We provide evidence for an association of polymorphisms in and near the GIPR gene with obesity or increased BMI. We performed family-based association tests in up to 761 German nuclear families with severely obese offspring. The haplotype analyses in the genotyped region indicated the presence of two distinct regions of increased linkage disequilibrium (LD): first, a putative regulatory region for GIPR comprising SNPs rs8111428 and rs2302382 and second, a region covering the GIPR coding region comprised SNP rs1800437.
