Evidence for association with obesity was found for the SNPs in the putative regulatory region of GIPR. In nuclear families, we observed an increased transmission rate for the minor alleles of rs8111428 (G-allele) and rs2302382 (A-allele) to the obese offspring, indicating the presence of a possible risk haplotype for obesity. Further analyses in two independent samples of cases and one control sample underlined and validated this association. In two large population-based cross-sectional samples of adults, however, the results were ambiguous. While we observed a similar trend for rs2302382 in KORA (> 8,000 individuals) where the risk allele was related to an increased BMI, the same risk allele was inversely associated with BMI in SHIP.
