We grouped drugs according to the Anatomical Therapeutic Chemical class of the drug111. Results from the drug target analysis were ranked, and the enrichment of each class in the drug target analysis was assessed with enrichment curves. We calculated the area under the enrichment curve and compared the ranks of drugs within the class to those outside the class using the Wilcoxon Mann-Whitney test. Multiple testing was controlled using a Bonferroni-corrected significance threshold of P < 3.27 × 10−5 for drug target analysis and P < 4.42 × 10−4 for drug class analysis, accounting for 1,530 drug sets and 113 drug classes tested.
