We initially limited drug target analyses to drugs with two or more targets. However, results suggested this low limit may lead to false positive findings. As a sensitivity analysis, we further limited these analyses to drugs with 10 or more targets. Multiple testing was controlled using a Bonferroni-corrected significance threshold of P < 5.42 × 10−5 for drug target analysis and P < 7.94 × 10−4 for drug class analysis, accounting for 923 drug sets and 63 drug classes tested.
