Neurocognition-CNR1 relationships focused on SNPs where there were significant genotype-by-marijuana misuse interaction effects on brain volumes (p≤.05). In these ANCOVAs, the dependent measure was cognitive domain score (Verbal Memory, Processing Speed/Attention, Problem Solving, Language, Visuospatial Abilities or Motor Skills) with covariates being WAIS-R Full Scale IQ, gender, age and alcohol/non-cannabis illicit substance abuse/dependence.