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Chunk #25 — Results — eQTSs identify potential driver genes for polygenic traits

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Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.
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Ten eQTSs replicated in LCLs (Benjamini-Hochberg FDR<0.05), and 9 also had the same effect direction as in the discovery dataset (Supplementary Figure 12a, Supplementary Data 5), while 78 replicated in the induced pluripotent stem cells (iPSCs; Benjamini-Hochberg FDR<0.05) with 71 (91%) showing the same direction (Supplementary Figure 12b, Supplementary Data 5). We also identified 19 replicating eQTSs (Benjamini-Hochberg FDR<0.05, same effect direction) in the European subset of GTEx samples (Supplementary Note, Supplementary Data 6) and observed an inflation of replication signal in some tissues, primarily in blood (Supplementary Figure 6b).