Wip1 expression is induced by a variety of exogenous stresses and subsequently regulates stress signaling through its phosphatase activity. To date, the activity of Wip1 has not been shown to be regulated through post-translational modification; the major known modulation of Wip1 phosphatase activity is through the level of its expression. The following section will review the regulation of Wip1 expression, including transcriptional and post-transcriptional mechanisms.
