In this study, we have demonstrated that the PRS constructed from currently published GWAS results has significant, albeit insufficient for clinical use, discrimination and stratification ability for predicting PTSD diagnosis, as well as symptom severity. Theoretical analysis indicates the remaining potential of the PRS that is yet to be realized. Furthermore, the prediction ability of schizophrenia–PRS on PTSD outcomes points to the existence of polygenic overlap between PTSD and schizophrenia, confirming previously reported genetic correlation between the two disorders.
