Using LDSC, we assessed the rg of PTSD derived from the PGC meta-analysis conducted in EUR cohorts with traits available from the Pan-UKB analysis conducted in EUR samples. Details regarding the Pan-UKB analysis are available at https://pan.ukbb.broadinstitute.org/. Briefly, Pan-UKB genome-wide association statistics were generated using the SAIGE and including a kinship matrix as a random effect and covariates as fixed effects. The covariates included age, sex, age × sex, age2, age2 × sex, and the top-10 within-ancestry principal components. We limited our analysis to data derived from UKB participants of European descent (n = 420,531) because of the limited sample size available in the other ancestry groups. Initially, we calculated SNP-based heritability of phenotypes available from Pan-UKB, retaining only those with SNP-based heritability z > 6 (Supplementary Table 25) as recommended by the developers of LDSC117. To define traits genetically correlated with PTSD, we applied a Bonferroni correction accounting for the number of tests performed.
