Chunk #19 — Results — Deleting Zfhx1b in SVZ of the MGE Using DlxI12b-Cre Phenocopies Loss of Zfhx1b function in the VZ (Nkx2.1-Cre) — Postnatal Analysis of cortical and striatal interneuron phenotypes in Nkx2.1-Cre;Zfhx1b mutants
Nkx2.1-Cre conditional mutants died between P17 and P21; at P15, mutants weighed ~30% less than their control littermates, a phenotype that was exacerbated by litter size. We did not observe seizures or other neurological/behavioral phenotypes.
