Rate selection and subjective response assessments were repeated in 3 min epochs (Figure 1). Three min was determined to be the minimum interval over which the participant could experience the effects of the selected rate of BrAC based upon pharmacokinetic modelling of brain alcohol concentration and consistent with work by Gomez et al. 8 A visual display allowed the participant to choose the next rate of BrAC change by turning a dial. Participants were instructed that the experimental objective was to determine how much they enjoyed various alcohol exposure rates and that they would be able to increase, decrease, or keep their BrAC the same as they desired. They were encouraged to make decisions with minimal delay, during which their BrAC was held constant. The maximum ascending rate in each epoch was 5 mg/dl per min or whatever lesser rate would achieve a BrAC within 5 mg/dl of the safety limit. The maximum available descent rate was initially −5 mg/dl per min, reducing with equilibration of alcohol in the total body water, 46 , 47 , 48 , 49 and
