The inflammasome: pathways linking psychological stress, depression, and systemic illnesses.

paper Cited Public

Authors: Iwata, Masaaki; Ota, Kristie T; Duman, Ronald S
Year: 2013
Journal: Brain, behavior, and immunity
PMID: 23261775
DOI: 10.1016/j.bbi.2012.12.008
PMCID: PMC4426992

Fig. 1

Danger signals and host defense mechanisms. Danger signals are detected via pattern recognition receptors (PRRs) to prepare defensive responses. PRRs can be classified into two main groups, membrane associated and cytosolic. NOD-like receptors (NLRs) are cytosolic PRRs, and can detect diverse ligands including ATP, fatty acids and amyloid β. NLRP3, one of the best characterized NLRs, forms large multiprotein complexes termed inflammasomes. However, the mechanism by which the NLRP3 inflammasome detects such diverse ligands is unclear. Shown in this figure is the pathway for regulation of IL-1β. Danger signals such as PAMPs are detected by TLRs and induce the synthesis of pro-IL-1β. Pro-IL-1β is processed by the oligomerized NLRP3 complex leading to secretion of IL-1β. Although psychological stress is known to increase plasma levels of IL-1β, the mechanism by which psychological stress is detected by the innate immune system is not known. Abbreviations: AIM, absent in melanoma; DAI, DNA-dependent activator of interferon (IFN)-regulatory factors; IPAF, ICE-protease activating factor; NLRP, NLR family, pyrin domain-containing; NOD, nucleotide-binding oligomerization domain.

LLM interpretation

This figure is a schematic diagram illustrating the pathway from danger signals to the inflammatory response. It shows physical and psychological stress triggering host defense mechanisms via membrane-associated PRRs (e.g., TLRs, CLRs) and cytosolic PRRs (e.g., NLRs, RLRs) within a microglia or macrophage. The diagram depicts a two-step process where PRR activation leads to the synthesis of pro-IL-1β and its subsequent processing into secreted IL-1β, alongside the production of IL-6 and TNFα.

Fig. 2

Inflammasome subtypes and activation of NLRP3. A. There are four cytosolic pattern recognition receptors that can form inflammasomes that subsequently activate caspase-1 and produce IL-1β. B. The NLRP3 inflammasome undergoes autoinhibition by binding of the LRR domain to the NACHT domain, resulting in blockade of oligomerization and ASC binding. Stimulation relieves this inhibition and enables NLRP3 to bind with pro-caspase-1 through the adaptor protein ASC. Pro-caspase-1 is then cleaved, and the activated caspase-1 cleaves pro-IL-1β, resulting in the release of IL-1β. Interestingly, the NLRP3 inflammasome can detect not only PAMPs, but also DAMPs, which include endogenous danger signals such as ATP. Extracellular ATP binds to the P2X7 receptor ionophore, causing K + efflux, which leads to oligomerization NLRP3. ATP may be associated with stimuli that can cause damage to cells, such as high levels of the excitatory neurotransmitter glutamate, which can cause excitotoxicity. Abbreviations: ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain; CARD, caspase-recruitment domain; FIIND, domain with function to find; LRRs, leucine-rich repeats; NACHT, nucleotide-binding oligomerizetion; NLRP3, NLR family, pyrin domain-containing 3; PYD, Pyrin domain.

LLM interpretation

This figure consists of two diagrams illustrating inflammasome activation. Panel A shows the domain structures of four cytosolic pattern recognition receptors (NLRP1, NLRP3, NLRC4, and AIM2) and the additional components required to activate caspase-1. Panel B is a schematic of a microglia cell depicting the transition of NLRP3 from an inactive, autoinhibited state to an active inflammasome complex triggered by stimuli such as ATP via the P2X7 receptor, leading to the cleavage of pro-IL-1β and the release of IL-1β.

Fig. 3

Pro inflammatory cytokines activate the HPA axis. Hypothalamic CRH stimulates the pituitary, which in turn releases ACTH, leading to stimulation of the adrenal cortex. Released glucocorticoid provides negative feedback on the HPA axis via the hypothalamus and pituitary, as well as hippocampus. Glucocorticoids also suppress pro-inflammatory cytokines under normal conditions, although paradoxically cytokine levels remain high in depressed patients. Cytokine-activation of the HPA axis in the presence of elevated glucocorticoid levels could result from disruption of HPA axis homeostatic mechanisms: that is, inflammatory cytokines activate each step of the HPA axis, including the hypothalamus, pituitary and adrenal cortex. This occurs at the same time that cytokines disrupt glucocorticoid receptor-mediated negative feedback (see text). In this model, inflammatory cytokines in the brain are directly activated by stress. Also, brain pro-inflammatory cytokines can reciprocally affect peripheral cytokines, which can activate the HPA axis and also influence other brain regions via several possible mechanisms (see text). Increased pro-inflammatory cytokines in both brain and periphery disturb negative feedback by glucocorticoids. Abbreviations: ACTH, adrenocorticotropic hormone; CORT, corticosterone; CRH, corticotropin-releasing hormone.

LLM interpretation

This is a schematic diagram illustrating the interaction between pro-inflammatory cytokines and the hypothalamic-pituitary-adrenal (HPA) axis. The figure shows a pathway where stress triggers pro-inflammatory cytokines (IL-1$\beta$, IL-6, TNF$\alpha$) in the brain and periphery, which stimulate the hypothalamus (CRH), pituitary (ACTH), and adrenal cortex to release corticosterone (CORT). Blue inhibitory lines indicate that CORT normally provides negative feedback to the hypothalamus and pituitary and suppresses cytokines, while green arrows denote a reciprocal interaction between brain and peripheral cytokines.

Fig. 4

NLRP3 inflammasome is a central mediator of depression and comorbid disease. Top panel: (A) Psychological stress could cause activation the NLRP3 inflammasome, which may lead to release of IL-1β and the development of depression. Danger substances also activate the NLRP3 inflammasome and contribute to the pathology of several comorbid diseases. Thus, the NLRP3 could be a central mediator of both psychological and systemic diseases. In support of this, it is well known that psychological stress can affect systemic, peripheral diseases, and these diseases frequently accompany depression. Bottom panel: (B) depression is caused by psychological stress via the NLRP3 inflammasome; (C) systemic diseases can be caused by danger substances via the NLRP3 inflammasome; (D) the NLRP3 inflammasome may also explain how psychological stress can contribute to the development of systemic diseases (psychosomatic disorder); and (E) how intra- and extra- cellular danger substances can lead to the development of depression (somato-psycho disorder). Taken together, it is hypothesized that NLRP3 serves as a bridge between psychological stress and depression, as well as bidirectional pathway between depression and systemic comorbid illnesses.

LLM interpretation

This figure consists of a series of conceptual diagrams illustrating the role of the NLRP3 inflammasome as a mediator between various triggers and diseases. Panel A shows a central model where psychological stress and danger substances (e.g., hyperglycemia, allergens) activate the NLRP3 inflammasome, which then leads to depression and systemic diseases (e.g., diabetes, asthma). Panels B through E provide simplified flowcharts depicting specific pathways: psychological stress to depression (B), danger substances to systemic disease (C), psychological stress to systemic diseases (D), and danger substances to depression (E).

#	Section	Preview
0	1. Introduction	Major depressive disorder (MDD) is characterized by depressed mood, low self-esteem, anhedonia, and…
1	1. Introduction	Although it is clear that genetic factors are involved [heritability estimates from twin studies are…
2	1. Introduction	A role for inflammation and related cytokines in MDD was first suggested in the 1980’s and since…
3	2. Comorbidity of mood disorders and systemic/peripheral diseases	Psychosocial stress and systemic disease can both affect the onset of depression. For example, the…
4	2. Comorbidity of mood disorders and systemic/peripheral diseases	Further support for this hypothesis is provided by studies demonstrating that serum levels of…
5	3. Innate immune response mechanisms	Host survival requires defense mechanisms against external danger substances, including the ability…
6	3. Innate immune response mechanisms	Induction of TNFα and IL-6 in response to TLR occurs via activation of gene transcription (Hoshino…
7	4. NLRP3 inflammasome and pattern recognition	The PRR danger signal receptors are divided into two major types membrane-associated and cytosolic,…
8	4. NLRP3 inflammasome and pattern recognition	In non-stimulated cells, the activity of NLRP3 is inhibited through binding of the LRR to the NACHT…
9	5. Inflammasome is a key mediator of stress, depression and comorbid illnesses	This review focuses on the role of the inflammasome and IL-1β in depression for several reasons.…
10	5. Inflammasome is a key mediator of stress, depression and comorbid illnesses — 5.1. Inflammatory cytokines are elevated in depression	Although the role of the NLRP3 complex in the response to psychological stressors and depression has…
11	5. Inflammasome is a key mediator of stress, depression and comorbid illnesses — 5.2. Inflammatory cytokines and dysfunction of the HPA axis	Inflammatory cytokines are potent activators of the HPA axis (Berkenbosch et al., 1987; Sapolsky et…
12	5. Inflammasome is a key mediator of stress, depression and comorbid illnesses — 5.2. Inflammatory cytokines and dysfunction of the HPA axis	Decreased glucocorticoid receptor (GR) expression and function and loss of negative feedback could…
13	5. Inflammasome is a key mediator of stress, depression and comorbid illnesses — 5.2. Inflammatory cytokines and dysfunction of the HPA axis	Sustained levels of glucocorticoids can cause atrophy of pyramidal neurons in the hippocampus and…
14	5. Inflammasome is a key mediator of stress, depression and comorbid illnesses — 5.3. NLRP3 inflammasome and comorbidity of depression	Examination of the relationship between depression and comorbid illnesses suggests a role for the…
15	5. Inflammasome is a key mediator of stress, depression and comorbid illnesses — 5.3. NLRP3 inflammasome and comorbidity of depression	The NLRP3 inflammasome is constitutively expressed in macrophages and microglia, the resident…
16	5. Inflammasome is a key mediator of stress, depression and comorbid illnesses — 5.4. Inflammatory cytokines cause depressive behaviors: possible mechanisms	The sickness behavior resulting from IL-1β exposure includes depressive symptoms such as…
17	5. Inflammasome is a key mediator of stress, depression and comorbid illnesses — 5.4. Inflammatory cytokines cause depressive behaviors: possible mechanisms	Systemic administration of TNFα also decreases social exploration and causes weight loss (Bluthe et…
18	5. Inflammasome is a key mediator of stress, depression and comorbid illnesses — 5.4. Inflammatory cytokines cause depressive behaviors: possible mechanisms	IL-1β decreases the expression of brain derived neurotrophic factor (BDNF) and adult hippocampal…
19	5. Inflammasome is a key mediator of stress, depression and comorbid illnesses — 5.5. Stress activates the inflammasome-IL-1β cascade	The hypothesis that IL-1β is a key factor in the pro-inflammatory response to psychological stress…

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In this knowledge base

Title	Year	PMID
Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.	2016	27028160

External

Title	Authors	Journal	Year	Link
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The gain-of-function variant in the NLRP3 gene predicts the effectiveness of brief psychotherapy but not the risk of major depression.	Ferreira FB et al.	—	2025	→
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A mitochondrial nexus in major depressive disorder: Integration with the psycho-immune-neuroendocrine network.	Ciubuc-Batcu MT et al.	—	2024	→
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Glitches in the brain: the dangerous relationship between radiotherapy and brain fog.	Marino N et al.	—	2024	→
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Impact of interleukin-1β single nucleotide polymorphisms and depressive symptoms in individuals with chronic viral hepatitis.	Huang HY et al.	—	2024	→
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L- lactate inhibits lipopolysaccharide-induced inflammation of microglia in the hippocampus.	Liang L et al.	—	2024	→
Neuromodulatory effects of leukotriene receptor antagonists: A comprehensive review.	Sood R et al.	—	2024	→
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NLRP3 inflammatory pathway. Can we unlock depression?	Ghaffaripour Jahromi G et al.	—	2024	→
Observations on the efficacy of edaravone dexborneol in preventing post-stroke depression and its inflammatory mechanism: a prospective, randomized, control trial.	Xu M et al.	—	2024	→
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Positive Effect of 6-Gingerol on Functional Plasticity of Microglia in a rat Model of LPS-induced Depression.	Liu C et al.	—	2024	→
Pro-inflammatory cytokines in stress-induced depression: Novel insights into mechanisms and promising therapeutic strategies.	Chang J et al.	—	2024	→
Recommendations for the Application of Sex and Gender Medicine in Preclinical, Epidemiological and Clinical Research.	Cattaneo A et al.	—	2024	→
Reduce stress and the risk of burnout by using yoga techniques. Pilot study.	Zok A et al.	—	2024	→
Sex-Related and Brain Regional Differences of URB597 Effects on Modulation of MAPK/PI3K Signaling in Chronically Stressed Rats.	Jankovic M et al.	—	2024	→
Size exclusion chromatography based proteomic and degradomic profiling of inflammasome-activated, murine bone marrow-derived dendritic cells highlights complex retention and release of cleavage products.	Vogele D et al.	—	2024	→
Targeting inflammasome complexes as a novel therapeutic strategy for mood disorders.	de Miranda AS et al.	—	2024	→
Targeting NLRP3 Inflammasome: Structure, Function, and Inhibitors.	Lou S et al.	—	2024	→
The protective effect of angiotensin II type I receptor blocker (valsartan) on behavioral impairment, NLRP3, BDNF, and oxidative stress in the brain tissue of ovariectomized female rats.	Erdem S et al.	—	2024	→
Toxoplasma gondii infection associated with inflammasome activation and neuronal injury.	Andreou D et al.	—	2024	→
Understanding immune system dysfunction and its context in mood disorders: psychoneuroimmunoendocrinology and clinical interventions.	Ortega MA et al.	—	2024	→
Yoga and Cardiovascular Diseases - A Mechanistic Review.	Murugesan P	—	2024	→
4-Methylesculetin ameliorates LPS-induced depression-like behavior through the inhibition of NLRP3 inflammasome.	Choudhary K et al.	—	2023	→
App-Based Mindfulness for Attenuation of Subjective and Physiological Stress Reactivity in a Population With Elevated Stress: Randomized Controlled Trial.	Kirk U et al.	—	2023	→
Association Between Depression Before Hematopoietic Stem Cell Transplantation and Posttransplant Survival: A Systematic Review and Meta-analysis.	Guillaume M et al.	—	2023	→
Associations of polysocial risk score with incident rosacea: a prospective cohort study of government employees in China.	Chen P et al.	—	2023	→
Baseline levels of miR-223-3p correlate with the effectiveness of electroconvulsive therapy in patients with major depression.	Kaurani L et al.	—	2023	→
Brain response in asthma: the role of "lung-brain" axis mediated by neuroimmune crosstalk.	Wang Y et al.	—	2023	→
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder.	Recourt K et al.	—	2023	→
Cross-sectional proteomic expression in Parkinson's disease-related proteins in drug-naïve patients vs healthy controls with longitudinal clinical follow-up.	Abdi IY et al.	—	2023	→
Developmental Exposure to Kynurenine Affects Zebrafish and Rat Behavior.	Marszalek-Grabska M et al.	—	2023	→
Elevated Systemic Levels of Markers Reflecting Intestinal Barrier Dysfunction and Inflammasome Activation Are Correlated in Severe Mental Illness.	Jensen SB et al.	—	2023	→
Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD).	Govindula A et al.	—	2023	→
Exploring the role of inflammation in major depressive disorder: beyond the monoamine hypothesis.	Pastis I et al.	—	2023	→
How viral infections cause neuronal dysfunction: a focus on the role of microglia and astrocytes.	Hosseini S et al.	—	2023	→
Lumateperone Normalizes Pathological Levels of Acute Inflammation through Important Pathways Known to Be Involved in Mood Regulation.	Dutheil S et al.	—	2023	→
Metabolic and immune dysfunctions in post-traumatic stress disorder: what can we learn from animal models?	Lushchak O et al.	—	2023	→
Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders.	Sanford LD et al.	—	2023	→
Neuroinflammation-induced parvalbumin interneuron and oscillation deficits might contribute to neurobehavioral abnormities in a two-hit model of depression.	Liu QR et al.	—	2023	→
On the road to resilience: Epigenetic effects of meditation.	Verdone L et al.	—	2023	→
Personality traits and the degree of work addiction among Polish women: the mediating role of depressiveness.	Rachubińska K et al.	—	2023	→
Perspectives on Agmatine Neurotransmission in Acute and Chronic Stressrelated Conditions.	Hassanshahi A et al.	—	2023	→
Possible role of the NLRP3 inflammasome and the gut-brain axis in multiple sclerosis-related depression.	Maciak K et al.	—	2023	→
Prior exposure to stress exacerbates neuroinflammation and causes long-term behavior changes in sepsis.	Miyao M et al.	—	2023	→
Quadrato motor training (QMT) influences IL-1β expression and creativity: Implications for inflammatory state reduction and cognitive enhancement.	Verdone L et al.	—	2023	→
The NLRP3 Inflammasome in Stress Response: Another Target for the Promiscuous Cannabidiol.	Hartmann A et al.	—	2023	→
The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity.	Baysak E et al.	—	2023	→
The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts.	Hou R et al.	—	2023	→
Transient anxiety-and depression-like behaviors are linked to the depletion of Foxp3-expressing cells via inflammasome in the brain.	Yang EJ et al.	—	2023	→
Acute immobilization stress evokes sexually dimorphic peripheral and hippocampal neuroimmune responses in adult rats.	Sood A et al.	—	2022	→
Allostatic load and systemic comorbidities in psychiatric disorders.	Finlay S et al.	—	2022	→
Augmented T-cell mitochondrial reactive oxygen species in adults with major depressive disorder.	Grotle AK et al.	—	2022	→
Beyond the neuron: Role of non-neuronal cells in stress disorders.	Cathomas F et al.	—	2022	→
Brain-immune interaction mechanisms: Implications for cognitive dysfunction in psychiatric disorders.	Zhao F et al.	—	2022	→
Brick by Brick: Building a Transdiagnostic Understanding of Inflammation in Psychiatry.	Thylur DS et al.	—	2022	→
Comorbidity Between Recent Diagnosis of Type 2 Diabetes and Non-Psychotic Psychiatric Disorders: Metabolic Characteristics and Clinical Correlates.	Alcántara-Garcés MT et al.	—	2022	→
Diseases prevalent before major depressive disorder diagnosis: an exploratory nested case-control study using health insurance-based claims data.	Cho Y et al.	—	2022	→
Epigenetic impact of a 1-week intensive multimodal group program for adolescents with multiple adverse childhood experiences.	Kaliman P et al.	—	2022	→
Experiencing Stress During COVID-19: A Computational Analysis of Stressors and Emotional Responses to Stress.	Kang J et al.	—	2022	→
Genome-Wide mRNA Expression Analysis of Acute Psychological Stress Responses.	Logan JG et al.	—	2022	→
Glial Cells and Brain Diseases: Inflammasomes as Relevant Pathological Entities.	Mata-Martínez E et al.	—	2022	→
<i>Achyranthes aspera</i> ameliorates stress induced depression in mice by regulating neuroinflammatory cytokines.	Gawande D et al.	—	2022	→
Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis.	Werner MCF et al.	—	2022	→
Inflammation as a Pathophysiologic Pathway to Anhedonia: Mechanisms and Therapeutic Implications.	Bekhbat M et al.	—	2022	→
Ketogenic and Modified Mediterranean Diet as a Tool to Counteract Neuroinflammation in Multiple Sclerosis: Nutritional Suggestions.	Di Majo D et al.	—	2022	→
Leukotrienes vs. Montelukast-Activity, Metabolism, and Toxicity Hints for Repurposing.	Marques CF et al.	—	2022	→
Loneliness and the Degree of Addiction to Shopping and Work among Polish Women: The Mediating Role of Depression.	Rachubińska K et al.	—	2022	→
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Maternal Stress during Pregnancy in Mice Induces Sex-Dependent Behavioral Alterations in Offspring along with Impaired Serotonin and Kynurenine Pathways of Tryptophan Metabolism.	Moura CA et al.	—	2022	→
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Multimodal Benefits of Exercise in Patients With Multiple Sclerosis and COVID-19.	Razi O et al.	—	2022	→
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Plasma proteins from several components of the immune system differentiate chronic widespread pain patients from healthy controls - an exploratory case-control study combining targeted and non-targeted protein identification.	Gerdle B et al.	—	2022	→
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Serum NLRP3 Inflammasome and BDNF: Potential Biomarkers Differentiating Reactive and Endogenous Depression.	Yang XJ et al.	—	2022	→
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The complex relationship between gut microbiota dysregulation and mood disorders: A narrative review.	Minuti A et al.	—	2022	→
The Duration of Stress Determines Sex Specificities in the Vulnerability to Depression and in the Morphologic Remodeling of Neurons and Microglia.	Gaspar R et al.	—	2022	→
The nephrotoxic potential of polystyrene microplastics at realistic environmental concentrations.	Chen YC et al.	—	2022	→
The role of damage associated molecular pattern molecules (DAMPs) and permeability of the blood-brain barrier in depression and neuroinflammation.	Serna-Rodríguez MF et al.	—	2022	→
The treatment of depression - searching for new ideas.	Stachowicz K et al.	—	2022	→
Abnormal expression of miR-135a in patients with depression and its possible involvement in the pathogenesis of the condition.	Ding Y et al.	—	2021	→
Acupuncture inhibits NLRP3 inflammasome activation in the prefrontal cortex of a chronic stress rat model of depression.	Li X et al.	—	2021	→
Antidepressant effect of electroacupuncture on modulating the expression of c-Fos/AP-1 through the JNK signaling pathway.	Li X et al.	—	2021	→
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A Review of Skin Disease in Schizophrenia.	McPhie ML et al.	—	2021	→
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Astrocytic Kir4.1 regulates NMDAR/calpain signaling axis in lipopolysaccharide-induced depression-like behaviors in mice.	Song Z et al.	—	2021	→
A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa.	Fabrazzo M et al.	—	2021	→
Can (immune and other) gene expression help us to treat depression?	Mariani N	—	2021	→
Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation.	Wang YL et al.	—	2021	→
CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice.	Bai S et al.	—	2021	→
Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1.	Yao H et al.	—	2021	→
Chronic stress promotes acute myeloid leukemia progression through HMGB1/NLRP3/IL-1β signaling pathway.	Liu N et al.	—	2021	→
Depression: Biological markers and treatment.	Nedic Erjavec G et al.	—	2021	→
Disentangling the Molecular Mechanisms of the Antidepressant Activity of Omega-3 Polyunsaturated Fatty Acid: A Comprehensive Review of the Literature.	Kalkman HO et al.	—	2021	→
Explaining socioeconomic disparities in health behaviours: A review of biopsychological pathways involving stress and inflammation.	Kraft P et al.	—	2021	→
Fecal microbiota transplantation ameliorates stress-induced depression-like behaviors associated with the inhibition of glial and NLRP3 inflammasome in rat brain.	Rao J et al.	—	2021	→
Gene expression studies in Depression development and treatment: an overview of the underlying molecular mechanisms and biological processes to identify biomarkers.	Mariani N et al.	—	2021	→
Ginsenoside Re protects against chronic restraint stress-induced cognitive deficits through regulation of NLRP3 and Nrf2 pathways in mice.	Wang H et al.	—	2021	→
Health disparities: Intracellular consequences of social determinants of health.	Emeny RT et al.	—	2021	→
How Stress Shapes Neuroimmune Function: Implications for the Neurobiology of Psychiatric Disorders.	Koo JW et al.	—	2021	→
HPA axis regulation and epigenetic programming of immune-related genes in chronically stressed and non-stressed mid-life women.	Palma-Gudiel H et al.	—	2021	→
Impact of Stress on Epilepsy: Focus on Neuroinflammation-A Mini Review.	Espinosa-Garcia C et al.	—	2021	→
Individual stress response patterns: Preliminary findings and possible implications.	Jacoby R et al.	—	2021	→
Inflammasomes as therapeutic targets in human diseases.	Li Y et al.	—	2021	→
Innate immunity receptors in depression and suicide: upregulated NOD-like receptors containing pyrin (NLRPs) and hyperactive inflammasomes in the postmortem brains of people who were depressed and died by suicide.	Pandey GN et al.	—	2021	→
Interleukin-1 Beta in Peripheral Blood Mononuclear Cell Lysates as a Longitudinal Biomarker of Response to Antidepressants: A Pilot Study.	Ferentinos P et al.	—	2021	→
Investigating the relationship between COVID-19-related and distress and ICD-11 adjustment disorder: two cross-sectional studies.	Ben-Ezra M et al.	—	2021	→
In vitro renal toxicity evaluation of copper-based metal-organic framework HKUST-1 on human embryonic kidney cells.	Chen YC et al.	—	2021	→
Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions.	Sen ZD et al.	—	2021	→
Low doses of ketamine and guanosine abrogate corticosterone-induced anxiety-related behavior, but not disturbances in the hippocampal NLRP3 inflammasome pathway.	Camargo A et al.	—	2021	→
Neurobiology of resilience in depression: immune and vascular insights from human and animal studies.	Dudek KA et al.	—	2021	→
Neuroinflammatory and behavioral susceptibility profile of mice exposed to social stress towards cocaine effects.	Ballestín R et al.	—	2021	→
Oxidative Dysregulation in Early Life Stress and Posttraumatic Stress Disorder: A Comprehensive Review.	Karanikas E et al.	—	2021	→
P2X7R antagonists in chronic stress-based depression models: a review.	von Muecke-Heim IA et al.	—	2021	→
Psychobiological mechanisms underlying the mood benefits of meditation: A narrative review.	Pascoe MC et al.	—	2021	→
Psychologically Traumatic Oxidative Stress; A Comprehensive Review of Redox Mechanisms and Related Inflammatory Implications.	Karanikas E	—	2021	→
Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation.	Zhou Y et al.	—	2021	→
Stress Diminishes BDNF-stimulated TrkB Signaling, TrkB-NMDA Receptor Linkage and Neuronal Activity in the Rat Brain.	Robinson S et al.	—	2021	→
Stress increases blood beta-hydroxybutyrate levels and prefrontal cortex NLRP3 activity jointly in a rodent model.	Nishiguchi T et al.	—	2021	→
Susceptibility of Women to Cardiovascular Disease and the Prevention Potential of Mind-Body Intervention by Changes in Neural Circuits and Cardiovascular Physiology.	Yang HJ et al.	—	2021	→
Systemic inflammation and emotional responses during the COVID-19 pandemic.	Hamilton OS et al.	—	2021	→
Telomere Shortening and Psychiatric Disorders: A Systematic Review.	Pousa PA et al.	—	2021	→
The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder.	Czarny P et al.	—	2021	→
The mechanism of electroacupuncture for depression on basic research: a systematic review.	Han X et al.	—	2021	→
The Person's Care Requires a Sex and Gender Approach.	Campesi I et al.	—	2021	→
Tumor necrosis factor α negatively regulates the retrieval and reconsolidation of hippocampus-dependent memory.	Takahashi S et al.	—	2021	→
Update on the Relationship Between Depression and Neuroendocrine Metabolism.	Qiu W et al.	—	2021	→
Variability in Behavioral Phenotypes after Forced Swimming-Induced Stress in Rats Is Associated with Expression of the Glucocorticoid Receptor, Nurr1, and IL-1β in the Hippocampus.	Ruiz-Sánchez E et al.	—	2021	→
A Combined Digital and Biomarker Diagnostic Aid for Mood Disorders (the Delta Trial): Protocol for an Observational Study.	Olmert T et al.	—	2020	→
Antidepressant-like effects of penta-acetyl geniposide in chronic unpredictable mild stress-induced depression rat model: Involvement of inhibiting neuroinflammation in prefrontal cortex and regulating hypothalamic-pituitaryadrenal axis.	Cai L et al.	—	2020	→
Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model.	Yamanashi T et al.	—	2020	→
Bibliometric Analysis of the Inflammasome and Pyroptosis in Brain.	Chen Y et al.	—	2020	→
Cell Type-Specific Methylome-wide Association Studies Implicate Neurotrophin and Innate Immune Signaling in Major Depressive Disorder.	Chan RF et al.	—	2020	→
Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial.	Recourt K et al.	—	2020	→
Clinical and biological impact of the exposome on the skin.	Passeron T et al.	—	2020	→
Correlations Between <i>SIRT</i> Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section.	Luo SC et al.	—	2020	→
Decreased Colonic Guanylin/Uroguanylin Expression and Dried Stool Property in Mice With Social Defeat Stress.	Ebisutani N et al.	—	2020	→
Deep phenotyping of attention impairments and the 'Inattention Biotype' in Major Depressive Disorder.	Keller AS et al.	—	2020	→
Depression in patients with spondyloarthritis: prevalence, incidence, risk factors, mechanisms and management.	Parkinson JT et al.	—	2020	→
Dispositional mindfulness as a moderator between perceived stress and psychological symptoms in Chinese digestive tract cancer patients.	Zhong M et al.	—	2020	→
Dopamine activates NF-κB and primes the NLRP3 inflammasome in primary human macrophages.	Nolan RA et al.	—	2020	→
Fingolimod suppressed the chronic unpredictable mild stress-induced depressive-like behaviors via affecting microglial and NLRP3 inflammasome activation.	Guo Y et al.	—	2020	→
Huoxue Jiedu Huayu Recipe Ameliorates Mesangial Cell Pyroptosis in Contralateral Kidney of UUO Rats.	Zhang Y et al.	—	2020	→
Inflammation, reward circuitry and symptoms of anhedonia and PTSD in trauma-exposed women.	Mehta ND et al.	—	2020	→
<i>trans</i>-Cinnamaldehyde Reverses Depressive-Like Behaviors in Chronic Unpredictable Mild Stress Rats by Inhibiting NF-<i>κ</i>B/NLRP3 Inflammasome Pathway.	Wang M et al.	—	2020	→
Meditation and Endocrine Health and Wellbeing.	Pascoe MC et al.	—	2020	→
NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice.	Li D et al.	—	2020	→
NLRP1-Mediated Antidepressant Effect of Ketamine in Chronic Unpredictable Mild Stress Model in Rats.	Aricioğlu F et al.	—	2020	→
Ongoing Research on the Role of Gintonin in the Management of Neurodegenerative Disorders.	Ikram M et al.	—	2020	→
Plasma protein patterns are strongly correlated with pressure pain thresholds in women with chronic widespread pain and in healthy controls-an exploratory case-control study.	Gerdle B et al.	—	2020	→
Post-approval Safety Surveillance Study of Golimumab in the Treatment of Rheumatic Disease Using a United States Healthcare Claims Database.	Ziyadeh NJ et al.	—	2020	→
Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression.	Kajitani N et al.	—	2020	→
Protective effects of morin against depressive-like behavior prompted by chronic unpredictable mild stress in rats: Possible role of inflammasome-related pathways.	Hassan MM et al.	—	2020	→
Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults.	Liu RT et al.	—	2020	→
Regulation of indoleamine 2, 3-dioxygenase in hippocampal microglia by NLRP3 inflammasome in lipopolysaccharide-induced depressive-like behaviors.	Zhang S et al.	—	2020	→
Role of Interleukin-6 in Depressive Disorder.	Ting EY et al.	—	2020	→
Scaffold hopping of agomelatine leads to enhanced antidepressant effects by modulation of gut microbiota and host immune responses.	An Q et al.	—	2020	→
State-of-the-Art: Inflammatory and Metabolic Markers in Mood Disorders.	Mucci F et al.	—	2020	→
Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways.	Welcome MO et al.	—	2020	→
Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice.	Dong Y et al.	—	2020	→
The Association of Major Depressive Disorder with Activation of NLRP3 Inflammasome, Lipid Peroxidation, and Total Antioxidant Capacity.	Taene A et al.	—	2020	→
The clinically crucial predictors of depression in women with systemic autoimmune diseases.	Hung HM et al.	—	2020	→
The mediation role of work-life balance stress and chronic fatigue in the relationship between workaholism and depression among Chinese male workers in Hong Kong.	Yang X et al.	—	2020	→
Ambient PM2.5 caused depressive-like responses through Nrf2/NLRP3 signaling pathway modulating inflammation.	Chu C et al.	—	2019	→
Antidepressant-like Effects Induced by Chronic Blockade of the Purinergic 2X7 Receptor through Inhibition of Non-like Receptor Protein 1 Inflammasome in Chronic Unpredictable Mild Stress Model of Depression in Rats.	Aricioglu F et al.	—	2019	→
Avicularin Relieves Depressive-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice.	Shen Z et al.	—	2019	→
Bipolar disorder and 1513A>C P2RX7 polymorphism frequency.	Gubert C et al.	—	2019	→
Brain education-based meditation for patients with hypertension and/or type 2 diabetes: A pilot randomized controlled trial.	Lee SH et al.	—	2019	→
Depression and obesity: evidence of shared biological mechanisms.	Milaneschi Y et al.	—	2019	→
Depressive Syndromes Associated with Alcohol Dependence.	Napryeyenko O et al.	—	2019	→
Dopaminergic impact of cART and anti-depressants on HIV neuropathogenesis in older adults.	Matt SM et al.	—	2019	→
[Exercise for depression treatment. Physiological mechanisms].	Gultyaeva VV et al.	—	2019	→
Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2.	Zhang Y et al.	—	2019	→
Hypertension linked to allostatic load: from psychosocial stress to inflammation and mitochondrial dysfunction.	Mocayar Marón FJ et al.	—	2019	→
Immune mechanisms of stress susceptibility and resilience: Lessons from animal models.	Tsyglakova M et al.	—	2019	→
Involvement of inflammatory gene expression pathways in depressed patients with hyperphagia.	de Kluiver H et al.	—	2019	→
Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors.	Cordeiro RC et al.	—	2019	→
Main and interactive effects of inflammation and perceived neighbourhood cohesion on psychological distress: results from a population-based study in the UK.	Papachristou E et al.	—	2019	→
Malaria, immunity and mental disorders: A plausible relationship?	Varo R et al.	—	2019	→
Malaria, mental disorders, immunity and their inter-relationships - A cross sectional study in a household population in a health and demographic surveillance site in Kenya.	Jenkins R et al.	—	2019	→
Minocycline Relieves Depressive-Like Behaviors in Rats With Bone Cancer Pain by Inhibiting Microglia Activation in Hippocampus.	Dai J et al.	—	2019	→
Molecular aspects of depression: A review from neurobiology to treatment.	Villas Boas GR et al.	—	2019	→
Neurobiology of Resilience: Interface Between Mind and Body.	Cathomas F et al.	—	2019	→
Neuroendocrine Regulation of Brain Cytokines After Psychological Stress.	Johnson JD et al.	—	2019	→
NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway.	Wang W et al.	—	2019	→
Paricalcitol alleviates lipopolysaccharide-induced depressive-like behavior by suppressing hypothalamic microglia activation and neuroinflammation.	He MC et al.	—	2019	→
Paying attention to attention in depression.	Keller AS et al.	—	2019	→
Plasma microRNA expression levels and their targeted pathways in patients with major depressive disorder who are responsive to duloxetine treatment.	Kim HK et al.	—	2019	→
Predictable chronic mild stress promotes recovery from LPS-induced depression.	Dang R et al.	—	2019	→
Probiotics modify body weight together with anxiety states via pro-inflammatory factors in HFD-treated Syrian golden hamster.	Avolio E et al.	—	2019	→
Role of Chronic Administration of Antidepressant Drugs in the Prenatal Stress-Evoked Inflammatory Response in the Brain of Adult Offspring Rats: Involvement of the NLRP3 Inflammasome-Related Pathway.	Trojan E et al.	—	2019	→
Role of Inflammation in Depression and Treatment Implications.	Felger JC	—	2019	→
Roles of Inflammasomes in Inflammatory Kidney Diseases.	Fan J et al.	—	2019	→
Salvianolic acid B abolished chronic mild stress-induced depression through suppressing oxidative stress and neuro-inflammation via regulating NLRP3 inflammasome activation.	Huang Q et al.	—	2019	→
Sedentary behaviour and chronic stress in old age: A cross-sectional analysis of TV viewing and hair cortisol concentrations.	Jackson SE et al.	—	2019	→
Silymarin and silymarin nanoparticles guard against chronic unpredictable mild stress induced depressive-like behavior in mice: involvement of neurogenesis and NLRP3 inflammasome.	Ashraf A et al.	—	2019	→
The level of IL-6 was associated with sleep disturbances in patients with major depressive disorder.	Wang M et al.	—	2019	→
A Logic Model of Neuronal-Glial Interaction Suggests Altered Homeostatic Regulation in the Perpetuation of Neuroinflammation.	Craddock TJA et al.	—	2018	→
Anti-cytokine agents for anhedonia: targeting inflammation and the immune system to treat dimensional disturbances in depression.	Lee Y et al.	—	2018	→
Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats.	Park HJ et al.	—	2018	→
Brain inflammasomes in stroke and depressive disorders: Regulation by oestrogen.	Slowik A et al.	—	2018	→
Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression.	Zou W et al.	—	2018	→
Cotinine Plus Krill Oil Decreased Depressive Behavior, and Increased Astrocytes Survival in the Hippocampus of Mice Subjected to Restraint Stress.	Mendoza C et al.	—	2018	→
Could listening to music during pregnancy be protective against postnatal depression and poor wellbeing post birth? Longitudinal associations from a preliminary prospective cohort study.	Fancourt D et al.	—	2018	→
Crocin, a natural product attenuates lipopolysaccharide-induced anxiety and depressive-like behaviors through suppressing NF-kB and NLRP3 signaling pathway.	Zhang L et al.	—	2018	→
Cytoprotective effects of xanthohumol against methylglyoxal-induced cytotoxicity in MC3T3-E1 osteoblastic cells.	Suh KS et al.	—	2018	→
Depression and Obesity: Integrating the Role of Stress, Neuroendocrine Dysfunction and Inflammatory Pathways.	Ouakinin SRS et al.	—	2018	→
Depression as a risk factor for the development of rheumatoid arthritis: a population-based cohort study.	Vallerand IA et al.	—	2018	→
Dynamic Effects of Early Adolescent Stress on Depressive-Like Behaviors and Expression of Cytokines and JMJD3 in the Prefrontal Cortex and Hippocampus of Rats.	Wang R et al.	—	2018	→
Electro-Acupuncture Alleviates Chronic Unpredictable Stress-Induced Depressive- and Anxiety-Like Behavior and Hippocampal Neuroinflammation in Rat Model of Depression.	Yue N et al.	—	2018	→
Imaging the Role of Inflammation in Mood and Anxiety-related Disorders.	Felger JC	—	2018	→
Inflammation and depression: a causal or coincidental link to the pathophysiology?	Leonard BE	—	2018	→
Inflammatory Mediators in Mood Disorders: Therapeutic Opportunities.	Pfau ML et al.	—	2018	→
Mechanisms of vagal plasticity influencing feeding behavior.	de Lartigue G et al.	—	2018	→
Microglia and CNS Interleukin-1: Beyond Immunological Concepts.	Liu X et al.	—	2018	→
Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats.	Wang YL et al.	—	2018	→
Microglia Polarization and Endoplasmic Reticulum Stress in Chronic Social Defeat Stress Induced Depression Mouse.	Tang J et al.	—	2018	→
Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis.	Morris G et al.	—	2018	→
Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia.	Bhattacharya A et al.	—	2018	→
Persistent Increase in Microglial RAGE Contributes to Chronic Stress-Induced Priming of Depressive-like Behavior.	Franklin TC et al.	—	2018	→
Repeated daily administration of increasing doses of lipopolysaccharide provides a model of sustained inflammation-induced depressive-like behaviour in mice that is independent of the NLRP3 inflammasome.	Wickens RA et al.	—	2018	→
Resilience Dysregulation in Major Depressive Disorder: Focus on Glutamatergic Imbalance and Microglial Activation.	Reus GZ et al.	—	2018	→
Sex differences in the neuro-immune consequences of stress: Focus on depression and anxiety.	Bekhbat M et al.	—	2018	→
Single-nucleotide polymorphisms of uracil-processing genes affect the occurrence and the onset of recurrent depressive disorder.	Czarny P et al.	—	2018	→
The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression.	Czarny P et al.	—	2018	→
The Microbiota-Inflammasome Hypothesis of Major Depression.	Inserra A et al.	—	2018	→
The molecular aspects of oxidative & nitrosative stress and the tryptophan catabolites pathway (TRYCATs) as potential causes of depression.	Wigner P et al.	—	2018	→
Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer.	Barreto FS et al.	—	2018	→
Urban Greenspace is Associated with Reduced Psychological Stress among Adolescents: A Geographic Ecological Momentary Assessment (GEMA) Analysis of Activity Space.	Mennis J et al.	—	2018	→
Weathering the storm; a review of pre-pregnancy stress and risk of spontaneous abortion.	Frazier T et al.	—	2018	→
4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.	Letavic MA et al.	—	2017	→
Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus.	Zhao XJ et al.	—	2017	→
Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors.	Yue N et al.	—	2017	→
A multispecies approach for understanding neuroimmune mechanisms of stress.	Deak T et al.	—	2017	→
Antidepressant-like effect of a new selenium-containing compound is accompanied by a reduction of neuroinflammation and oxidative stress in lipopolysaccharide-challenged mice.	Casaril AM et al.	—	2017	→
Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder.	Alcocer-Gómez E et al.	—	2017	→
Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance.	Su WJ et al.	—	2017	→
Baicalin ameliorates chronic unpredictable mild stress-induced depressive behavior: Involving the inhibition of NLRP3 inflammasome activation in rat prefrontal cortex.	Liu X et al.	—	2017	→
Banxia-houpu decoction restores glucose intolerance in CUMS rats through improvement of insulin signaling and suppression of NLRP3 inflammasome activation in liver and brain.	Jia KK et al.	—	2017	→
Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses.	Yamanashi T et al.	—	2017	→
Chronic social isolation in adaptation of HPA axis to heterotypic stress.	Gądek-Michalska A et al.	—	2017	→
Depression Is Associated with an Increased Risk of Psoriatic Arthritis among Patients with Psoriasis: A Population-Based Study.	Lewinson RT et al.	—	2017	→
Depressive-like behavior, its sensitization, social buffering, and altered cytokine responses in rhesus macaques moved from outdoor social groups to indoor housing.	Hennessy MB et al.	—	2017	→
Divergence in Morris Water Maze-Based Cognitive Performance under Chronic Stress Is Associated with the Hippocampal Whole Transcriptomic Modification in Mice.	Jung SH et al.	—	2017	→
Early-life lipopolysaccharide exposure potentiates forebrain expression of NLRP3 inflammasome proteins and anxiety-like behavior in adolescent rats.	Lei Y et al.	—	2017	→
Family Member Deaths in Childhood Predict Systemic Inflammation in Late Life.	Norton MC et al.	—	2017	→
Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells.	Ohgidani M et al.	—	2017	→
Genetic Contributions of Inflammation to Depression.	Barnes J et al.	—	2017	→
Genome-wide transcriptome analysis of hippocampus in rats indicated that TLR/NLR signaling pathway was involved in the pathogenisis of depressive disorder induced by chronic restraint stress.	Wang Y et al.	—	2017	→
Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience.	Ménard C et al.	—	2017	→
Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders.	Haroon E et al.	—	2017	→
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond.	Michopoulos V et al.	—	2017	→
Inflammatory pathway genes associated with inter-individual variability in the trajectories of morning and evening fatigue in patients receiving chemotherapy.	Wright F et al.	—	2017	→
Inhibition of NLRP3 inflammasome: a new protective mechanism of cinnamaldehyde in endotoxin poisoning of mice.	Xu F et al.	—	2017	→
Integrative concepts of rosacea pathophysiology, clinical presentation and new therapeutics.	Holmes AD et al.	—	2017	→
Investigating mental health in patients with osteoarthritis and its relationship with some clinical and demographic factors.	Nazarinasab M et al.	—	2017	→
Ionizing Radiation-Induced Immune and Inflammatory Reactions in the Brain.	Lumniczky K et al.	—	2017	→
Mangiferin inhibits hippocampal NLRP3 inflammasome and exerts antidepressant effects in a chronic mild stress mice model.	Cao C et al.	—	2017	→
Melatonin protects mice against stress-induced inflammation through enhancement of M2 macrophage polarization.	Yi WJ et al.	—	2017	→
Microglia: An Interface between the Loss of Neuroplasticity and Depression.	Singhal G et al.	—	2017	→
Mindfulness mediates the physiological markers of stress: Systematic review and meta-analysis.	Pascoe MC et al.	—	2017	→
Molecular and Epigenetic Mechanisms for the Complex Effects of Stress on Synaptic Physiology and Cognitive Functions.	Yuen EY et al.	—	2017	→
NLRP3 gene knockout blocks NF-κB and MAPK signaling pathway in CUMS-induced depression mouse model.	Su WJ et al.	—	2017	→
NLRP3 inflammasome: common nexus between depression and cardiovascular diseases.	Alcocer-Gómez E et al.	—	2017	→
NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings.	Kaufmann FN et al.	—	2017	→
Novel rapid-acting antidepressants: molecular and cellular signaling mechanisms.	Thomas AM et al.	—	2017	→
Senegenin exerts anti-depression effect in mice induced by chronic un-predictable mild stress via inhibition of NF-κB regulating NLRP3 signal pathway.	Li H et al.	—	2017	→
Subjective Memory Change, Mood, and Cerebrovascular Risk Factors in Older African Americans.	Sperling SA et al.	—	2017	→
The Neurobiology of Depression: an Integrated Overview from Biological Theories to Clinical Evidence.	Ferrari F et al.	—	2017	→
The role of anxious distress in immune dysregulation in patients with major depressive disorder.	Gaspersz R et al.	—	2017	→
Yoga, mindfulness-based stress reduction and stress-related physiological measures: A meta-analysis.	Pascoe MC et al.	—	2017	→
Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior.	Crews FT et al.	—	2016	→
Agmatine Reverses Sub-chronic Stress induced Nod-like Receptor Protein 3 (NLRP3) Activation and Cytokine Response in Rats.	Sahin C et al.	—	2016	→
Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain.	Li R et al.	—	2016	→
A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood.	Sakharkar AJ et al.	—	2016	→
ASC provides a potential link between depression and inflammatory disorders: A clinical study of depressed Iranian medical students.	Momeni M et al.	—	2016	→
Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness.	Duric V et al.	—	2016	→
Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression.	Haroon E et al.	—	2016	→
Cross-species evidence for the role of interleukin-33 in depression risk.	Kudinova AY et al.	—	2016	→
Desipramine administered chronically inhibits lipopolysaccharide-stimulated production of IL-1β in the brain and plasma of rats.	Obuchowicz E et al.	—	2016	→
Effects of hydrogen-rich water on depressive-like behavior in mice.	Zhang Y et al.	—	2016	→
Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms.	Kankaanranta H et al.	—	2016	→
Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.	Sherva R et al.	—	2016	→
High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation.	Dutheil S et al.	—	2016	→
Inflammasome Activation in Major Depressive Disorder: A Pivotal Linkage Between Psychological Stress, Purinergic Signaling, and the Kynurenine Pathway.	Velasquez S et al.	—	2016	→
Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition.	Wong ML et al.	—	2016	→
Integrating neuroimmune systems in the neurobiology of depression.	Wohleb ES et al.	—	2016	→
Learned helplessness activates hippocampal microglia in rats: A potential target for the antidepressant imipramine.	Iwata M et al.	—	2016	→
Molecular serum signature of treatment resistant depression.	Ruland T et al.	—	2016	→
Neuroinflammation: the devil is in the details.	DiSabato DJ et al.	—	2016	→
P2X ion channel receptors and inflammation.	Burnstock G	—	2016	→
Persistent adaptation by chronic alcohol is facilitated by neuroimmune activation linked to stress and CRF.	Breese GR et al.	—	2016	→
Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor.	Iwata M et al.	—	2016	→
Psychosocial stress inhibits additional stress-induced hyperexpression of NO synthases and IL-1β in brain structures.	Gądek-Michalska A et al.	—	2016	→
Purinergic mechanisms in neuroinflammation: An update from molecules to behavior.	Beamer E et al.	—	2016	→
Stress and Withdrawal from Chronic Ethanol Induce Selective Changes in Neuroimmune mRNAs in Differing Brain Sites.	Knapp DJ et al.	—	2016	→
Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome.	Alcocer-Gómez E et al.	—	2016	→
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants.	Duman RS et al.	—	2016	→
The Immune System and the Role of Inflammation in Perinatal Depression.	Leff-Gelman P et al.	—	2016	→
The role of IL18-607C>A and IL18-137G>C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report.	Santos M et al.	—	2016	→
The role of inflammation in depression: from evolutionary imperative to modern treatment target.	Miller AH et al.	—	2016	→
TNF-α from hippocampal microglia induces working memory deficits by acute stress in mice.	Ohgidani M et al.	—	2016	→
Transcriptomic Modification in the Cerebral Cortex following Noninvasive Brain Stimulation: RNA-Sequencing Approach.	Holmes B et al.	—	2016	→
A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334.	Lord B et al.	—	2015	→
A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior.	Vollmer LL et al.	—	2015	→
Cardiovascular Update: Risk, Guidelines, and Recommendations.	Pearson T	—	2015	→
Chemobrain: a critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy.	Wang XM et al.	—	2015	→
Depression and posttraumatic stress disorder among women with vulvodynia: evidence from the population-based woman to woman health study.	Iglesias-Rios L et al.	—	2015	→
Elevated level of DNA damage and impaired repair of oxidative DNA damage in patients with recurrent depressive disorder.	Czarny P et al.	—	2015	→
Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases.	Pedersen BK et al.	—	2015	→
Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation.	Liu B et al.	—	2015	→
IL-6, IL-18, sIL-2R, and TNFα proinflammatory markers in depression and schizophrenia patients who are free of overt inflammation.	Al-Hakeim HK et al.	—	2015	→
Inflammatory cytokine-associated depression.	Lotrich FE	—	2015	→
L-Menthone confers antidepressant-like effects in an unpredictable chronic mild stress mouse model via NLRP3 inflammasome-mediated inflammatory cytokines and central neurotransmitters.	Xue J et al.	—	2015	→
Neurocognitive function, brain-derived neurotrophic factor (BDNF) and IL-6 levels in cancer patients with depression.	Jehn CF et al.	—	2015	→
NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation.	Zhang Y et al.	—	2015	→
Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists.	Rudolph DA et al.	—	2015	→
Peripheral and Central Mechanisms of Stress Resilience.	Pfau ML et al.	—	2015	→
Phenotypes, Risk Factors, and Mechanisms of Adult-Onset Asthma.	Ilmarinen P et al.	—	2015	→
Relationship between hypothalamic-pituitary-adrenal axis dysregulation and insulin resistance in elderly patients with depression.	Yokoyama K et al.	—	2015	→
Risk and Resilience: Animal Models Shed Light on the Pivotal Role of Inflammation in Individual Differences in Stress-Induced Depression.	Felger JC et al.	—	2015	→
Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain.	Sawicki CM et al.	—	2015	→
Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.	Stehouwer JS et al.	—	2015	→
Temporal associations between the different domains of rheumatoid arthritis disease activity and the onset of patient-reported depressive symptoms.	Rathbun AM et al.	—	2015	→
Temporal effect of depressive symptoms on the longitudinal evolution of rheumatoid arthritis disease activity.	Rathbun AM et al.	—	2015	→
Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice.	Deng XY et al.	—	2015	→
Treat the brain and treat the periphery: toward a holistic approach to major depressive disorder.	Zheng X et al.	—	2015	→
Association between mental disorders and subsequent adult onset asthma.	Alonso J et al.	—	2014	→
Can the blues make it harder to breathe?	Carroll KN	—	2014	→
Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction.	Jacobsen JH et al.	—	2014	→
Fresh approaches to antidepressant drug discovery.	Anacker C	—	2014	→
Inflammasomes in neuroinflammation and changes in brain function: a focused review.	Singhal G et al.	—	2014	→
Inflammasomes: molecular regulation and implications for metabolic and cognitive diseases.	Choi AJ et al.	—	2014	→
Involvement of inflammasome activation in lipopolysaccharide-induced mice depressive-like behaviors.	Zhang Y et al.	—	2014	→
Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats.	Pan Y et al.	—	2014	→
NLRP3 inflammasome: a new target in major depressive disorder.	Alcocer-Gómez E et al.	—	2014	→
NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder.	Alcocer-Gómez E et al.	—	2014	→
P2X7 antagonists as potential therapeutic agents for the treatment of CNS disorders.	Chrovian CC et al.	—	2014	→
P2X7 receptor: an emerging target in central nervous system diseases.	Sperlágh B et al.	—	2014	→
Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections.	Duman RS	—	2014	→
Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432.	Lord B et al.	—	2014	→
Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain.	Wohleb ES et al.	—	2014	→
Role of immune-inflammatory and oxidative and nitrosative stress pathways in the etiology of depression: therapeutic implications.	Anderson G et al.	—	2014	→
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications.	Felger JC et al.	—	2013	→
Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice.	Lawson MA et al.	—	2013	→
Malaise, melancholia and madness: the evolutionary legacy of an inflammatory bias.	Raison CL et al.	—	2013	→
Neurobiological advances identify novel antidepressant targets.	Duman RS	—	2013	→
Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.	Bhattacharya A et al.	—	2013	→
Quam bene vivas referre: curing and caring in psycho-oncology.	Grassi L	—	2013	→
Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists.	Letavic MA et al.	—	2013	→
Towards translational rodent models of depression.	O'Leary OF et al.	—	2013	→