As more GWAS summary statistics become available in the years ahead, and better methods for constructing PGIs are developed, we plan to update the Repository regularly with more predictive PGIs that leverage these advances. For example, future releases will incorporate PGIs of novel phenotypes for which it is not currently feasible to construct PGIs with meaningful predictive power. We emphasize, however, that although PGIs have attained levels of predictive power that can be useful to researchers, the limited heritability of behavioural phenotypes such as those in the Repository implies that the PGIs will never be able to predict any individual’s phenotype with much precision. Additionally, since GWAS summary statistics have only been available in large samples of individuals from European ancestries, currently available PGIs have limited portability to individuals of non-European ancestries40. In future releases of the Repository, once sufficient data becomes available to create PGIs that have non-negligible predictive power for other ancestry groups, we will update the Repository to contain such PGIs.
