the original cohort. The combined p value for the strongest associated SNP (rs2135551) across the original and first replication studies is 1.3×10−7. If we use a Bonferroni correction for all the SNPs considered in this study (312,565 SNPs that passed quality control and the minor allele restriction), the 0.05 experiment-wide cut-off is 0.05/312565 = 1.6×10−7, which means that this association is suggestive, but falls short of the proposed threshold for genome-wide significance of <5×10−8 [28].
