The non-synonymous SNP Glu354Gln (rs1800437) is located in a transmembrane domain of GIPR [21]. Analysis of the SNP rs1800437 using FastSNP showed that the predicted altered protein has a low to medium risk to be damaging (ranking 2–3; whereby 5 is the maximum risk). This tool predicts that the respective mutation G/C creates an additional exonic splicing enhancer in the sequence comprising the C-allele.
