crucial in enhancing genetic discovery across phenotypes, they do not detect all the genetic variation relevant to individual disorders. Since ASB is a critical issue for psychiatry and for society, the present study uniquely focuses on (severe) forms of ASB and persistence over the lifespan. To do so, we initiated the Broad Antisocial Behavior Consortium (BroadABC) to perform large-scale meta-analytical genetic analyses utilizing a broad range of phenotypic ASB measures (e.g., conduct disorder symptoms, aggressive behavior, and delinquency). In our first meta-analysis [16], we demonstrated that effect sizes for SNPs with suggestive evidence of association with ASB were small, as anticipated for most polygenic traits. Still, we found that the collective effect across all of the included variants (typically referred to as “SNP heritability”) explained roughly 5% of the total variation in ASB [16], which is in line with meta-analyses of the ACTION [17] and EAGLE [18] consortium.
