehensive overview. | Kattan D et al. | β | 2023 | β |
| Inhibition of Galectins and the P2X7 Purinergic Receptor as a Therapeutic Approach in the Neurovascular Inflammation of Diabetic Retinopathy. | Lepre CC et al. | β | 2023 | β |
| Integrated epigenome, whole genome sequence and metabolome analyses identify novel multi-omics pathways in type 2 diabetes: a Middle Eastern study. | Yousri NA et al. | β | 2023 | β |
| <i>Txnip</i> expression promotes JNK-mediated neuronal death in response to reactive oxygen species. | GarcΓa-HernΓ‘ndez B et al. | β | 2023 | β |
| Knocking down GALNT6 promotes pyroptosis of pancreatic ductal adenocarcinoma cells through NF-ΞΊB/NLRP3/GSDMD and GSDME signaling pathway. | Ding M et al. | β | 2023 | β |
| Leukocyte-endothelial interaction in CKD. | Sarakpi T et al. | β | 2023 | β |
| LncRNA MHRT Prevents Angiotensin II-Induced Myocardial Oxidative Stress and NLRP3 Inflammasome via Nrf2 Activation. | Liu P et al. | β | 2023 | β |
| Local glucose elevation activates pyroptosis via NLRP3 inflammasome in ovarian granulosa cells of overweight patients. | Xu R et al. | β | 2023 | β |
| MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury. | Yu B et al. | β | 2023 | β |
| MARCH5 promotes STING pathway activation by suppressing polymer formation of oxidized STING. | Son K et al. | β | 2023 | β |
| Mechanism of RNA m<sup>6</sup> A methylation modification regulating NLRP3 inflammasome activation for hand, foot, and mouth disease progression. | Hu Q et al. | β | 2023 | β |
| Mechanisms Underlying the Effects of the Green Tea Polyphenol EGCG in Sarcopenia Prevention and Management. | Wang T et al. | β | 2023 | β |
| Microglial NLRP3 inflammasome activation mediates diabetes-induced depression-like behavior via triggering neuroinflammation. | Su WJ et al. | β | 2023 | β |
| miRNAs associated with endoplasmic reticulum stress and unfolded protein response during decidualization. | Soczewski E et al. | β | 2023 | β |
| Mitochondrial control of inflammation. | Marchi S et al. | β | 2023 | β |
| Mitochondrial-derived vesicles in skeletal muscle remodeling and adaptation. | Picca A et al. | β | 2023 | β |
| Mitochondrial dysfunction: A fatal blow in depression. | Song Y et al. | β | 2023 | β |
| Mitochondrial dysfunction and oxidative stress: Role in chronic kidney disease. | Srivastava A et al. | β | 2023 | β |
| Modulation of NLRP3 inflammasomes activation contributes to improved survival and function of mesenchymal stromal cell spheroids. | Pham DV et al. | β | 2023 | β |
| Molecular Link between Glo-1 Expression and Markers of Hyperglycemia and Oxidative Stress in Vascular Complications of Type 2 Diabetes Mellitus. | Syed NA et al. | β | 2023 | β |
| Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis. | Tuli HS et al. | β | 2023 | β |
| Molecular pathways of NF-ΔΈB and NLRP3 inflammasome as potential targets in the treatment of inflammation in diabetic wounds: A review. | Teh HX et al. | β | 2023 | β |
| NADPH Oxidase-Mediated Testicular Oxidative Imbalance Regulates the TXNIP/NLRP3 Inflammasome Axis Activation after Ischemia Reperfusion Injury. | Almarzouq D et al. | β | 2023 | β |
| Native low-density lipoproteins are priming signals of the NLRP3 inflammasome/interleukin-1Ξ² pathway in human adipose tissue and macrophages. | Bissonnette S et al. | β | 2023 | β |
| Natural products in attenuating renal inflammation <i>via</i> inhibiting the NLRP3 inflammasome in diabetic kidney disease. | Wang Y et al. | β | 2023 | β |
| Neuroprotection impact of biochanin A against pentylenetetrazol-kindled mice: Targeting NLRP3 inflammasome/TXNIP pathway and autophagy modulation. | El-Sayed RM et al. | β | 2023 | β |
| Nifuroxazide mitigates doxorubicin-induced cardiovascular injury: Insight into oxidative/NLRP3/GSDMD-mediated pyroptotic signaling modulation. | Amin FM et al. | β | 2023 | β |
| NLR family pyrin domain containing 3 (NLRP3) inflammasomes and peripheral neuropathic pain - Emphasis on microRNAs (miRNAs) as important regulators. | Basu P et al. | β | 2023 | β |
| NLRP3 Inflammasome: An Emerging Therapeutic Target for Alzheimer's Disease. | Tao S et al. | β | 2023 | β |
| NLRP3 Inflammasome as Therapeutic Targets in Inflammatory Diseases. | Prakash AV et al. | β | 2023 | β |
| NLRP3 inflammasome in hepatic diseases: A pharmacological target. | Ramos-Tovar E et al. | β | 2023 | β |
| NLRP3 Inflammasome-Targeting Nanomicelles for Preventing Ischemia-Reperfusion-Induced Inflammatory Injury. | Prakash R et al. | β | 2023 | β |
| NOD-like Receptors-Emerging Links to Obesity and Associated Morbidities. | Bauer S et al. | β | 2023 | β |
| On the Chemical and Biological Characteristics of Multifunctional Compounds for the Treatment of Parkinson's Disease. | GarcΓa-BeltrΓ‘n O et al. | β | 2023 | β |
| Ox-inflammasome involvement in neuroinflammation. | Vallese A et al. | β | 2023 | β |
| Perfluorodecanoic acid promotes adipogenesis via NLRP3 inflammasome-mediated pathway in HepG2 and 3T3-L1 cells. | Wang T et al. | β | 2023 | β |
| Perfluorodecanoic acid promotes high-fat diet-triggered adiposity and hepatic lipid accumulation by modulating the NLRP3/caspase-1 pathway in male C57BL/6J mice. | Wang T et al. | β | 2023 | β |
| Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction. | Ma Q | β | 2023 | β |
| Physical Activity as a Modern Intervention in the Fight against Obesity-Related Inflammation in Type 2 Diabetes Mellitus and Gestational Diabetes. | Piotrowska K et al. | β | 2023 | β |
| Physiological and Pathophysiological Roles of Thioredoxin Interacting Protein: A Perspective on Redox Inflammation and Metabolism. | Dagdeviren S et al. | β | 2023 | β |
| Physiological role of cytokines in the regulation of mammalian metabolism. | de Baat A et al. | β | 2023 | β |
| Piperine mitigates aortic vasculopathy in streptozotocin-diabetic rats via targeting TXNIP-NLRP3 signaling. | Amin FM et al. | β | 2023 | β |
| Polyphenols as NLRP3 inflammasome modulators in cardiometabolic diseases: a review of <i>in vivo</i> studies. | Villalva M et al. | β | 2023 | β |
| Protein-protein interactions and related inhibitors involved in the NLRP3 inflammasome pathway. | Ma ZY et al. | β | 2023 | β |
| Pyroptosis, apoptosis, and autophagy are involved in infection induced by two clinical <i>Klebsiella pneumoniae</i> isolates with different virulence. | Wang X et al. | β | 2023 | β |
| Pyroptosis in neurodegenerative diseases: What lies beneath the tip of the iceberg? | Yue M et al. | β | 2023 | β |
| Quercetin inhibits the NOX2/ROS-mediated NF-ΞΊB/TXNIP signaling pathway to ameliorate pyroptosis of cardiomyocytes to relieve sepsis-induced cardiomyopathy. | Zhao H et al. | β | 2023 | β |
| Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy. | Liu J et al. | β | 2023 | β |
| Recent advances in pyroptosis, liver disease, and traditional Chinese medicine: A review. | He W et al. | β | 2023 | β |
| Role of NLRP3 Inflammasome and Its Inhibitors as Emerging Therapeutic Drug Candidate for Alzheimer's Disease: a Review of Mechanism of Activation, Regulation, and Inhibition. | Sharma B et al. | β | 2023 | β |
| Role of SIRT3 in neurological diseases and rehabilitation training. | Li Y et al. | β | 2023 | β |
| Role of the inflammasome in insulin resistance and type 2 diabetes mellitus. | Lu S et al. | β | 2023 | β |
| (R,R)-BD-AcAc2 Mitigates Chronic Colitis in Rats: A Promising Multi-Pronged Approach Modulating Inflammasome Activity, Autophagy, and Pyroptosis. | Saber S et al. | β | 2023 | β |
| Salidroside protects pancreatic Ξ²-cells against pyroptosis by regulating the NLRP3/GSDMD pathway in diabetic conditions. | Zhou J et al. | β | 2023 | β |
| SIRT1 Inhibits High Glucose-Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation. | Lian L et al. | β | 2023 | β |
| Targeting the NLRP3 inflammasome in diabetic retinopathy: From pathogenesis to therapeutic strategies. | Yang Y et al. | β | 2023 | β |
| Theaflavin mitigates acute gouty peritonitis and septic organ injury in mice by suppressing NLRP3 inflammasome assembly. | Chen SY et al. | β | 2023 | β |
| The Effects of Curcumin on Inflammasome: Latest Update. | Benameur T et al. | β | 2023 | β |
| The functional change of the P2X7R containing the Ala<sup>348</sup> to Thr polymorphism is associated with the pathogenesis of gout. | Li MY et al. | β | 2023 | β |
| The Function of MondoA and ChREBP Nutrient-Sensing Factors in Metabolic Disease. | Ahn B | β | 2023 | β |
| The Gut-Brain Axis as a Therapeutic Target in Multiple Sclerosis. | Buga AM et al. | β | 2023 | β |
| The ideal treatment timing for diabetic retinopathy: the molecular pathological mechanisms underlying early-stage diabetic retinopathy are a matter of concern. | Sun WJ et al. | β | 2023 | β |
| The Influence of Gut Microbiota on Oxidative Stress and the Immune System. | Kunst C et al. | β | 2023 | β |
| The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in diabetic retinopathy. | Zheng X et al. | β | 2023 | β |
| The NLRP3 inflammasome: contributions to inflammation-related diseases. | Chen Y et al. | β | 2023 | β |
| The NLRP3 inflammasome in viral infection (Review). | Zheng Q et al. | β | 2023 | β |
| The NLRP3 inflammasome rs35829419 C>A polymorphism is associated with type 2 diabetes mellitus in Saudi Arabia. | Kaabi YA | β | 2023 | β |
| The paradigm of prophylactic viral outbreaks measures by microbial biosurfactants. | Kumari K et al. | β | 2023 | β |
| Therapeutic effects of traditional Chinese medicine on gouty nephropathy: Based on NF-ΞΊB signalingpathways. | Liu P et al. | β | 2023 | β |
| The relationship between atrial fibrillation and NLRP3 inflammasome: a gut microbiota perspective. | Xing Y et al. | β | 2023 | β |
| The Role of NLRP3 Inflammasome in Obesity and PCOS-A Systematic Review and Meta-Analysis. | Alenezi SA et al. | β | 2023 | β |
| The Role of Obesity in Breast Cancer Pathogenesis. | Glassman I et al. | β | 2023 | β |
| The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control. | Deng J et al. | β | 2023 | β |
| The roles of inflammasomes in cancer. | Deng Z et al. | β | 2023 | β |
| The thioredoxin system: Balancing redox responses in immune cells and tumors. | Muri J et al. | β | 2023 | β |
| The Tricky Connection between Extracellular Vesicles and Mitochondria in Inflammatory-Related Diseases. | Di Mambro T et al. | β | 2023 | β |
| Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor HL23, a fangchinoline derivative, in human hepatocellular carcinoma. | Lu Y et al. | β | 2023 | β |
| Thioredoxin Interacting Protein Inhibitors in Diabetes Mellitus: A Critical Review. | Kar A et al. | β | 2023 | β |
| Thioredoxin Signaling Pathways in Cancer. | Zhang J et al. | β | 2023 | β |
| Tivantinib alleviates inflammatory diseases by directly targeting NLRP3. | Huang Y et al. | β | 2023 | β |
| TNFΞ±-induced NLRP3 inflammasome mediates adipocyte dysfunction and activates macrophages through adipocyte-derived lipocalin 2. | Javaid HMA et al. | β | 2023 | β |
| Treating diabetes with combination of phosphodiesterase 5 inhibitors and hydroxychloroquine-aΒ possible prevention strategy for COVID-19? | Kukreja RC et al. | β | 2023 | β |
| TXNIP activates NLRP3/IL-1Ξ² and participate in inflammatory response and oxidative stress to promote deep venous thrombosis. | Fei J et al. | β | 2023 | β |
| TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target. | Choi EH et al. | β | 2023 | β |
| TXNIP Exacerbates the Senescence and Aging-Related Dysfunction of Ξ² Cells by Inducing Cell Cycle Arrest Through p38-p16/p21-CDK-Rb Pathway. | Li Y et al. | β | 2023 | β |
| TXNIP inhibition in the treatment of type 2 diabetes mellitus: design, synthesis, and biological evaluation of quinazoline derivatives. | Li A et al. | β | 2023 | β |
| Ubiquitin-specific peptidase 25 exacerbated osteoarthritis progression through facilitating TXNIP ubiquitination and NLRP3 inflammasome activation. | Sui J et al. | β | 2023 | β |
| Ultra-High Temperature Treatment of Liquid Infant Formula, Systemic Immunity, and Kidney Development in Preterm Neonates. | Sun J et al. | β | 2023 | β |
| Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress. | Ong G et al. | β | 2023 | β |
| Upregulation of TXNIP contributes to granulosa cell dysfunction in polycystic ovary syndrome via activation of the NLRP3 inflammasome. | Wang Y et al. | β | 2023 | β |
| USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein. | Shi S et al. | β | 2023 | β |
| VDUP1 Deficiency Promotes the Severity of DSS-Induced Colitis in Mice by Inducing Macrophage Infiltration. | Park KH et al. | β | 2023 | β |
| Verapamil attenuates intervertebral disc degeneration by suppressing ROS overproduction and pyroptosis via targeting the Nrf2/TXNIP/NLRP3 axis in four-week puncture-induced rat models both in vivo and in vitro. | Chen Y et al. | β | 2023 | β |
| Verapamil chronicles: advances from cardiovascular to pancreatic Ξ²-cell protection. | Arefanian H et al. | β | 2023 | β |
| Verapamil-loaded supramolecular hydrogel patch attenuates metabolic dysfunction-associated fatty liver disease via restoration of autophagic clearance of aggregated proteins and inhibition of NLRP3. | Kim DK et al. | β | 2023 | β |
| What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome research. | Nagar A et al. | β | 2023 | β |
| Abnormal cannabidiol ameliorates inflammation preserving pancreatic beta cells in mouse models of experimental type 1 diabetes and beta cell damage. | GonzΓ‘lez-Mariscal I et al. | β | 2022 | β |
| Activation and regulation mechanisms of NOD-like receptors based on structural biology. | Ohto U | β | 2022 | β |
| Activation and Regulation of NLRP3 by Sterile and Infectious Insults. | Banerjee SK et al. | β | 2022 | β |
| Activation of TLR4 induces severe acute pancreatitis-associated spleen injury via ROS-disrupted mitophagy pathway. | Wen E et al. | β | 2022 | β |
| Acupuncture at ST36 Alleviates the Behavioral Disorder of Autistic Rats by Inhibiting TXNIP-Mediated Activation of NLRP3. | Zhao P et al. | β | 2022 | β |
| AGE-TXNIP axis drives inflammation in Alzheimer's by targeting AΞ² to mitochondria in microglia. | Sbai O et al. | β | 2022 | β |
| AIP1 suppresses neovascularization by inhibiting the NOX4-induced NLRP3/NLRP6 imbalance in a murine corneal alkali burn model. | Li Q et al. | β | 2022 | β |
| Alleviating effects of pea peptide on oxidative stress injury induced by lead in PC12 cells <i>via</i> Keap1/Nrf2/TXNIP signaling pathway. | Li N et al. | β | 2022 | β |
| An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway. | Yang J et al. | β | 2022 | β |
| A Novel Long-Noncoding RNA LncZFAS1 Prevents MPP<sup>+</sup>-Induced Neuroinflammation Through MIB1 Activation. | Zhu Z et al. | β | 2022 | β |
| Anti-inflammatory effect of glucagon-like Peptide-1 receptor agonist on the neurosensory retina in an acute optic nerve injury rat model. | Chung YW et al. | β | 2022 | β |
| Antioxidant Effect of Coenzyme Q10 in the Prevention of Oxidative Stress in Arsenic-Treated CHO-K1 Cells and Possible Participation of Zinc as a Pro-Oxidant Agent. | Silva SVE et al. | β | 2022 | β |
| Artesunate protects pancreatic Ξ²-cells from streptozotocin-induced diabetes via inhibition of the NLRP3/caspase-1/GSDMD pathway. | Yuan J et al. | β | 2022 | β |
| Artificial Intelligence-Assisted Bioinformatics, Microneedle, and Diabetic Wound Healing: A "New Deal" of an Old Drug. | Xue Y et al. | β | 2022 | β |
| A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6. | Jeltema D et al. | β | 2022 | β |
| A small molecule inhibitor of caspase-1 inhibits NLRP3 inflammasome activation and pyroptosis to alleviate gouty inflammation. | Cao DY et al. | β | 2022 | β |
| Association of drinking behaviors with <i>TXNIP</i> DNA methylation levels in leukocytes among the general Japanese population. | Maeda K et al. | β | 2022 | β |
| Attenuation of ROS/Chloride Efflux-Mediated NLRP3 Inflammasome Activation Contributes to Alleviation of Diabetic Cardiomyopathy in Rats after Sleeve Gastrectomy. | Li S et al. | β | 2022 | β |
| A Viral Long Non-Coding RNA Protects against Cell Death during Human Cytomegalovirus Infection of CD14+ Monocytes. | Perera MR et al. | β | 2022 | β |
| Balancing life and death: BCL-2 family members at diverse ER-mitochondrial contact sites. | Means RE et al. | β | 2022 | β |
| Beneficial Effects of Melatonin on Periodontitis Management: Far More Than Oral Cavity. | Wang C et al. | β | 2022 | β |
| Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D-mediated pyroptosis. | An C et al. | β | 2022 | β |
| Blocking CHOP-dependent TXNIP shuttling to mitochondria attenuates albuminuria and mitigates kidney injury in nephrotic syndrome. | Park SJ et al. | β | 2022 | β |
| Branched ubiquitin code: from basic biology to targeted protein degradation. | Ohtake F | β | 2022 | β |
| Bromocriptine-QR Therapy Reduces Sympathetic Tone and Ameliorates a Pro-Oxidative/Pro-Inflammatory Phenotype in Peripheral Blood Mononuclear Cells and Plasma of Type 2 Diabetes Subjects. | Cincotta AH et al. | β | 2022 | β |
| Calycosin modulates NLRP3 and TXNIP-mediated pyroptotic signaling and attenuates diabetic nephropathy progression in diabetic rats; An insight. | Yosri H et al. | β | 2022 | β |
| Caspase-1 and Cathepsin B Inhibitors from Marine Invertebrates, Aiming at a Reduction in Neuroinflammation. | Moreno RI et al. | β | 2022 | β |
| Caspase-1: A Promising Target for Preserving Blood-Brain Barrier Integrity in Acute Stroke. | Ye X et al. | β | 2022 | β |
| Celastrol inhibits TXNIP expression to protect pancreatic Ξ² cells in diabetic mice. | Wang SW et al. | β | 2022 | β |
| Ceramide induces pyroptosis through TXNIP/NLRP3/GSDMD pathway in HUVECs. | Liu F et al. | β | 2022 | β |
| Changes in plasma IRAK-M in patients with prediabetes and its relationship with related metabolic indexes: a cross-sectional study. | Xie X et al. | β | 2022 | β |
| ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation. | Zhang J et al. | β | 2022 | β |
| Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like dermatitis in mice. | Chen Y et al. | β | 2022 | β |
| Cochlear Marginal Cell Pyroptosis Is Induced by Cisplatin <i>via</i> NLRP3 Inflammasome Activation. | Yu W et al. | β | 2022 | β |
| Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse. | Kim JS et al. | β | 2022 | β |
| Combined effects of nucleotide-binding domain-like receptor protein 3 polymorphisms and environmental metals exposure on chronic kidney disease. | Hsueh YM et al. | β | 2022 | β |
| Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation. | Luo T et al. | β | 2022 | β |
| CX3CL1 Derived from Bone Marrow Mesenchymal Stem Cells Inhibits A<i>Ξ²</i> <sub>1-42</sub>-Induced SH-SY5Y Cell Pathological Damage through TXNIP/NLRP3 Signaling Pathway. | Guo C et al. | β | 2022 | β |
| DAMPs Released From Injured Renal Tubular Epithelial Cells Activate Innate Immune Signals in Healthy Renal Tubular Epithelial Cells. | DeWolf SE et al. | β | 2022 | β |
| Defective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in Ξ²-Cells. | Khilji MS et al. | β | 2022 | β |
| Determination of miR-373 and miR-204 levels in neuronal exosomes in Alzheimer's disease. | TaΕdelen E et al. | β | 2022 | β |
| Development of Intestinal Injury and Restoration of Weaned Piglets under Chronic Immune Stress. | Yu J et al. | β | 2022 | β |
| Diabesity in Elderly Cardiovascular Disease Patients: Mechanisms and Regulators. | GarcΓa-Vega D et al. | β | 2022 | β |
| Dietary prenylated flavonoid xanthohumol alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation. | Lu X et al. | β | 2022 | β |
| Diet-induced obesity impairs spermatogenesis: the critical role of NLRP3 in Sertoli cells. | Mu Y et al. | β | 2022 | β |
| Dose-dependent renoprotective impact of Lactoferrin against glycerol-induced rhabdomyolysis and acute kidney injury. | Madkour AH et al. | β | 2022 | β |
| Down-expression of the NLRP3 inflammasome delays the progression of diabetic retinopathy. | Ge K et al. | β | 2022 | β |
| Dysregulation of the NLRP3 Inflammasome in Diabetic Retinopathy and Potential Therapeutic Targets. | Raman KS et al. | β | 2022 | β |
| Effect of parthenolide, an NLRP3 inflammasome inhibitor, on insulin resistance in high-fat diet-obese mice. | Chinta PK et al. | β | 2022 | β |
| Effects of Luteinizing Hormone Releasing Hormone A2 on Gonad Development in Juvenile Amur Sturgeon, Acipenser schrenckii, Revealed by Transcriptome Profiling Analysis. | Lv W et al. | β | 2022 | β |
| Embryonic Deletion of TXNIP in GABAergic Neurons Enhanced Oxidative Stress in PV+ Interneurons in Primary Somatosensory Cortex of Aging Mice: Relevance to Schizophrenia. | Xue T et al. | β | 2022 | β |
| Empagliflozin suppresses urinary mitochondrial DNA copy numbers and interleukin-1Ξ² in type 2 diabetes patients. | Lee H et al. | β | 2022 | β |
| Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation During Hypercholesterolemia. | Yuan X et al. | β | 2022 | β |
| Energy restriction induced SIRT6 inhibits microglia activation and promotes angiogenesis in cerebral ischemia via transcriptional inhibition of TXNIP. | Song MY et al. | β | 2022 | β |
| Evaluation of Major Constituents of Medicinally Important Plants for Anti-Inflammatory, Antidiabetic and AGEs Inhibiting Properties: In Vitro and Simulatory Evidence. | Rafey A et al. | β | 2022 | β |
| Exercise reduces the protein abundance of TXNIP and its interacting partner REDD1 in skeletal muscle: potential role for a PKA-mediated mechanism. | Chaves AB et al. | β | 2022 | β |
| ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during <i>Pseudomonas aeruginosa</i> Infection. | Hardy KS et al. | β | 2022 | β |
| Expression and Mechanism of TXNIP/NLRP3 Inflammasome in Sciatic Nerve of Type 2 Diabetic Rats. | Han L et al. | β | 2022 | β |
| Extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells alleviates myocardial injury by targeting thioredoxin-interacting protein-mediated hypoxia-inducible factor-1Ξ± pathway. | Mao CY et al. | β | 2022 | β |
| Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review). | Zhang X et al. | β | 2022 | β |
| Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway. | Liu Y et al. | β | 2022 | β |
| Gene Delivery of Manf to Beta-Cells of the Pancreatic Islets Protects NOD Mice from Type 1 Diabetes Development. | Singh K et al. | β | 2022 | β |
| Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury. | Li H et al. | β | 2022 | β |
| Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1. | Zhou S et al. | β | 2022 | β |
| Harnessing immune response using reactive oxygen Species-Generating/Eliminating inorganic biomaterials for disease treatment. | Zhao C et al. | β | 2022 | β |
| High Endogenously Synthesized N-3 Polyunsaturated Fatty Acids in Fat-1 Mice Attenuate High-Fat Diet-Induced Insulin Resistance by Inhibiting NLRP3 Inflammasome Activation via Akt/GSK-3Ξ²/TXNIP Pathway. | Zhu P et al. | β | 2022 | β |
| Hunting down NLRP3 inflammasome: An executioner of radiation-induced injury. | Cheng H et al. | β | 2022 | β |
| Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1Ξ² Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells. | Surabhi S et al. | β | 2022 | β |
| Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats. | Zheng J et al. | β | 2022 | β |
| Immunomodulatory Role of Thioredoxin Interacting Protein in Cancer's Impediments: Current Understanding and Therapeutic Implications. | Katturajan R et al. | β | 2022 | β |
| Immunostimulatory Polymers as Adjuvants, Immunotherapies, and Delivery Systems. | Weiss AM et al. | β | 2022 | β |
| Implication of mitochondrial ROS-NLRP3 inflammasome axis during two-hit mediated acute lung injury in mice. | Puri G et al. | β | 2022 | β |
| Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1Ξ² secretion from human PBMCs. | Janciauskiene S et al. | β | 2022 | β |
| Inflammasome Complexes: Crucial mediators in osteoimmunology and bone diseases. | Zhou F et al. | β | 2022 | β |
| Inflammasomes: Cause or consequence of obesity-associated comorbidities in humans. | Herrera-MartΓnez AD et al. | β | 2022 | β |
| Inflammasome-targeting natural compounds in inflammatory bowel disease: Mechanisms and therapeutic potential. | Xu Q et al. | β | 2022 | β |
| Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): Relevant signaling pathways and therapeutic strategies. | Jin J et al. | β | 2022 | β |
| Inflammation in obesity, diabetes, and related disorders. | Rohm TV et al. | β | 2022 | β |
| Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease. | Michailidou Z et al. | β | 2022 | β |
| Innate metabolic responses against viral infections. | Palmer CS | β | 2022 | β |
| Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart. | Nakayama Y et al. | β | 2022 | β |
| Involvement of Inflammasome Components in Kidney Disease. | Aranda-Rivera AK et al. | β | 2022 | β |
| Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization <i>via</i> GPR35. | Sun T et al. | β | 2022 | β |
| Localization of Thioredoxin-Interacting Protein in Aging and Alzheimer's Disease Brains. | Tsubaki H et al. | β | 2022 | β |
| Loop Between NLRP3 Inflammasome and Reactive Oxygen Species. | Dominic A et al. | β | 2022 | β |
| Macrophages in obesity are characterised by increased IL-1Ξ² response to calcium-sensing receptor signals. | Thrum S et al. | β | 2022 | β |
| Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy. | Fan H et al. | β | 2022 | β |
| MCC950 in the treatment of NLRP3-mediated inflammatory diseases: Latest evidence and therapeutic outcomes. | Bakhshi S et al. | β | 2022 | β |
| Mechanism of mitigating effect of wheat germ peptides on lead-induced oxidative damage in PC12 cells. | Li N et al. | β | 2022 | β |
| Metabolic Dysfunction in the Regulation of the NLRP3 Inflammasome Activation: A Potential Target for Diabetic Nephropathy. | Zhao W et al. | β | 2022 | β |
| Metabolic Syndrome and Vascular-Associated Cognitive Impairment: a Focus on Preclinical Investigations. | Jenkins TA | β | 2022 | β |
| miR-17-5p Promotes Glucose Uptake of HTR8/SVneo Trophoblast Cells by Inhibiting TXNIP/NLRP3 Inflammasome Pathway. | Jiang Y et al. | β | 2022 | β |
| Mitochondria-endoplasmic reticulum contacts in sepsis-induced myocardial dysfunction. | Jiang T et al. | β | 2022 | β |
| Mitochondria-Endoplasmic Reticulum Contacts: The Promising Regulators in Diabetic Cardiomyopathy. | Chen Y et al. | β | 2022 | β |
| Molecular mechanisms and functions of pyroptosis in sepsis and sepsis-associated organ dysfunction. | Wen R et al. | β | 2022 | β |
| Myristoyl lysophosphatidylcholine is a biomarker and potential therapeutic target for community-acquired pneumonia. | Nan W et al. | β | 2022 | β |
| Neuroinflammation and COVID-19 Ischemic Stroke Recovery-Evolving Evidence for the Mediating Roles of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis and NLRP3 Inflammasome. | Che Mohd Nassir CMN et al. | β | 2022 | β |
| Neuroinflammation, Sleep, and Circadian Rhythms. | Zielinski MR et al. | β | 2022 | β |
| New insights and advances of sodium-glucose cotransporter 2 inhibitors in heart failure. | Li J et al. | β | 2022 | β |
| Nicorandil protects against coronary microembolization-induced myocardial injury by suppressing cardiomyocyte pyroptosis via the AMPK/TXNIP/NLRP3 signaling pathway. | Liu Y et al. | β | 2022 | β |
| N-Lobe of TXNIP Is Critical in the Allosteric Regulation of NLRP3 <i>via</i> TXNIP Binding. | Cheng F et al. | β | 2022 | β |
| NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity. | Amin S et al. | β | 2022 | β |
| NLRP3 inflammasome activation mechanism and its role in autoimmune liver disease. | Guan Y et al. | β | 2022 | β |
| NLRP3 Inflammasome and Pyroptosis in Liver Pathophysiology: The Emerging Relevance of Nrf2 Inducers. | Hurtado-Navarro L et al. | β | 2022 | β |
| NLRP3 inflammasome as a key driver of vascular disease. | Takahashi M | β | 2022 | β |
| NLRP3 Inflammasome Pharmacological Inhibitors in <i>Glycyrrhiza</i> for NLRP3-Driven Diseases Treatment: Extinguishing the Fire of Inflammation. | Wang Z et al. | β | 2022 | β |
| NLRP3 Inflammasome/Pyroptosis: A Key Driving Force in Diabetic Cardiomyopathy. | Zhang L et al. | β | 2022 | β |
| NLRP3 inflammasome: The rising star in cardiovascular diseases. | Zheng Y et al. | β | 2022 | β |
| NLRP3+ macrophages aggravate inflammatory cystitis in diabetes. | Peng Y et al. | β | 2022 | β |
| NLRP3-Mediated Inflammation in Atherosclerosis and Associated Therapeutics. | Lu N et al. | β | 2022 | β |
| Novel role of macrophage TXNIP-mediated CYLD-NRF2-OASL1 axis in stress-induced liver inflammation and cell death. | Zhan Y et al. | β | 2022 | β |
| Nrf2 signaling pathway in trace metal carcinogenesis: A cross-talk between oxidative stress and angiogenesis. | Emami MH et al. | β | 2022 | β |
| Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration. | Lewis LujΓ‘n LM et al. | β | 2022 | β |
| Oridonin attenuates hind limb ischemia-reperfusion injury by modulating Nrf2-mediated oxidative stress and NLRP3-mediated inflammation. | Zhao X et al. | β | 2022 | β |
| Overnutrition-induced gout: An immune response to NLRP3 inflammasome dysregulation by XOD activity increased in quail. | Wu H et al. | β | 2022 | β |
| Overview on Thioredoxin-Interacting Protein (TXNIP): A Potential Target for Diabetes Intervention. | Basnet R et al. | β | 2022 | β |
| Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases. | Shaito A et al. | β | 2022 | β |
| Paeoniflorin ameliorates diabetic liver injury by targeting the TXNIP-mediated NLRP3 inflammasome in db/db mice. | Wang A et al. | β | 2022 | β |
| PARP-1 regulates inflammasome activity by poly-ADP-ribosylation of NLRP3 and interaction with TXNIP in primary macrophages. | Chiu LY et al. | β | 2022 | β |
| Pathways Related to NLRP3 Inflammasome Activation Induced by Gold Nanorods. | Vandebriel RJ et al. | β | 2022 | β |
| Perspectives on the mechanism of pyroptosis after intracerebral hemorrhage. | Song D et al. | β | 2022 | β |
| PGC-1Ξ± inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis. | Nam BY et al. | β | 2022 | β |
| Physiological and modulatory role of thioredoxins in the cellular function. | Xinastle-Castillo LO et al. | β | 2022 | β |
| Plant-derived bioactive compounds regulate the NLRP3 inflammasome to treat NAFLD. | Huang Q et al. | β | 2022 | β |
| Potential therapeutic role of pyroptosis mediated by the NLRP3 inflammasome in type 2 diabetes and its complications. | Li X et al. | β | 2022 | β |
| Programmed cell death in atherosclerosis and vascular calcification. | Li M et al. | β | 2022 | β |
| Prophylactic treatment of <i>Glycyrrhiza glabra</i> mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis | Rizvi ZA et al. | β | 2022 | β |
| Prophylactic treatment of <i>Glycyrrhiza glabra</i> mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis. | Rizvi ZA et al. | β | 2022 | β |
| Protective effects of di-caffeoylquinic acids from Artemisia selengensis Turcz leaves against monosodium urate-induced inflammation via the modulation of NLRP3 inflammasome and Nrf2 signaling pathway in THP-1 macrophages. | Cao W et al. | β | 2022 | β |
| Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications. | Ge Y et al. | β | 2022 | β |
| Pyroptosis in diabetes and diabetic nephropathy. | Cao Z et al. | β | 2022 | β |
| Receptor for Advanced Glycation End-Products Promotes Activation of Alveolar Macrophages through the NLRP3 Inflammasome/TXNIP Axis in Acute Lung Injury. | Lenga Ma Bonda W et al. | β | 2022 | β |
| Redox Homeostasis and Immune Alterations in Coronavirus Disease-19. | Bellanti F et al. | β | 2022 | β |
| Redoxisome and diabetic retinopathy: Pathophysiology and therapeutic interventions. | Sharma I et al. | β | 2022 | β |
| Regenerative Medicine-Based Treatment for Vitiligo: An Overview. | Bellei B et al. | β | 2022 | β |
| Regulation of influenza A virus infection by Lnc-PINK1-2:5. | Pushparaj S et al. | β | 2022 | β |
| Regulation of oxidative stress and inflammatory responses in human retinal pigment epithelial cells. | Harju N | β | 2022 | β |
| Relationship of NLRP3 inflammasome with periodontal, endodontic and related systemic diseases. | Koca-Γnsal RB et al. | β | 2022 | β |
| Relevance of NLRP3 Inflammasome-Related Pathways in the Pathology of Diabetic Wound Healing and Possible Therapeutic Targets. | Ding Y et al. | β | 2022 | β |
| Research progress on related mechanisms of uric acid activating NLRP3 inflammasome in chronic kidney disease. | Wang M et al. | β | 2022 | β |
| Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression. | Cook GM et al. | β | 2022 | β |
| Role of adipose tissue macrophages in obesity-related disorders. | Chakarov S et al. | β | 2022 | β |
| Role of NLRP3 Inflammasome in Myocardial Ischemia-Reperfusion Injury and Ventricular Remodeling. | Shen S et al. | β | 2022 | β |
| Role of Pyroptosis in Intervertebral Disc Degeneration and Its Therapeutic Implications. | Luo J et al. | β | 2022 | β |
| Role of TGF-Beta Signaling in Beta Cell Proliferation and Function in Diabetes. | Wang HL et al. | β | 2022 | β |
| Role of the Inflammasome in Liver Disease. | de Carvalho Ribeiro M et al. | β | 2022 | β |
| ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis. | Zheng D et al. | β | 2022 | β |
| Sex differences exist in adult heart group 2 innate lymphoid cells. | Peng H et al. | β | 2022 | β |
| Signaling pathways involved in paraquat-induced pulmonary toxicity: Molecular mechanisms and potential therapeutic drugs. | Liu X et al. | β | 2022 | β |
| Signaling pathways of chronic kidney diseases, implications for therapeutics. | Yuan Q et al. | β | 2022 | β |
| Slow flow induces endothelial dysfunction by regulating thioredoxin-interacting protein-mediated oxidative metabolism and vascular inflammation. | Wang Y et al. | β | 2022 | β |
| Stem Cell-Derived Islets for Type 2 Diabetes. | Salib A et al. | β | 2022 | β |
| Surfactin Mitigates a High-Fat Diet and Streptozotocin-Induced Type 2 Diabetes through Improving Pancreatic Dysfunction and Inhibiting Inflammatory Response. | Chen X et al. | β | 2022 | β |
| Tandem mass tag-based proteomic profiling revealed potential therapeutic targets and mechanisms of liraglutide for the treatment of impaired glucose tolerance. | Guo Q et al. | β | 2022 | β |
| Targeting AMPK Signaling in the Liver: Implications for Obesity and Type 2 Diabetes Mellitus. | Wang D et al. | β | 2022 | β |
| Targeting NLRP3 Inflammasome With Nrf2 Inducers in Central Nervous System Disorders. | Tastan B et al. | β | 2022 | β |
| Targeting NLRP3-Mediated Neuroinflammation in Alzheimer's Disease Treatment. | Barczuk J et al. | β | 2022 | β |
| Targeting Oxidative Stress and Inflammation in Intervertebral Disc Degeneration: Therapeutic Perspectives of Phytochemicals. | Kang L et al. | β | 2022 | β |
| The biology of pancreatic cancer morphology. | McDonald OG | β | 2022 | β |
| The ER stress sensor inositol-requiring enzyme 1Ξ± in Kupffer cells promotes hepatic ischemia-reperfusion injury. | Cai J et al. | β | 2022 | β |
| The involvement of oxidative stress, neuronal lesions, neurotransmission impairment, and neuroinflammation in acrylamide-induced neurotoxicity in C57/BL6 mice. | Zhao M et al. | β | 2022 | β |
| The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophages. | Duan Y et al. | β | 2022 | β |
| The Mechanism and Regulation of the NLRP3 Inflammasome during Fibrosis. | Artlett CM | β | 2022 | β |
| The Mechanism of the NLRP3 Inflammasome Activation and Pathogenic Implication in the Pathogenesis of Gout. | Kim SK | β | 2022 | β |
| The NLRP3 inflammasome in age-related eye disease: Evidence-based connexin hemichannel therapeutics. | Mugisho OO et al. | β | 2022 | β |
| The Prospective Ameliorative Role of Zinc Oxide Nanoparticles in STZ-Induced Diabetic Nephropathy in Rats: Mechanistic Targeting of Autophagy and Regulating Nrf2/TXNIP/NLRP3 Inflammasome Signaling. | Abd El-Khalik SR et al. | β | 2022 | β |
| The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasome in Liver Disorders. | Lu X et al. | β | 2022 | β |
| The role of mitochondria-associated membranes mediated ROS on NLRP3 inflammasome in cardiovascular diseases. | Zhao J et al. | β | 2022 | β |
| The Role of NLRP3 Inflammasome in IgA Nephropathy. | Wu X et al. | β | 2022 | β |
| The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy. | Liu Y et al. | β | 2022 | β |
| The Role of Oxidative Stress in Intervertebral Disc Degeneration. | Cao G et al. | β | 2022 | β |
| The Role of the Thioredoxin System in Brain Diseases. | BjΓΈrklund G et al. | β | 2022 | β |
| Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders? | Jiang N et al. | β | 2022 | β |
| Thioredoxin-interacting protein deficiency protects against severe acute pancreatitis by suppressing apoptosis signal-regulating kinase 1. | Liu Y et al. | β | 2022 | β |
| Thioredoxin-Interacting Protein in Cancer and Diabetes. | Masutani H | β | 2022 | β |
| Thioredoxin-Interacting Protein (TXNIP) Knockdown Protects against Sepsis-Induced Brain Injury and Cognitive Decline in Mice by Suppressing Oxidative Stress and Neuroinflammation. | Zhang Y et al. | β | 2022 | β |
| Timeβdependent changes in NLRP3 and Nrf2 levels in lipopolysaccharideβinduced acute lung injury. | Dhar R et al. | β | 2022 | β |
| Transcriptomic Profile of Canine DH82 Macrophages Infected by <i>Leishmania infantum</i> Promastigotes with Different Virulence Behavior. | Mas A et al. | β | 2022 | β |
| TXNIP: A Double-Edged Sword in Disease and Therapeutic Outlook. | Pan M et al. | β | 2022 | β |
| TXNIP inhibition in the treatment of diabetes. Verapamil as a novel therapeutic modality in diabetic patients. | Borowiec AM et al. | β | 2022 | β |
| TXNIP inhibits the progression of osteosarcoma through DDIT4-mediated mTORC1 suppression. | Yuan Y et al. | β | 2022 | β |
| TXNIP Participated in NLRP3-Mediated Inflammation in a Rat Model of Cervical Spondylotic Myelopathy. | Liu P et al. | β | 2022 | β |
| Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (<i>S<sub>s</sub></i>)-DS-ONJ. | GΓ³mez-Jaramillo L et al. | β | 2022 | β |
| Urinary Thioredoxin as a Biomarker of Renal Redox Dysregulation and a Companion Diagnostic to Identify Responders to Redox-Modulating Therapeutics. | Kasuno K et al. | β | 2022 | β |
| Zingerone Attenuates Carfilzomib-Induced Cardiotoxicity in Rats through Oxidative Stress and Inflammatory Cytokine Network. | Alam MF et al. | β | 2022 | β |
| Ξ±-Arrestins and Their Functions: From Yeast to Human Health. | Zbieralski K et al. | β | 2022 | β |
| 14-Day Ketone Supplementation Lowers Glucose and Improves Vascular Function in Obesity: A Randomized Crossover Trial. | Walsh JJ et al. | β | 2021 | β |
| Abortive HIV-1 RNA induces pro-IL-1Ξ² maturation via protein kinase PKR and inflammasome activation in humans. | Stunnenberg M et al. | β | 2021 | β |
| Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure. | Hahad O et al. | β | 2021 | β |
| A Combined Drug Treatment That Reduces Mitochondrial Iron and Reactive Oxygen Levels Recovers Insulin Secretion in NAF-1-Deficient Pancreatic Cells. | Karmi O et al. | β | 2021 | β |
| Activation of NLRP3 Inflammasome and Onset of Alzheimer's Disease. | Bai H et al. | β | 2021 | β |
| Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-ΞΊB/NLRP3 inflammation pathway. | Xu X et al. | β | 2021 | β |
| Airborne particulate matter (PM<sub>2.5</sub>) triggers cornea inflammation and pyroptosis via NLRP3 activation. | Niu L et al. | β | 2021 | β |
| AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylation. | Guo X et al. | β | 2021 | β |
| An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes. | Raneros AB et al. | β | 2021 | β |
| A Novel Combination Therapy Using Rosuvastatin and <i>Lactobacillus</i> Combats Dextran Sodium Sulfate-Induced Colitis in High-Fat Diet-Fed Rats by Targeting the TXNIP/NLRP3 Interaction and Influencing Gut Microbiome Composition. | Saber S et al. | β | 2021 | β |
| An overview of disease models for NLRP3 inflammasome over-activation. | Zhang H et al. | β | 2021 | β |
| Anti-inflammatory effects of artesunate on atherosclerosis via miR-16-5p and TXNIP regulation of the NLRP3 inflammasome. | Li B et al. | β | 2021 | β |
| Anti-inflammatory potential of Quercetin in COVID-19 treatment. | Saeedi-Boroujeni A et al. | β | 2021 | β |
| Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells. | Korhonen E et al. | β | 2021 | β |
| An update on the regulatory mechanisms of NLRP3 inflammasome activation. | Paik S et al. | β | 2021 | β |
| Associations between inflammasome-related gene NLRP3 Polymorphisms (rs10754558 and rs35829419) and risk of bladder cancer in a Chinese population. | Xu G et al. | β | 2021 | β |
| ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation. | Zhang T et al. | β | 2021 | β |
| A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans. | Goswamy D et al. | β | 2021 | β |
| Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis. | Lin L et al. | β | 2021 | β |
| A virulent <i>Bacillus cereus</i> strain from deep-sea cold seep induces pyroptosis in a manner that involves NLRP3 inflammasome, JNK pathway, and lysosomal rupture. | Zhao Y et al. | β | 2021 | β |
| Azilsartan Suppressed LPS-Induced Inflammation in U937 Macrophages through Suppressing Oxidative Stress and Inhibiting the TLR2/MyD88 Signal Pathway. | Dong Q et al. | β | 2021 | β |
| Bakuchiol ameliorates cerebral ischemia-reperfusion injury by modulating NLRP3 inflammasome and Nrf2 signaling. | Xu Y et al. | β | 2021 | β |
| Beneficial Effects of Exogenous Ketogenic Supplements on Aging Processes and Age-Related Neurodegenerative Diseases. | KovΓ‘cs Z et al. | β | 2021 | β |
| Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. | Zeng Q et al. | β | 2021 | β |
| Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation. | Wang YL et al. | β | 2021 | β |
| CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys. | Hou Y et al. | β | 2021 | β |
| CD36 Signal Transduction in Metabolic Diseases: Novel Insights and Therapeutic Targeting. | Karunakaran U et al. | β | 2021 | β |
| Chronic intermittent hypoxia-induced mitochondrial dysfunction mediates endothelial injury via the TXNIP/NLRP3/IL-1Ξ² signaling pathway. | Yan YR et al. | β | 2021 | β |
| Chrysin prevents lipopolysaccharide-induced acute lung injury in mice by suppressing the IRE1Ξ±/TXNIP/NLRP3 pathway. | Chen M et al. | β | 2021 | β |
| Crosstalk between Autophagy and Inflammatory Processes in Cancer. | Lee EJ et al. | β | 2021 | β |
| DDX3X deficiency alleviates LPS-induced H9c2 cardiomyocytes pyroptosis by suppressing activation of NLRP3 inflammasome. | Feng D et al. | β | 2021 | β |
| Dieckol Attenuated Glucocorticoid-Induced Muscle Atrophy by Decreasing NLRP3 Inflammasome and Pyroptosis. | Oh S et al. | β | 2021 | β |
| Dietary Curcumin Alleviated Aflatoxin B1-Induced Acute Liver Damage in Ducks by Regulating NLRP3-Caspase-1 Signaling Pathways. | Jin S et al. | β | 2021 | β |
| Discovery of carbon-11 labeled sulfonamide derivative: A PET tracer for imaging brain NLRP3 inflammasome. | Xu Y et al. | β | 2021 | β |
| Disentangling the Molecular Mechanisms of the Antidepressant Activity of Omega-3 Polyunsaturated Fatty Acid: A Comprehensive Review of the Literature. | Kalkman HO et al. | β | 2021 | β |
| Dual regulation of TxNIP by ChREBP and FoxO1 in liver. | Noblet B et al. | β | 2021 | β |
| Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in SjΓΆgren's syndrome. | Barrera MJ et al. | β | 2021 | β |
| Early Predictors in the Onset of Type 2 Diabetes at Different Fasting Blood Glucose Levels. | Xie X et al. | β | 2021 | β |
| Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90. | Xu G et al. | β | 2021 | β |
| Editorial: The Role of Reactive Oxygen Species in Protective Immunity. | Martinvalet D et al. | β | 2021 | β |
| Empagliflozin protects diabetic pancreatic tissue from damage by inhibiting the activation of the NLRP3/caspase-1/GSDMD pathway in pancreatic Ξ² cells: in vitro and in vivo studies. | Liu P et al. | β | 2021 | β |
| Epigenetic regulation of TXNIP-mediated oxidative stress and NLRP3 inflammasome activation contributes to SAHH inhibition-aggravated diabetic nephropathy. | Dai X et al. | β | 2021 | β |
| ER stress associated TXNIP-NLRP3 inflammasome activation in hippocampus of human Alzheimer's disease. | Ismael S et al. | β | 2021 | β |
| Etiological Value of Sterile Inflammation in Preeclampsia: Is It a Non-Infectious Pregnancy Complication? | Banerjee S et al. | β | 2021 | β |
| Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue. | Waldhart AN et al. | β | 2021 | β |
| Exercise training mitigates ER stress and UCP2 deficiency-associated coronary vascular dysfunction in atherosclerosis. | Hong J et al. | β | 2021 | β |
| Exosomes Regulate NLRP3 Inflammasome in Diseases. | Li Z et al. | β | 2021 | β |
| Exploring the mechanism of Yizhi Tongmai decoction in the treatment of vascular dementia through network pharmacology and molecular docking. | Shi H et al. | β | 2021 | β |
| Exposure to epididymal extracellular vesicles enhances immature sperm function and sustains vitality of cryopreserved spermatozoa in the domestic cat model. | Rowlison T et al. | β | 2021 | β |
| Expression of TXNIP is associated with angiogenesis and postoperative relapse of conventional renal cell carcinoma. | Meszaros M et al. | β | 2021 | β |
| Fructose and the Liver. | Muriel P et al. | β | 2021 | β |
| Functions of ROS in Macrophages and Antimicrobial Immunity. | Herb M et al. | β | 2021 | β |
| Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients. | Potje SR et al. | β | 2021 | β |
| HIF-1<i>Ξ±</i>-Mediated miR-623 Regulates Apoptosis and Inflammatory Responses of Nucleus Pulposus Induced by Oxidative Stress via Targeting TXNIP. | Bao X et al. | β | 2021 | β |
| High n-3 fatty acids counteract hyperglycemia-induced insulin resistance in fat-1 mice via pre-adipocyte NLRP3 inflammasome inhibition. | Yu Q et al. | β | 2021 | β |
| How cytosolic compartments play safeguard functions against neuroinflammation and cell death in cerebral ischemia. | Ryan F et al. | β | 2021 | β |
| H<sub>2</sub>S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome. | Cui J et al. | β | 2021 | β |
| <i>Bletilla striata</i> Polysaccharide Promotes Diabetic Wound Healing Through Inhibition of the NLRP3 Inflammasome. | Zhao Y et al. | β | 2021 | β |
| <i>De novo</i> assembly and functional annotation of blood transcriptome of loggerhead turtle, and <i>in silico</i> characterization of peroxiredoxins and thioredoxins. | HernΓ‘ndez-FernΓ‘ndez J et al. | β | 2021 | β |
| Imbalance in thioredoxin system activates NLRP3 inflammasome pathway in epicardial adipose tissue of patients with coronary artery disease. | Shateri H et al. | β | 2021 | β |
| Immunity and Hypertension. | Zhang RM et al. | β | 2021 | β |
| Increased inflammasome activity in subcutaneous adipose tissue of patients with metabolic syndrome. | Pahwa R et al. | β | 2021 | β |
| Inflammasome as an Effective Platform for Fibrosis Therapy. | Chen TT et al. | β | 2021 | β |
| Inflammasome NLRP3 Potentially Links Obesity-Associated Low-Grade Systemic Inflammation and Insulin Resistance with Alzheimer's Disease. | Litwiniuk A et al. | β | 2021 | β |
| Inflammasomes as therapeutic targets in human diseases. | Li Y et al. | β | 2021 | β |
| Inflammation and tumor progression: signaling pathways and targeted intervention. | Zhao H et al. | β | 2021 | β |
| Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment. | Hsu SK et al. | β | 2021 | β |
| Inflammation suppression in doxorubicin-induced cardiotoxicity: natural compounds as therapeutic options. | Yarmohammadi F et al. | β | 2021 | β |
| Inhibition of histone acetyltransferase by naringenin and hesperetin suppresses Txnip expression and protects pancreatic Ξ² cells in diabetic mice. | Wang SW et al. | β | 2021 | β |
| Inhibition of the PERK/TXNIP/NLRP3 Axis by Baicalin Reduces NLRP3 Inflammasome-Mediated Pyroptosis in Macrophages Infected with <i>Mycobacterium tuberculosis</i>. | Fu Y et al. | β | 2021 | β |
| Inhibition of thioredoxin-interacting protein and inflammasome assembly using verapamil mitigates diabetic retinopathy and pancreatic injury. | Eissa LD et al. | β | 2021 | β |
| Inhibitory effect of PPARΞ³ on NLRP3 inflammasome activation. | Yang CC et al. | β | 2021 | β |
| Interleukin-1 in obesity-related low-grade inflammation: From molecular mechanisms to therapeutic strategies. | Ghanbari M et al. | β | 2021 | β |
| Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease. | Ushio-Fukai M et al. | β | 2021 | β |
| Interventional Efects of the Topical of "Sanse Powder" Essential Oils Nanoemulsion on Knee Osteoarthritis in Rats by Targeting the ERS/TXNIP/NLRP3 Signaling Axis. | Liu Z et al. | β | 2021 | β |
| <i>Sonneratia apetala</i> seed oil attenuates potassium oxonate/hypoxanthine-induced hyperuricemia and renal injury in mice. | Chen J et al. | β | 2021 | β |
| Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation. | Lin HC et al. | β | 2021 | β |
| Leptin Induces Apoptotic and Pyroptotic Cell Death via NLRP3 Inflammasome Activation in Rat Hepatocytes. | Baral A et al. | β | 2021 | β |
| Leptin Signaling in the Ovary of Diet-Induced Obese Mice Regulates Activation of NOD-Like Receptor Protein 3 Inflammasome. | Adamowski M et al. | β | 2021 | β |
| Liver injury associated with acute pancreatitis: The current status of clinical evaluation and involved mechanisms. | Liu W et al. | β | 2021 | β |
| LncRNA NEAT1 regulates chondrocyte proliferation and apoptosis via targeting miR-543/PLA2G4A axis. | Xiao P et al. | β | 2021 | β |
| Loganin prevents CXCL12/CXCR4-regulated neuropathic pain via the NLRP3 inflammasome axis in nerve-injured rats. | Cheng KI et al. | β | 2021 | β |
| LuQi Formula Regulates NLRP3 Inflammasome to Relieve Myocardial-Infarction-Induced Cardiac Remodeling in Mice. | Zhang X et al. | β | 2021 | β |
| Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-<i>ΞΊ</i>B Pathways. | Zhang H et al. | β | 2021 | β |
| Luteolin inhibits NLRP3 inflammasome activation via blocking ASC oligomerization. | Lee MN et al. | β | 2021 | β |
| Lysosome Function in Cardiovascular Diseases. | Bhat OM et al. | β | 2021 | β |
| Medicinal plants and bioactive natural products as inhibitors of NLRP3 inflammasome. | Bagherniya M et al. | β | 2021 | β |
| Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway. | Wu Y et al. | β | 2021 | β |
| Mesenchymal Stem Cell-Mediated Mitochondrial Transfer: a Therapeutic Approach for Ischemic Stroke. | Lu M et al. | β | 2021 | β |
| miR-200a-3p Attenuates Coronary Microembolization-Induced Myocardial Injury in Rats by Inhibiting TXNIP/NLRP3-Mediated Cardiomyocyte Pyroptosis. | Chen ZQ et al. | β | 2021 | β |
| Mitochondria-Endoplasmic Reticulum Crosstalk in Parkinson's Disease: The Role of Brain Renin Angiotensin System Components. | Sunanda T et al. | β | 2021 | β |
| Mitochondria Lead the Way: Mitochondrial Dynamics and Function in Cellular Movements in Development and Disease. | Madan S et al. | β | 2021 | β |
| Modulation of Macrophage Activity by Pulsed Electromagnetic Fields in the Context of Fracture Healing. | Chen Y et al. | β | 2021 | β |
| Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm. | Suslov AV et al. | β | 2021 | β |
| MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment. | Lu Y et al. | β | 2021 | β |
| Neuregulin-1 alleviate oxidative stress and mitigate inflammation by suppressing NOX4 and NLRP3/caspase-1 in myocardial ischaemia-reperfusion injury. | Wang F et al. | β | 2021 | β |
| New Insights into Pathomechanisms and Treatment Possibilities for Lung Silicosis. | Adamcakova J et al. | β | 2021 | β |
| Nicotine exacerbates atherosclerosis through a macrophage-mediated endothelial injury pathway. | Mao C et al. | β | 2021 | β |
| Nlrp3 Deficiency Alleviates Angiotensin II-Induced Cardiomyopathy by Inhibiting Mitochondrial Dysfunction. | Chen Y et al. | β | 2021 | β |
| Nlrp3 Increases the Host's Susceptibility to Tularemia. | Suresh RV et al. | β | 2021 | β |
| NLRP3 inflammasome and IL-1Ξ² pathway in type 2 diabetes and atherosclerosis: Friend or foe? | Chen X et al. | β | 2021 | β |
| NLRP3 Inflammasome as a Common Denominator of Atherosclerosis and Abdominal Aortic Aneurysm. | Takahashi M | β | 2021 | β |
| NLRP3 Inflammasome in Metabolic-Associated Kidney Diseases: An Update. | Xiong W et al. | β | 2021 | β |
| NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle. | Jorquera G et al. | β | 2021 | β |
| Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases. | Wang W et al. | β | 2021 | β |
| Non-coding RNAs: The key regulators in NLRP3 inflammasome-mediated inflammatory diseases. | Feng X et al. | β | 2021 | β |
| Nuclear Receptors in the Control of the NLRP3 Inflammasome Pathway. | Duez H et al. | β | 2021 | β |
| Oxidative Stress in Cancer Cell Metabolism. | Arfin S et al. | β | 2021 | β |
| Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction. | Dutta S et al. | β | 2021 | β |
| P2X7 receptor and the NLRP3 inflammasome: Partners in crime. | Pelegrin P | β | 2021 | β |
| Parabens disrupt non-canonical inflammasome activation. | Ahn H et al. | β | 2021 | β |
| Pathophysiological roles of chronic low-grade inflammation mediators in polycystic ovary syndrome. | Rostamtabar M et al. | β | 2021 | β |
| Paving the Road Toward Exploiting the Therapeutic Effects of Ginsenosides: An Emphasis on Autophagy and Endoplasmic Reticulum Stress. | Ashrafizadeh M et al. | β | 2021 | β |
| PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway. | Samidurai M et al. | β | 2021 | β |
| Potential Role of Antioxidant and Anti-Inflammatory Therapies to Prevent Severe SARS-Cov-2 Complications. | Fratta Pasini AM et al. | β | 2021 | β |
| Potential role of mitochondria in synoviocytes. | Li M et al. | β | 2021 | β |
| Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-ΞΊB signaling and NLRP3 inflammasome activation. | Qin W et al. | β | 2021 | β |
| Priming of NLRP3 inflammasome activation by Msn kinase MINK1 in macrophages. | Zhu K et al. | β | 2021 | β |
| Protective effect of dimethyl itaconate against fibroblast-myofibroblast differentiation during pulmonary fibrosis by inhibiting TXNIP. | Han YY et al. | β | 2021 | β |
| Protective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice. | Zhao X et al. | β | 2021 | β |
| Pyroptosis: A New Insight Into Eye Disease Therapy. | Zhang Y et al. | β | 2021 | β |
| Pyroptosis is a critical immune-inflammatory response involved in atherosclerosis. | He X et al. | β | 2021 | β |
| Pyroptosis, metabolism, and tumor immune microenvironment. | Du T et al. | β | 2021 | β |
| Reactive Oxygen Species in Macrophages: Sources and Targets. | Canton M et al. | β | 2021 | β |
| Redox and Inflammatory Signaling, the Unfolded Protein Response, and the Pathogenesis of Pulmonary Hypertension. | Katseff A et al. | β | 2021 | β |
| Redox Homeostasis in Pancreatic Ξ²-Cells: From Development to Failure. | BenΓ‘kovΓ‘ Ε et al. | β | 2021 | β |
| Redox regulation of immunometabolism. | Muri J et al. | β | 2021 | β |
| Regulation and functions of NLRP3 inflammasome in cardiac fibrosis: Current knowledge and clinical significance. | Zhang X et al. | β | 2021 | β |
| Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury. | Zou J et al. | β | 2021 | β |
| Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke. | Xu Q et al. | β | 2021 | β |
| Research Progress of Mitochondrial Mechanism in NLRP3 Inflammasome Activation and Exercise Regulation of NLRP3 Inflammasome. | Zhang T et al. | β | 2021 | β |
| Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes. | Fan W et al. | β | 2021 | β |
| Role of ASM/Cer/TXNIP signaling module in the NLRP3 inflammasome activation. | Jiang J et al. | β | 2021 | β |
| Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders. | Wani K et al. | β | 2021 | β |
| Role of Pyroptosis in Diabetes and Its Therapeutic Implications. | Mamun AA et al. | β | 2021 | β |
| Role of pyroptosis in diabetic retinopathy and its therapeutic implications. | Al Mamun A et al. | β | 2021 | β |
| Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook. | Qayyum N et al. | β | 2021 | β |
| Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases. | Li P et al. | β | 2021 | β |
| Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis. | Zheng T et al. | β | 2021 | β |
| Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation. | Ma W et al. | β | 2021 | β |
| Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation. | Tapia-AbellΓ‘n A et al. | β | 2021 | β |
| Signaling pathways and intervention therapies in sepsis. | Zhang YY et al. | β | 2021 | β |
| Specific NLRP3 inflammasome inhibitors: promising therapeutic agents for inflammatory diseases. | Vong CT et al. | β | 2021 | β |
| Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis. | Jiang C et al. | β | 2021 | β |
| Statins Directly Influence the Polarization of Adipose Tissue Macrophages: A Role in Chronic Inflammation. | Kauerova S et al. | β | 2021 | β |
| Statistical Integration of 'Omics Data Increases Biological Knowledge Extracted from Metabolomics Data: Application to Intestinal Exposure to the Mycotoxin Deoxynivalenol. | Tremblay-Franco M et al. | β | 2021 | β |
| Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice. | Li A et al. | β | 2021 | β |
| Sulfonylureas for Treatment of Periodontitis-Diabetes Comorbidity-Related Complications: Killing Two Birds With One Stone. | Yang L et al. | β | 2021 | β |
| Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation. | Yue H et al. | β | 2021 | β |
| Targeting NLRP3 Inflammasome in the Treatment Of Diabetes and Diabetic Complications: Role of Natural Compounds from Herbal Medicine. | Bai Y et al. | β | 2021 | β |
| The ASC Speck and NLRP3 Inflammasome Function Are Spatially and Temporally Distinct. | Nagar A et al. | β | 2021 | β |
| The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3. | Tang T et al. | β | 2021 | β |
| The Emerging Role of Metabolism in Brain-Heart Axis: New Challenge for the Therapy and Prevention of Alzheimer Disease. May Thioredoxin Interacting Protein (TXNIP) Play a Role? | Perrone L et al. | β | 2021 | β |
| The Emerging Role of TXNIP in Ischemic and Cardiovascular Diseases; A Novel Marker and Therapeutic Target. | Domingues A et al. | β | 2021 | β |
| The Essential Oil of <i>Artemisia argyi</i> H.LΓ©v. and Vaniot Attenuates NLRP3 Inflammasome Activation in THP-1 Cells. | Chen P et al. | β | 2021 | β |
| The Good and Bad of Nrf2: An Update in Cancer and New Perspectives in COVID-19. | Emanuele S et al. | β | 2021 | β |
| The molecular mechanism and functional diversity of UPR signaling sensor IRE1. | Bashir S et al. | β | 2021 | β |
| The NLRP3 inflammasome: an emerging therapeutic target for chronic pain. | Chen R et al. | β | 2021 | β |
| The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury. | Ismael S et al. | β | 2021 | β |
| The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-ΞΊB pathway. | Zhang P et al. | β | 2021 | β |
| The Purinergic P2X7 Receptor-NLRP3 Inflammasome Pathway: A New Target in Alcoholic Liver Disease? | Le DarΓ© B et al. | β | 2021 | β |
| Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis. | Shao S et al. | β | 2021 | β |
| The resilient phenotype elicited by ketamine against inflammatory stressors-induced depressive-like behavior is associated with NLRP3-driven signaling pathway. | Camargo A et al. | β | 2021 | β |
| The Role of AhR in the Hallmarks of Brain Aging: Friend and Foe. | Ojo ES et al. | β | 2021 | β |
| The Role of Immune Cells in Oxi-Inflamm-Aging. | MartΓnez de Toda I et al. | β | 2021 | β |
| The Role of Melatonin on NLRP3 Inflammasome Activation in Diseases. | Arioz BI et al. | β | 2021 | β |
| The Role of NLRP3 Inflammasome in Lupus Nephritis. | Oliveira CB et al. | β | 2021 | β |
| The Role of Oxidative Stress in Pancreatic Ξ² Cell Dysfunction in Diabetes. | Eguchi N et al. | β | 2021 | β |
| The role of traditional Chinese medicine in the treatment of cognitive dysfunction in type 2 diabetes. | Meng J et al. | β | 2021 | β |
| The Signaling Pathways Regulating NLRP3 Inflammasome Activation. | Chen MY et al. | β | 2021 | β |
| The Subtle Role of Para-inflammation in Modulating the Progression of Dry Eye Disease. | Rolando M et al. | β | 2021 | β |
| The Ξ±-arrestin family of ubiquitin ligase adaptors links metabolism with selective endocytosis. | Kahlhofer J et al. | β | 2021 | β |
| Thioredoxin interacting protein regulates age-associated neuroinflammation. | Ismael S et al. | β | 2021 | β |
| Tranilast: a potential anti-Inflammatory and NLRP3 inflammasome inhibitor drug for COVID-19. | Saeedi-Boroujeni A et al. | β | 2021 | β |
| Ulinastatin inhibits NLRP3-induced apoptosis in a PD cell model. | Lin Y et al. | β | 2021 | β |
| Vascular and Cardiac Oxidative Stress and Inflammation as Targets for Cardioprotection. | Daiber A et al. | β | 2021 | β |
| Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway. | Han M et al. | β | 2021 | β |
| Walking down Skeletal Muscle Lane: From Inflammasome to Disease. | Dubuisson N et al. | β | 2021 | β |
| ADAM17 cytoplasmic domain modulates Thioredoxin-1 conformation and activity. | E Costa RAP et al. | β | 2020 | β |
| Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/GSK-3Ξ². | Liu H et al. | β | 2020 | β |
| Adipose tissue, immune aging, and cellular senescence. | Frasca D et al. | β | 2020 | β |
| Administration of kynurenic acid reduces hyperlipidemia-induced inflammation and insulin resistance in skeletal muscle and adipocytes. | Jung TW et al. | β | 2020 | β |
| Age-related factors that affect B cell responses to vaccination in mice and humans. | Frasca D et al. | β | 2020 | β |
| All-Trans Retinoic Acid Enhances both the Signaling for Priming and the Glycolysis for Activation of NLRP3 Inflammasome in Human Macrophage. | Alatshan A et al. | β | 2020 | β |
| Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease. | MarginΔ D et al. | β | 2020 | β |
| A Role for Endoplasmic Reticulum Stress in Intracerebral Hemorrhage. | Mohammed Thangameeran SI et al. | β | 2020 | β |
| Arrestin domain containing 3 promotes Helicobacter pylori-associated gastritis by regulating protease-activated receptor 1. | Liu YG et al. | β | 2020 | β |
| Association between Nod-like receptor protein 3 inflammasome and gouty nephropathy. | Zhang YZ et al. | β | 2020 | β |
| Association between Proinflammatory Markers, Leukocyte-Endothelium Interactions, and Carotid Intima-Media Thickness in Type 2 Diabetes: Role of Glycemic Control. | de MaraΓ±Γ³n AM et al. | β | 2020 | β |
| Association of smoking habits with TXNIP DNA methylation levels in leukocytes among general Japanese population. | Maeda K et al. | β | 2020 | β |
| Autophagy, One of the Main Steps in Periodontitis Pathogenesis and Evolution. | Greabu M et al. | β | 2020 | β |
| Bakuchiol Attenuates Oxidative Stress and Neuron Damage by Regulating Trx1/TXNIP and the Phosphorylation of AMPK After Subarachnoid Hemorrhage in Mice. | Liu H et al. | β | 2020 | β |
| Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis <i>via</i> the ROS/TXNIP Axis. | Mai W et al. | β | 2020 | β |
| Beta Cell Physiological Dynamics and Dysfunctional Transitions in Response to Islet Inflammation in Obesity and Diabetes. | Cerf ME | β | 2020 | β |
| Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure. | Zhou B et al. | β | 2020 | β |
| Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction. | Chevriaux A et al. | β | 2020 | β |
| Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration. | Casals E et al. | β | 2020 | β |
| Corticosteroids alleviate lipopolysaccharide-induced inflammation and lung injury via inhibiting NLRP3-inflammasome activation. | Yang JW et al. | β | 2020 | β |
| Crosstalk between ER stress, NLRP3 inflammasome, and inflammation. | Li W et al. | β | 2020 | β |
| Curcumin: an inflammasome silencer. | Hasanzadeh S et al. | β | 2020 | β |
| Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome. | Shrivastava G et al. | β | 2020 | β |
| Dimethyl fumarate ameliorates diabetes-associated vascular complications through ROS-TXNIP-NLRP3 inflammasome pathway. | Amin FM et al. | β | 2020 | β |
| Dopamine D1 receptor agonist A68930 attenuates acute kidney injury by inhibiting NLRP3 inflammasome activation. | Cao JY et al. | β | 2020 | β |
| Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and PGC1Ξ± Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link. | Ryu JY et al. | β | 2020 | β |
| Effects of air pollution particles (ultrafine and fine particulate matter) on mitochondrial function and oxidative stress - Implications for cardiovascular and neurodegenerative diseases. | Daiber A et al. | β | 2020 | β |
| Endoplasmic reticulum stress and oxidative stress contribute to neuronal pyroptosis caused by cerebral venous sinus thrombosis in rats: Involvement of TXNIP/peroxynitrite-NLRP3 inflammasome activation. | Ding R et al. | β | 2020 | β |
| Endoplasmic reticulum stress related factor IRE1Ξ± regulates TXNIP/NLRP3-mediated pyroptosis in diabetic nephropathy. | Ke R et al. | β | 2020 | β |
| Endothelial Damage, Inflammation and Immunity in Chronic Kidney Disease. | Diaz-Ricart M et al. | β | 2020 | β |
| Enhanced Keap1-Nrf2/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1/JNK and Txnip/NLRP3 inflammasome activation. | Lv H et al. | β | 2020 | β |
| Ethanol Augments Monosodium Urate-Induced NLRP3 Inflammasome Activation via Regulation of AhR and TXNIP in Human Macrophages. | Kim SK et al. | β | 2020 | β |
| Ethnopharmacology of Fruit Plants: A Literature Review on the Toxicological, Phytochemical, Cultural Aspects, and a Mechanistic Approach to the Pharmacological Effects of Four Widely Used Species. | de Carvalho AT et al. | β | 2020 | β |
| Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice. | Wang D et al. | β | 2020 | β |
| Focus on the Role of NLRP3 Inflammasome in Diseases. | Fusco R et al. | β | 2020 | β |
| From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases. | Zhao P et al. | β | 2020 | β |
| Galectin-3 in Inflammasome Activation and Primary Biliary Cholangitis Development. | Arsenijevic A et al. | β | 2020 | β |
| Gap junctions amplify TRPV4 activation-initiated cell injury via modification of intracellular Ca<sup>2+</sup> and Ca<sup>2+</sup>-dependent regulation of TXNIP. | Zhang X et al. | β | 2020 | β |
| Good Cop, Bad Cop: The Opposing Effects of Macrophage Activation State on Maintaining or Damaging Functional Ξ²-Cell Mass. | Jensen DM et al. | β | 2020 | β |
| Gout: a disease involved with complicated immunoinflammatory responses: a narrative review. | Wu M et al. | β | 2020 | β |
| Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1Ξ² activation on macrophages. | Renaudin F et al. | β | 2020 | β |
| Gut-Liver Axis and Inflammasome Activation in Cholangiocyte Pathophysiology. | Maroni L et al. | β | 2020 | β |
| Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes. | Scheithauer TPM et al. | β | 2020 | β |
| GW0742 activates miR-17-5p and inhibits TXNIP/NLRP3-mediated inflammation after hypoxic-ischaemic injury in rats and in PC12 cells. | Gamdzyk M et al. | β | 2020 | β |
| High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARΞ±: a new model for steatohepatitis-associated fibrosis. | Chen X et al. | β | 2020 | β |
| High Glucose-Aggravated Hepatic Insulin Resistance: Role of the NLRP3 Inflammasome in Kupffer Cells. | Zheng T et al. | β | 2020 | β |
| HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2. | Yang X et al. | β | 2020 | β |
| Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action. | Thielen LA et al. | β | 2020 | β |
| Immunoregulation of the decidualization program: focus on the endoplasmic reticulum stress. | Soczewski E et al. | β | 2020 | β |
| Inflammasome activation and regulation: toward a better understanding of complex mechanisms. | Zheng D et al. | β | 2020 | β |
| Inflammasome activation in podocytes: a new mechanism of glomerular diseases. | Xiong W et al. | β | 2020 | β |
| Inhibition of NLRP3 Inflammasome: A Prospective Target for the Treatment of Ischemic Stroke. | Feng YS et al. | β | 2020 | β |
| Inhibition of NLRP3 inflammasome by MCC950 improves the metabolic outcome of islet transplantation by suppressing IL-1Ξ² and islet cellular death. | Matsuoka T et al. | β | 2020 | β |
| Interplay Between NLRP3 Inflammasome and Autophagy. | Biasizzo M et al. | β | 2020 | β |
| <i>Tamarix chinensis Lour</i> inhibits chronic ethanol-induced liver injury in mice. | Wang ZD et al. | β | 2020 | β |
| Koumine Suppresses IL-1Ξ² Secretion and Attenuates Inflammation Associated With Blocking ROS/NF-ΞΊB/NLRP3 Axis in Macrophages. | Luo Y et al. | β | 2020 | β |
| LDL, LDL receptors, and PCSK9 as modulators of the risk for type 2 diabetes: a focus on white adipose tissue. | Faraj M | β | 2020 | β |
| Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes. | Santos-Bezerra DP et al. | β | 2020 | β |
| Lipids, inflammasomes, metabolism, and disease. | Anand PK | β | 2020 | β |
| Liraglutide protects against high-fat diet-induced kidney injury by ameliorating apoptosis. | Liang R et al. | β | 2020 | β |
| Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation. | Cheng YC et al. | β | 2020 | β |
| Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease. | Zhang Y et al. | β | 2020 | β |
| Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging. | FernΓ‘ndez-Ortiz M et al. | β | 2020 | β |
| Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection. | Tucey TM et al. | β | 2020 | β |
| Metabolism-Associated Molecular Patterns (MAMPs). | Wang X et al. | β | 2020 | β |
| Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway. | Jia Y et al. | β | 2020 | β |
| Microbiota-Mitochondria Inter-Talk: A Potential Therapeutic Strategy in Obesity and Type 2 Diabetes. | Vezza T et al. | β | 2020 | β |
| miR-29c-3p inhibits microglial NLRP3 inflammasome activation by targeting NFAT5 in Parkinson's disease. | Wang R et al. | β | 2020 | β |
| Mitochondrial Dysfunction and Inflammaging in Heart Failure: Novel Roles of CYP-Derived Epoxylipids. | Keshavarz-Bahaghighat H et al. | β | 2020 | β |
| Mitochondrial-targeted ubiquinone alleviates concanavalin A-induced hepatitis via immune modulation. | Desta YT et al. | β | 2020 | β |
| Mitochondrial Transfer as a Therapeutic Strategy Against Ischemic Stroke. | Chen W et al. | β | 2020 | β |
| Molecular Mechanisms That Link Oxidative Stress, Inflammation, and Fibrosis in the Liver. | Ramos-Tovar E et al. | β | 2020 | β |
| Neuroinflammation Mediated by NLRP3 Inflammasome After Intracerebral Hemorrhage and Potential Therapeutic Targets. | Xiao L et al. | β | 2020 | β |
| Neuroinflammation, oxidative stress and their interplay in neuropathic pain: Focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential therapeutic strategies. | Teixeira-Santos L et al. | β | 2020 | β |
| New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease. | Lin J et al. | β | 2020 | β |
| Nitroxyl: A Novel Strategy to Circumvent Diabetes Associated Impairments in Nitric Oxide Signaling. | Velagic A et al. | β | 2020 | β |
| NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis. | Liu Y et al. | β | 2020 | β |
| NLRP3 Inflammasome Biomarker-Could Be the New Tool for Improved Cardiometabolic Syndrome Outcome. | Suceveanu AI et al. | β | 2020 | β |
| NLRP3 inflammasome drives inflammation in high fructose fed diabetic rat liver: Effect of resveratrol and metformin. | Rai RC et al. | β | 2020 | β |
| NLRP3 Inflammasome in Inflammation and Metabolism: Identifying Novel Roles in Postburn Adipose Dysfunction. | Vinaik R et al. | β | 2020 | β |
| NLRP3 Inflammasome is Activated in Rat Pancreatic Islets by Transplantation and Hypoxia. | Lavallard V et al. | β | 2020 | β |
| NLRP3 Sensing of Diverse Inflammatory Stimuli Requires Distinct Structural Features. | Rahman T et al. | β | 2020 | β |
| Nonesterified free fatty acids enhance the inflammatory response in renal tubules by inducing extracellular ATP release. | Sun H et al. | β | 2020 | β |
| Nutraceutical Strategies for Suppressing NLRP3 Inflammasome Activation: Pertinence to the Management of COVID-19 and Beyond. | McCarty MF et al. | β | 2020 | β |
| Nutrient Sensor mTOR and OGT: Orchestrators of Organelle Homeostasis in Pancreatic <i>Ξ²</i>-Cells. | Esch N et al. | β | 2020 | β |
| Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications. | Wondmkun YT | β | 2020 | β |
| Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression. | BeltrΓ‘n-GarcΓa J et al. | β | 2020 | β |
| Paracrine regulation and improvement of Ξ²-cell function by thioredoxin. | Hanschmann EM et al. | β | 2020 | β |
| PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL-1Ξ² Secretion. | Le S et al. | β | 2020 | β |
| Polymorphism of nucleotide binding domain-like receptor protein 3 (NLRP3) increases susceptibility of total urinary arsenic to renal cell carcinoma. | Chung CJ et al. | β | 2020 | β |
| Pre-Existing Cytokine and NLRP3 Inflammasome Activation and Increased Vascular Permeability in Diabetes: A Possible Fatal Link With Worst COVID-19 Infection Outcomes? | Lambadiari V et al. | β | 2020 | β |
| Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice. | Zhu Y et al. | β | 2020 | β |
| RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly. | Duan Y et al. | β | 2020 | β |
| Reactive Oxygen Species Interact With NLRP3 Inflammasomes and Are Involved in the Inflammation of Sepsis: From Mechanism to Treatment of Progression. | Zhao S et al. | β | 2020 | β |
| Real-time diagnosis of reactive oxygen species (ROS) in fresh sputum by electrochemical tracing; correlation between COVID-19 and viral-induced ROS in lung/respiratory epithelium during this pandemic. | Miripour ZS et al. | β | 2020 | β |
| Recent advances in the NEK7-licensed NLRP3 inflammasome activation: Mechanisms, role in diseases and related inhibitors. | Zhao N et al. | β | 2020 | β |
| "Repair Me if You Can": Membrane Damage, Response, and Control from the Viral Perspective. | Daussy CF et al. | β | 2020 | β |
| Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? | Klein P et al. | β | 2020 | β |
| Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development. | Ambati J et al. | β | 2020 | β |
| Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers. | Chen Y et al. | β | 2020 | β |
| Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies. | Daiber A et al. | β | 2020 | β |
| RIPK2 Dictates Insulin Responses to Tyrosine Kinase Inhibitors in Obese Male Mice. | Duggan BM et al. | β | 2020 | β |
| Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases. | Molla MD et al. | β | 2020 | β |
| Rosmarinic acid inhibits oxLDL-induced inflammasome activation under high-glucose conditions through downregulating the p38-FOXO1-TXNIP pathway. | Nyandwi JB et al. | β | 2020 | β |
| Structure and Function of HECT E3 Ubiquitin Ligases and their Role in Oxidative Stress. | Qian H et al. | β | 2020 | β |
| Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects <i>via</i> the TXNIP-NLRP3-GSDMD Axis. | Li N et al. | β | 2020 | β |
| TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation. | Shi Y et al. | β | 2020 | β |
| The Causal Role of Mitochondrial Dynamics in Regulating Innate Immunity in Diabetes. | Chang YH et al. | β | 2020 | β |
| The Inflammasome in Chronic Complications of Diabetes and Related Metabolic Disorders. | Menini S et al. | β | 2020 | β |
| The interrupted cross-talk of inflammatory and oxidative stress trajectories signifies the effect of artesunate against hepatic ischemia/reperfusion-induced inflammasomopathy. | Ghoneim ME et al. | β | 2020 | β |
| The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease. | Wilson RB et al. | β | 2020 | β |
| The NLRP3 Inflammasome and Its Role in T1DM. | Sun X et al. | β | 2020 | β |
| The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process. | Sebastian-Valverde M et al. | β | 2020 | β |
| The Nlrp3 inflammasome as a "rising star" in studies of normal and malignant hematopoiesis. | Ratajczak MZ et al. | β | 2020 | β |
| The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging. | Meyers AK et al. | β | 2020 | β |
| The Protective Effects of Peroxisome Proliferator-Activated Receptor Gamma in Cerebral Ischemia-Reperfusion Injury. | Ding Y et al. | β | 2020 | β |
| The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders. | Missiroli S et al. | β | 2020 | β |
| The Role of NLRP3 Inflammasome in Radiation-Induced Cardiovascular Injury. | Huang S et al. | β | 2020 | β |
| Thioredoxin Interacting Protein (TXNIP) Is Differentially Expressed in Human Tumor Samples but Is Absent in Human Tumor Cell Line Xenografts: Implications for Its Use as an Immunosurveillance Marker. | SchrΓΆder J et al. | β | 2020 | β |
| Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases. | Tsubaki H et al. | β | 2020 | β |
| Transcriptomic Analysis Reveals the Protection of Astragaloside IV against Diabetic Nephropathy by Modulating Inflammation. | Zhang Y et al. | β | 2020 | β |
| TXNIP induces growth arrest and enhances ABT263-induced apoptosis in mixed-lineage leukemia-rearranged acute myeloid leukemia cells. | Noura M et al. | β | 2020 | β |
| TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis. | Yoshihara E | β | 2020 | β |
| Usefulness of Interleukin-1 Receptor Antagonists in Patients With Recurrent Pericarditis. | Khayata M et al. | β | 2020 | β |
| VIP conditions human endometrial receptivity by privileging endoplasmic reticulum stress through ATF6Ξ± pathway. | Soczewski E et al. | β | 2020 | β |