Because genetic associations are easily misinterpreted, researchers who use PGIs should be especially careful to understand and convey the appropriate interpretation of their findings. For example, it is important to keep in mind that PGI associations may be mediated by environmental factors, and these factors may be modifiable. To facilitate understanding of these and other interpretational issues, we have written a User Guide that cohorts will distribute to users of the Repository PGIs (see Supplementary Methods).
