Recent GWAS have demonstrated that 15q25.1 variation influences lung cancer risk [Amos et al., 2008; Hung et al., 2008; Thorgeirsson et al., 2008]. For example, Amos et al. [2008] conducted a multistage GWAS, where they analyzed 315,450 tagging SNPs in 1,154 current and former (ever) smoking cases of European ancestry and 1,137 frequency-matched, ever-smoking controls from Houston in the discovery phase. They evaluated the ten most highly significant SNPs in an additional 2,724 cases and 3,694 controls (711 cases and 632 controls from Texas and 2,013 cases and 3,062 controls from the UK) [Amos et al., 2008]. In applying our selection-adjusted procedure we defined the correction cutoff as the largest p-value among those for the ten selected SNPs, 4.5 × 10−5. As shown in table 2, all corrected ORs imply a weaker effect than do the uncorrected ORs. None of the bias-adjusted ORs have a statistically significant difference from the replication OR estimates. Of the 10 SNPs, 8 bias-adjusted ORs are closer to the replication estimates, the exceptions being rs8034191 and rs1051730, which showed very extreme p-values in the replication
