Allele frequency and pair-wise LD between the 12 CNR1 tSNPs are summarized in Table 1. Several of the tSNPs had comparatively lower allele frequencies than other tSNPs. Such differences led to inflated D′ estimates of LD with corresponding low r2 LD values (e.g. rs12720071 and rs1049353: D′=1.00 versus r2=.03). Therefore, r2 yielded a better measure of LD in our study sample. There were high inter-correlations between 2 pairs of tSNPs: rs806375/rs806376 (r2=.80) and rs6454672/rs9450898 (r2=.77). To reduce redundancy, rs806375 and rs6454672 were excluded from subsequent analyses. Genotype distributions in all 12 tSNPs were in Hardy-Weinberg equilibrium (p≥.06).
