Chunk #24 — Results — eQTSs identify potential driver genes for polygenic traits

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Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.

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We identified 18,210 eQTSs (FDR<0.05) representing 689 unique traits (55% of tested traits) and 2,568 genes (13% of tested genes; Supplementary Data 5, Figure 1d). Of these genes, 719 (28%) were not identified in the trans-eQTL analysis, emphasizing the value of analyzing eQTS in addition to trans-eQTLs (Figure 6a–b). Median eQTS effect sizes were smaller than for cis-eQTLs and similar to trans-eQTLs (median r=0.037; Supplementary Figure 8a, e, i).